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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PFKL
Full Name:
6-phosphofructokinase, liver type
Alias:
K6PL; PFK-B; phosphofructo-1-kinase isozyme B; phosphofructokinase 1; phosphofructokinase, liver; phosphohexokinase
Type:
EC 2.7.1.11; Kinase (non-protein); Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway
Mass (Da):
85018
Number AA:
780
UniProt ID:
P17858
International Prot ID:
IPI00784216
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005945
Uniprot
OncoNet
Molecular Function:
GO:0003872
GO:0005524
GO:0070095
PhosphoSite+
KinaseNET
Biological Process:
GO:0006002
GO:0006096
GO:0051259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
D
L
E
K
L
R
A
S
G
A
G
K
A
I
G
Site 2
T82
N
I
I
Q
L
G
G
T
I
I
G
S
A
R
C
Site 3
T93
S
A
R
C
K
A
F
T
T
R
E
G
R
R
A
Site 4
Y103
E
G
R
R
A
A
A
Y
N
L
V
Q
H
G
I
Site 5
T123
I
G
G
D
G
S
L
T
G
A
N
I
F
R
S
Site 6
S130
T
G
A
N
I
F
R
S
E
W
G
S
L
L
E
Site 7
S146
L
V
A
E
G
K
I
S
E
T
T
A
R
T
Y
Site 8
T148
A
E
G
K
I
S
E
T
T
A
R
T
Y
S
H
Site 9
T149
E
G
K
I
S
E
T
T
A
R
T
Y
S
H
L
Site 10
Y153
S
E
T
T
A
R
T
Y
S
H
L
N
I
A
G
Site 11
S154
E
T
T
A
R
T
Y
S
H
L
N
I
A
G
L
Site 12
T193
M
E
V
I
D
A
I
T
T
T
A
Q
S
H
Q
Site 13
T202
T
A
Q
S
H
Q
R
T
F
V
L
E
V
M
G
Site 14
S252
E
R
L
G
E
T
R
S
R
G
S
R
L
N
I
Site 15
S255
G
E
T
R
S
R
G
S
R
L
N
I
I
I
I
Site 16
S275
D
R
N
G
K
P
I
S
S
S
Y
V
K
D
L
Site 17
S277
N
G
K
P
I
S
S
S
Y
V
K
D
L
V
V
Site 18
Y278
G
K
P
I
S
S
S
Y
V
K
D
L
V
V
Q
Site 19
T304
G
H
V
Q
R
G
G
T
P
S
A
F
D
R
I
Site 20
S306
V
Q
R
G
G
T
P
S
A
F
D
R
I
L
S
Site 21
S313
S
A
F
D
R
I
L
S
S
K
M
G
M
E
A
Site 22
T371
D
K
R
F
D
E
A
T
Q
L
R
G
G
S
F
Site 23
S377
A
T
Q
L
R
G
G
S
F
E
N
N
W
N
I
Site 24
S398
Q
K
P
P
K
E
K
S
N
F
S
L
A
I
L
Site 25
S401
P
K
E
K
S
N
F
S
L
A
I
L
N
V
G
Site 26
T424
A
V
R
S
A
V
R
T
G
I
S
H
G
H
T
Site 27
T431
T
G
I
S
H
G
H
T
V
Y
V
V
H
D
G
Site 28
Y433
I
S
H
G
H
T
V
Y
V
V
H
D
G
F
E
Site 29
S464
G
W
L
G
R
G
G
S
M
L
G
T
K
R
T
Site 30
T468
R
G
G
S
M
L
G
T
K
R
T
L
P
K
G
Site 31
T471
S
M
L
G
T
K
R
T
L
P
K
G
Q
L
E
Site 32
S479
L
P
K
G
Q
L
E
S
I
V
E
N
I
R
I
Site 33
T535
I
S
N
N
V
P
G
T
D
F
S
L
G
S
D
Site 34
S538
N
V
P
G
T
D
F
S
L
G
S
D
T
A
V
Site 35
S541
G
T
D
F
S
L
G
S
D
T
A
V
N
A
A
Site 36
S558
S
C
D
R
I
K
Q
S
A
S
G
T
K
R
R
Site 37
T562
I
K
Q
S
A
S
G
T
K
R
R
V
F
I
V
Site 38
Y575
I
V
E
T
M
G
G
Y
C
G
Y
L
A
T
V
Site 39
T617
H
M
T
E
K
M
K
T
D
I
Q
R
G
L
V
Site 40
Y633
R
N
E
K
C
H
D
Y
Y
T
T
E
F
L
Y
Site 41
Y634
N
E
K
C
H
D
Y
Y
T
T
E
F
L
Y
N
Site 42
Y640
Y
Y
T
T
E
F
L
Y
N
L
Y
S
S
E
G
Site 43
Y643
T
E
F
L
Y
N
L
Y
S
S
E
G
K
G
V
Site 44
S644
E
F
L
Y
N
L
Y
S
S
E
G
K
G
V
F
Site 45
S645
F
L
Y
N
L
Y
S
S
E
G
K
G
V
F
D
Site 46
T655
K
G
V
F
D
C
R
T
N
V
L
G
H
L
Q
Site 47
T668
L
Q
Q
G
G
A
P
T
P
F
D
R
N
Y
G
Site 48
Y674
P
T
P
F
D
R
N
Y
G
T
K
L
G
V
K
Site 49
S687
V
K
A
M
L
W
L
S
E
K
L
R
E
V
Y
Site 50
Y694
S
E
K
L
R
E
V
Y
R
K
G
R
V
F
A
Site 51
S720
K
K
K
A
V
A
F
S
P
V
T
E
L
K
K
Site 52
S757
M
L
A
Q
Y
R
I
S
M
A
A
Y
V
S
G
Site 53
Y761
Y
R
I
S
M
A
A
Y
V
S
G
E
L
E
H
Site 54
T770
S
G
E
L
E
H
V
T
R
R
T
L
S
M
D
Site 55
T773
L
E
H
V
T
R
R
T
L
S
M
D
K
G
F
Site 56
S775
H
V
T
R
R
T
L
S
M
D
K
G
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation