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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAM (ADM)
Full Name:
Peptidyl-glycine alpha-amidating monooxygenase
Alias:
ADM; PAL; PAL; PAM; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
Type:
Enzyme
Mass (Da):
108332
Number AA:
973
UniProt ID:
P19021
International Prot ID:
IPI00177543
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0016021
GO:0030141
Uniprot
OncoNet
Molecular Function:
GO:0031418
GO:0005507
GO:0004598
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006518
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
L
A
F
R
S
P
L
S
V
F
K
R
F
K
E
Site 2
T34
V
F
K
R
F
K
E
T
T
R
P
F
S
N
E
Site 3
T35
F
K
R
F
K
E
T
T
R
P
F
S
N
E
C
Site 4
S39
K
E
T
T
R
P
F
S
N
E
C
L
G
T
T
Site 5
T67
D
I
R
M
P
G
V
T
P
K
Q
S
D
T
Y
Site 6
S71
P
G
V
T
P
K
Q
S
D
T
Y
F
C
M
S
Site 7
Y74
T
P
K
Q
S
D
T
Y
F
C
M
S
M
R
I
Site 8
T100
K
P
R
A
S
M
D
T
V
H
H
M
L
L
F
Site 9
Y118
M
P
S
S
T
G
S
Y
W
F
C
D
E
G
T
Site 10
T143
W
A
R
N
A
P
P
T
R
L
P
K
G
V
G
Site 11
S159
R
V
G
G
E
T
G
S
K
Y
F
V
L
Q
V
Site 12
Y161
G
G
E
T
G
S
K
Y
F
V
L
Q
V
H
Y
Site 13
S182
R
D
N
N
K
D
C
S
G
V
S
L
H
L
T
Site 14
S185
N
K
D
C
S
G
V
S
L
H
L
T
R
L
P
Site 15
S218
A
G
E
K
V
V
N
S
D
I
S
C
H
Y
K
Site 16
S246
H
H
L
G
K
V
V
S
G
Y
R
V
R
N
G
Site 17
Y248
L
G
K
V
V
S
G
Y
R
V
R
N
G
Q
W
Site 18
T256
R
V
R
N
G
Q
W
T
L
I
G
R
Q
S
P
Site 19
S262
W
T
L
I
G
R
Q
S
P
Q
L
P
Q
A
F
Site 20
Y270
P
Q
L
P
Q
A
F
Y
P
V
G
H
P
V
D
Site 21
Y313
S
D
E
M
C
N
L
Y
I
M
Y
Y
M
E
A
Site 22
Y367
E
H
H
K
E
T
E
Y
K
D
K
I
P
L
L
Site 23
Y410
D
V
V
H
V
H
K
Y
N
P
T
E
K
A
E
Site 24
S438
Q
K
K
D
L
G
R
S
D
A
R
E
G
A
E
Site 25
S466
H
K
F
H
R
L
V
S
T
L
R
P
P
E
S
Site 26
T467
K
F
H
R
L
V
S
T
L
R
P
P
E
S
R
Site 27
S473
S
T
L
R
P
P
E
S
R
V
F
S
L
Q
Q
Site 28
S477
P
P
E
S
R
V
F
S
L
Q
Q
P
P
P
G
Site 29
T487
Q
P
P
P
G
E
G
T
W
E
P
E
H
T
G
Site 30
T493
G
T
W
E
P
E
H
T
G
D
F
H
M
E
E
Site 31
Y546
S
F
D
S
K
F
V
Y
Q
Q
I
G
L
G
P
Site 32
Y579
S
S
G
K
N
L
F
Y
L
P
H
G
L
S
I
Site 33
S585
F
Y
L
P
H
G
L
S
I
D
K
D
G
N
Y
Site 34
Y592
S
I
D
K
D
G
N
Y
W
V
T
D
V
A
L
Site 35
S620
P
V
L
I
L
G
R
S
M
Q
P
G
S
D
Q
Site 36
Y646
D
P
G
T
G
A
I
Y
V
S
D
G
Y
C
N
Site 37
S648
G
T
G
A
I
Y
V
S
D
G
Y
C
N
S
R
Site 38
Y651
A
I
Y
V
S
D
G
Y
C
N
S
R
I
V
Q
Site 39
S654
V
S
D
G
Y
C
N
S
R
I
V
Q
F
S
P
Site 40
S660
N
S
R
I
V
Q
F
S
P
S
G
K
F
I
T
Site 41
S662
R
I
V
Q
F
S
P
S
G
K
F
I
T
Q
W
Site 42
T667
S
P
S
G
K
F
I
T
Q
W
G
E
E
S
S
Site 43
S673
I
T
Q
W
G
E
E
S
S
G
S
S
P
L
P
Site 44
S674
T
Q
W
G
E
E
S
S
G
S
S
P
L
P
G
Site 45
S676
W
G
E
E
S
S
G
S
S
P
L
P
G
Q
F
Site 46
S677
G
E
E
S
S
G
S
S
P
L
P
G
Q
F
T
Site 47
T713
G
R
I
Q
C
F
K
T
D
T
K
E
F
V
R
Site 48
S725
F
V
R
E
I
K
H
S
S
F
G
R
N
V
F
Site 49
S726
V
R
E
I
K
H
S
S
F
G
R
N
V
F
A
Site 50
T802
I
G
D
A
H
T
N
T
V
W
K
F
T
L
T
Site 51
T836
E
A
E
A
V
V
E
T
K
M
E
N
K
P
T
Site 52
T843
T
K
M
E
N
K
P
T
S
S
E
L
Q
K
M
Site 53
S892
I
F
I
R
W
K
K
S
R
A
F
G
D
S
E
Site 54
S898
K
S
R
A
F
G
D
S
E
H
K
L
E
T
S
Site 55
S905
S
E
H
K
L
E
T
S
S
G
R
V
L
G
R
Site 56
S906
E
H
K
L
E
T
S
S
G
R
V
L
G
R
F
Site 57
S918
G
R
F
R
G
K
G
S
G
G
L
N
L
G
N
Site 58
S929
N
L
G
N
F
F
A
S
R
K
G
Y
S
R
K
Site 59
Y933
F
F
A
S
R
K
G
Y
S
R
K
G
F
D
R
Site 60
S934
F
A
S
R
K
G
Y
S
R
K
G
F
D
R
L
Site 61
S942
R
K
G
F
D
R
L
S
T
E
G
S
D
Q
E
Site 62
T943
K
G
F
D
R
L
S
T
E
G
S
D
Q
E
K
Site 63
S946
D
R
L
S
T
E
G
S
D
Q
E
K
E
D
D
Site 64
S955
Q
E
K
E
D
D
G
S
E
S
E
E
E
Y
S
Site 65
S957
K
E
D
D
G
S
E
S
E
E
E
Y
S
A
P
Site 66
Y961
G
S
E
S
E
E
E
Y
S
A
P
L
P
A
L
Site 67
S962
S
E
S
E
E
E
Y
S
A
P
L
P
A
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation