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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX5
Full Name:
Probable ATP-dependent RNA helicase DDX5
Alias:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD box protein 5; DEAD-box protein 5; DEAD-box protein p68; G17P1; HELR; HLR1; P68; Probable RNA-dependent helicase p68
Type:
Helicase; RNA binding protein; Nuclear receptor co-regulator; EC 3.6.1.-
Mass (Da):
69148
Number AA:
614
UniProt ID:
P17844
International Prot ID:
IPI00017617
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005681
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0016049
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
G
Y
S
S
D
R
D
R
G
R
D
Site 2
S24
G
A
P
R
F
G
G
S
R
A
G
P
L
S
G
Site 3
S30
G
S
R
A
G
P
L
S
G
K
K
F
G
N
P
Site 4
Y59
P
K
F
E
K
N
F
Y
Q
E
H
P
D
L
A
Site 5
T69
H
P
D
L
A
R
R
T
A
Q
E
V
E
T
Y
Site 6
T75
R
T
A
Q
E
V
E
T
Y
R
R
S
K
E
I
Site 7
Y76
T
A
Q
E
V
E
T
Y
R
R
S
K
E
I
T
Site 8
S79
E
V
E
T
Y
R
R
S
K
E
I
T
V
R
G
Site 9
T83
Y
R
R
S
K
E
I
T
V
R
G
H
N
C
P
Site 10
Y97
P
K
P
V
L
N
F
Y
E
A
N
F
P
A
N
Site 11
T145
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
Site 12
Y190
V
Q
Q
V
A
A
E
Y
C
R
A
C
R
L
K
Site 13
T199
R
A
C
R
L
K
S
T
C
I
Y
G
G
A
P
Site 14
Y202
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Site 15
T224
G
V
E
I
C
I
A
T
P
G
R
L
I
D
F
Site 16
T237
D
F
L
E
C
G
K
T
N
L
R
R
T
T
Y
Site 17
T242
G
K
T
N
L
R
R
T
T
Y
L
V
L
D
E
Site 18
T243
K
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
Site 19
Y244
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
Site 20
T281
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
Site 21
Y297
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
A
Site 22
S338
R
L
M
E
E
I
M
S
E
K
E
N
K
T
I
Site 23
T344
M
S
E
K
E
N
K
T
I
V
F
V
E
T
K
Site 24
T350
K
T
I
V
F
V
E
T
K
R
R
C
D
E
L
Site 25
T358
K
R
R
C
D
E
L
T
R
K
M
R
R
D
G
Site 26
Y416
D
V
K
F
V
I
N
Y
D
Y
P
N
S
S
E
Site 27
Y418
K
F
V
I
N
Y
D
Y
P
N
S
S
E
D
Y
Site 28
Y425
Y
P
N
S
S
E
D
Y
I
H
R
I
G
R
T
Site 29
S435
R
I
G
R
T
A
R
S
T
K
T
G
T
A
Y
Site 30
T436
I
G
R
T
A
R
S
T
K
T
G
T
A
Y
T
Site 31
Y442
S
T
K
T
G
T
A
Y
T
F
F
T
P
N
N
Site 32
T443
T
K
T
G
T
A
Y
T
F
F
T
P
N
N
I
Site 33
T446
G
T
A
Y
T
F
F
T
P
N
N
I
K
Q
V
Site 34
S458
K
Q
V
S
D
L
I
S
V
L
R
E
A
N
Q
Site 35
S480
Q
L
V
E
D
R
G
S
G
R
S
R
G
R
G
Site 36
S483
E
D
R
G
S
G
R
S
R
G
R
G
G
M
K
Site 37
Y497
K
D
D
R
R
D
R
Y
S
A
G
K
R
G
G
Site 38
S498
D
D
R
R
D
R
Y
S
A
G
K
R
G
G
F
Site 39
T507
G
K
R
G
G
F
N
T
F
R
D
R
E
N
Y
Site 40
Y514
T
F
R
D
R
E
N
Y
D
R
G
Y
S
S
L
Site 41
Y518
R
E
N
Y
D
R
G
Y
S
S
L
L
K
R
D
Site 42
S519
E
N
Y
D
R
G
Y
S
S
L
L
K
R
D
F
Site 43
S520
N
Y
D
R
G
Y
S
S
L
L
K
R
D
F
G
Site 44
T530
K
R
D
F
G
A
K
T
Q
N
G
V
Y
S
A
Site 45
Y535
A
K
T
Q
N
G
V
Y
S
A
A
N
Y
T
N
Site 46
Y540
G
V
Y
S
A
A
N
Y
T
N
G
S
F
G
S
Site 47
S544
A
A
N
Y
T
N
G
S
F
G
S
N
F
V
S
Site 48
S557
V
S
A
G
I
Q
T
S
F
R
T
G
N
P
T
Site 49
T560
G
I
Q
T
S
F
R
T
G
N
P
T
G
T
Y
Site 50
T564
S
F
R
T
G
N
P
T
G
T
Y
Q
N
G
Y
Site 51
Y567
T
G
N
P
T
G
T
Y
Q
N
G
Y
D
S
T
Site 52
Y571
T
G
T
Y
Q
N
G
Y
D
S
T
Q
Q
Y
G
Site 53
Y577
G
Y
D
S
T
Q
Q
Y
G
S
N
V
P
N
M
Site 54
Y593
N
G
M
N
Q
Q
A
Y
A
Y
P
A
T
A
A
Site 55
Y595
M
N
Q
Q
A
Y
A
Y
P
A
T
A
A
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation