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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIG1
Full Name:
DNA ligase 1
Alias:
DNA ligase I; DNL1; LIG-1; Ligase 1; Ligase I, DNA, ATP-dependent; Polydeoxyribonucleotide synthase [ATP]
Type:
DNA repair; Ligase; EC 6.5.1.1
Mass (Da):
101736
Number AA:
919
UniProt ID:
P18858
International Prot ID:
IPI00219841
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003910
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006260
GO:0009653
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
K
K
P
E
K
E
A
S
N
S
S
R
E
T
E
Site 2
S27
P
E
K
E
A
S
N
S
S
R
E
T
E
P
P
Site 3
T31
A
S
N
S
S
R
E
T
E
P
P
P
K
A
A
Site 4
S47
K
E
W
N
G
V
V
S
E
S
D
S
P
V
K
Site 5
S49
W
N
G
V
V
S
E
S
D
S
P
V
K
R
P
Site 6
S51
G
V
V
S
E
S
D
S
P
V
K
R
P
G
R
Site 7
S66
K
A
A
R
V
L
G
S
E
G
E
E
E
D
E
Site 8
S76
E
E
E
D
E
A
L
S
P
A
K
G
Q
K
P
Site 9
S88
Q
K
P
A
L
D
C
S
Q
V
S
P
P
R
P
Site 10
S91
A
L
D
C
S
Q
V
S
P
P
R
P
A
T
S
Site 11
T97
V
S
P
P
R
P
A
T
S
P
E
N
N
A
S
Site 12
S98
S
P
P
R
P
A
T
S
P
E
N
N
A
S
L
Site 13
S104
T
S
P
E
N
N
A
S
L
S
D
T
S
P
M
Site 14
S106
P
E
N
N
A
S
L
S
D
T
S
P
M
D
S
Site 15
T108
N
N
A
S
L
S
D
T
S
P
M
D
S
S
P
Site 16
S109
N
A
S
L
S
D
T
S
P
M
D
S
S
P
S
Site 17
S113
S
D
T
S
P
M
D
S
S
P
S
G
I
P
K
Site 18
S114
D
T
S
P
M
D
S
S
P
S
G
I
P
K
R
Site 19
S116
S
P
M
D
S
S
P
S
G
I
P
K
R
R
T
Site 20
T123
S
G
I
P
K
R
R
T
A
R
K
Q
L
P
K
Site 21
S141
Q
E
V
L
E
E
Q
S
E
D
E
D
R
E
A
Site 22
T159
K
E
E
E
E
E
E
T
P
K
E
S
L
T
E
Site 23
T165
E
T
P
K
E
S
L
T
E
A
E
V
A
T
E
Site 24
T182
G
E
D
G
D
Q
P
T
T
P
P
K
P
L
K
Site 25
T183
E
D
G
D
Q
P
T
T
P
P
K
P
L
K
T
Site 26
T190
T
P
P
K
P
L
K
T
S
K
A
E
T
P
T
Site 27
T195
L
K
T
S
K
A
E
T
P
T
E
S
V
S
E
Site 28
T197
T
S
K
A
E
T
P
T
E
S
V
S
E
P
E
Site 29
S199
K
A
E
T
P
T
E
S
V
S
E
P
E
V
A
Site 30
S201
E
T
P
T
E
S
V
S
E
P
E
V
A
T
K
Site 31
T218
L
Q
E
E
E
E
Q
T
K
P
P
R
R
A
P
Site 32
T227
P
P
R
R
A
P
K
T
L
S
S
F
F
T
P
Site 33
S229
R
R
A
P
K
T
L
S
S
F
F
T
P
R
K
Site 34
S230
R
A
P
K
T
L
S
S
F
F
T
P
R
K
P
Site 35
T233
K
T
L
S
S
F
F
T
P
R
K
P
A
V
K
Site 36
S264
A
E
G
P
L
D
P
S
G
Y
N
P
A
K
N
Site 37
Y266
G
P
L
D
P
S
G
Y
N
P
A
K
N
N
Y
Site 38
Y289
K
P
G
Q
K
V
P
Y
L
A
V
A
R
T
F
Site 39
T311
A
R
L
R
M
V
E
T
L
S
N
L
L
R
S
Site 40
S313
L
R
M
V
E
T
L
S
N
L
L
R
S
V
V
Site 41
S368
A
T
G
R
Q
L
E
S
V
R
A
E
A
A
E
Site 42
S386
V
G
L
V
A
E
N
S
R
S
T
Q
R
L
M
Site 43
S388
L
V
A
E
N
S
R
S
T
Q
R
L
M
L
P
Site 44
T389
V
A
E
N
S
R
S
T
Q
R
L
M
L
P
P
Site 45
S402
P
P
P
P
L
T
A
S
G
V
F
S
K
F
R
Site 46
T415
F
R
D
I
A
R
L
T
G
S
A
S
T
A
K
Site 47
S419
A
R
L
T
G
S
A
S
T
A
K
K
I
D
I
Site 48
S445
E
A
R
F
I
A
R
S
L
S
G
R
L
R
L
Site 49
S468
A
A
L
S
Q
A
V
S
L
T
P
P
G
Q
E
Site 50
T470
L
S
Q
A
V
S
L
T
P
P
G
Q
E
F
P
Site 51
T494
K
T
A
E
A
R
K
T
W
L
E
E
Q
G
M
Site 52
S535
L
P
E
H
C
K
L
S
P
G
I
P
L
K
P
Site 53
T548
K
P
M
L
A
H
P
T
R
G
I
S
E
V
L
Site 54
S552
A
H
P
T
R
G
I
S
E
V
L
K
R
F
E
Site 55
T564
R
F
E
E
A
A
F
T
C
E
Y
K
Y
D
G
Site 56
Y567
E
A
A
F
T
C
E
Y
K
Y
D
G
Q
R
A
Site 57
Y569
A
F
T
C
E
Y
K
Y
D
G
Q
R
A
Q
I
Site 58
T595
S
R
N
Q
E
D
N
T
G
K
Y
P
D
I
I
Site 59
Y598
Q
E
D
N
T
G
K
Y
P
D
I
I
S
R
I
Site 60
S603
G
K
Y
P
D
I
I
S
R
I
P
K
I
K
L
Site 61
T639
I
Q
P
F
Q
V
L
T
T
R
K
R
K
E
V
Site 62
S649
K
R
K
E
V
D
A
S
E
I
Q
V
Q
V
C
Site 63
S676
S
L
V
R
E
P
L
S
R
R
R
Q
L
L
R
Site 64
S714
I
A
E
F
L
E
Q
S
V
K
D
S
C
E
G
Site 65
S718
L
E
Q
S
V
K
D
S
C
E
G
L
M
V
K
Site 66
T732
K
T
L
D
V
D
A
T
Y
E
I
A
K
R
S
Site 67
Y733
T
L
D
V
D
A
T
Y
E
I
A
K
R
S
H
Site 68
Y749
W
L
K
L
K
K
D
Y
L
D
G
V
G
D
T
Site 69
Y775
R
G
K
R
A
G
R
Y
G
G
F
L
L
A
S
Site 70
S782
Y
G
G
F
L
L
A
S
Y
D
E
D
S
E
E
Site 71
Y783
G
G
F
L
L
A
S
Y
D
E
D
S
E
E
L
Site 72
S787
L
A
S
Y
D
E
D
S
E
E
L
Q
A
I
C
Site 73
T798
Q
A
I
C
K
L
G
T
G
F
S
D
E
E
L
Site 74
S801
C
K
L
G
T
G
F
S
D
E
E
L
E
E
H
Site 75
S811
E
L
E
E
H
H
Q
S
L
K
A
L
V
L
P
Site 76
S819
L
K
A
L
V
L
P
S
P
R
P
Y
V
R
I
Site 77
S852
K
C
A
D
L
S
L
S
P
I
Y
P
A
A
R
Site 78
S864
A
A
R
G
L
V
D
S
D
K
G
I
S
L
R
Site 79
S869
V
D
S
D
K
G
I
S
L
R
F
P
R
F
I
Site 80
T889
K
Q
P
E
Q
A
T
T
S
A
Q
V
A
C
L
Site 81
S890
Q
P
E
Q
A
T
T
S
A
Q
V
A
C
L
Y
Site 82
Y897
S
A
Q
V
A
C
L
Y
R
K
Q
S
Q
I
Q
Site 83
S901
A
C
L
Y
R
K
Q
S
Q
I
Q
N
Q
Q
G
Site 84
S911
Q
N
Q
Q
G
E
D
S
G
S
D
P
E
D
T
Site 85
S913
Q
Q
G
E
D
S
G
S
D
P
E
D
T
Y
_
Site 86
T918
S
G
S
D
P
E
D
T
Y
_
_
_
_
_
_
Site 87
Y919
G
S
D
P
E
D
T
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation