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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN2
Full Name:
Tyrosine-protein phosphatase non-receptor type 2
Alias:
EC 3.1.3.48; Protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP
Type:
Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Mass (Da):
48528
Number AA:
415
UniProt ID:
P17706
International Prot ID:
IPI00218788
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
R
E
F
E
E
L
D
T
Q
R
R
W
Q
P
L
Site 2
Y22
Q
R
R
W
Q
P
L
Y
L
E
I
R
N
E
S
Site 3
S29
Y
L
E
I
R
N
E
S
H
D
Y
P
H
R
V
Site 4
Y32
I
R
N
E
S
H
D
Y
P
H
R
V
A
K
F
Site 5
Y48
E
N
R
N
R
N
R
Y
R
D
V
S
P
Y
D
Site 6
S52
R
N
R
Y
R
D
V
S
P
Y
D
H
S
R
V
Site 7
Y54
R
Y
R
D
V
S
P
Y
D
H
S
R
V
K
L
Site 8
Y68
L
Q
N
A
E
N
D
Y
I
N
A
S
L
V
D
Site 9
S72
E
N
D
Y
I
N
A
S
L
V
D
I
E
E
A
Site 10
S82
D
I
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
Site 11
Y83
I
E
E
A
Q
R
S
Y
I
L
T
Q
G
P
L
Site 12
T86
A
Q
R
S
Y
I
L
T
Q
G
P
L
P
N
T
Site 13
S142
L
F
K
E
T
G
F
S
V
K
L
L
S
E
D
Site 14
S147
G
F
S
V
K
L
L
S
E
D
V
K
S
Y
Y
Site 15
Y153
L
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
Site 16
Y154
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
L
Site 17
S166
L
Q
L
E
N
I
N
S
G
E
T
R
T
I
S
Site 18
S188
P
D
F
G
V
P
E
S
P
A
S
F
L
N
F
Site 19
S202
F
L
F
K
V
R
E
S
G
S
L
N
P
D
H
Site 20
S204
F
K
V
R
E
S
G
S
L
N
P
D
H
G
P
Site 21
T261
Y
R
M
G
L
I
Q
T
P
D
Q
L
R
F
S
Site 22
S268
T
P
D
Q
L
R
F
S
Y
M
A
I
I
E
G
Site 23
Y269
P
D
Q
L
R
F
S
Y
M
A
I
I
E
G
A
Site 24
S284
K
C
I
K
G
D
S
S
I
Q
K
R
W
K
E
Site 25
S293
Q
K
R
W
K
E
L
S
K
E
D
L
S
P
A
Site 26
S298
E
L
S
K
E
D
L
S
P
A
F
D
H
S
P
Site 27
S304
L
S
P
A
F
D
H
S
P
N
K
I
M
T
E
Site 28
Y313
N
K
I
M
T
E
K
Y
N
G
N
R
I
G
L
Site 29
T326
G
L
E
E
E
K
L
T
G
D
R
C
T
G
L
Site 30
T331
K
L
T
G
D
R
C
T
G
L
S
S
K
M
Q
Site 31
S334
G
D
R
C
T
G
L
S
S
K
M
Q
D
T
M
Site 32
T340
L
S
S
K
M
Q
D
T
M
E
E
N
S
E
S
Site 33
S347
T
M
E
E
N
S
E
S
A
L
R
K
R
I
R
Site 34
T360
I
R
E
D
R
K
A
T
T
A
Q
K
V
Q
Q
Site 35
Y384
R
K
R
K
R
W
L
Y
W
Q
P
I
L
T
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation