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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGFBP-3
Full Name:
Insulin-like growth factor-binding protein 3
Alias:
Acid stable subunit of the 140 K IGF complex; Binding protein 29; Binding protein 53; BP-53; Growth hormone-dependent binding protein; IBP3; IBP-3; IGF-binding protein 3; IGFBP3; Insulin-like growth factor binding protein 3; Insulin-like growth factor binding protein 3 precursor
Type:
Secreted protein
Mass (Da):
31674
Number AA:
291
UniProt ID:
P17936
International Prot ID:
IPI00018305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016942
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0031994
GO:0046872
GO:0008160
PhosphoSite+
KinaseNET
Biological Process:
GO:0001933
GO:0009968
GO:0014912
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
Q
R
A
R
P
T
L
W
A
A
A
L
T
Site 2
Y84
E
G
Q
P
C
G
I
Y
T
E
R
C
G
S
G
Site 3
T85
G
Q
P
C
G
I
Y
T
E
R
C
G
S
G
L
Site 4
S90
I
Y
T
E
R
C
G
S
G
L
R
C
Q
P
S
Site 5
S97
S
G
L
R
C
Q
P
S
P
D
E
A
R
P
L
Site 6
S138
P
P
A
P
G
N
A
S
E
S
E
E
D
R
S
Site 7
S140
A
P
G
N
A
S
E
S
E
E
D
R
S
A
G
Site 8
S145
S
E
S
E
E
D
R
S
A
G
S
V
E
S
P
Site 9
S148
E
E
D
R
S
A
G
S
V
E
S
P
S
V
S
Site 10
S151
R
S
A
G
S
V
E
S
P
S
V
S
S
T
H
Site 11
S153
A
G
S
V
E
S
P
S
V
S
S
T
H
R
V
Site 12
S155
S
V
E
S
P
S
V
S
S
T
H
R
V
S
D
Site 13
S156
V
E
S
P
S
V
S
S
T
H
R
V
S
D
P
Site 14
T157
E
S
P
S
V
S
S
T
H
R
V
S
D
P
K
Site 15
S161
V
S
S
T
H
R
V
S
D
P
K
F
H
P
L
Site 16
S183
K
K
G
H
A
K
D
S
Q
R
Y
K
V
D
Y
Site 17
Y190
S
Q
R
Y
K
V
D
Y
E
S
Q
S
T
D
T
Site 18
S192
R
Y
K
V
D
Y
E
S
Q
S
T
D
T
Q
N
Site 19
S194
K
V
D
Y
E
S
Q
S
T
D
T
Q
N
F
S
Site 20
T195
V
D
Y
E
S
Q
S
T
D
T
Q
N
F
S
S
Site 21
T197
Y
E
S
Q
S
T
D
T
Q
N
F
S
S
E
S
Site 22
S201
S
T
D
T
Q
N
F
S
S
E
S
K
R
E
T
Site 23
S202
T
D
T
Q
N
F
S
S
E
S
K
R
E
T
E
Site 24
S204
T
Q
N
F
S
S
E
S
K
R
E
T
E
Y
G
Site 25
T208
S
S
E
S
K
R
E
T
E
Y
G
P
C
R
R
Site 26
Y210
E
S
K
R
E
T
E
Y
G
P
C
R
R
E
M
Site 27
T220
C
R
R
E
M
E
D
T
L
N
H
L
K
F
L
Site 28
Y246
N
C
D
K
K
G
F
Y
K
K
K
Q
C
R
P
Site 29
S254
K
K
K
Q
C
R
P
S
K
G
R
K
R
G
F
Site 30
Y275
Y
G
Q
P
L
P
G
Y
T
T
K
G
K
E
D
Site 31
Y286
G
K
E
D
V
H
C
Y
S
M
Q
S
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation