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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN2
Full Name:
Calpain-2 catalytic subunit
Alias:
Calcium-activated neutral proteinase; Calpain 2 (m/II) large subunit; Calpain 2, large [catalytic] subunit; Calpain large polypeptide L2; CAN2; CANP; CANPL2; CANPml; M-calpain; MCANP; Millimolar-calpain
Type:
Protease; EC 3.4.22.53
Mass (Da):
79878
Number AA:
700
UniProt ID:
P17655
International Prot ID:
IPI00289758
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
A
A
E
G
L
G
S
H
E
R
A
I
K
Y
Site 2
Y27
S
H
E
R
A
I
K
Y
L
N
Q
D
Y
E
A
Site 3
Y32
I
K
Y
L
N
Q
D
Y
E
A
L
R
N
E
C
Site 4
S50
G
T
L
F
Q
D
P
S
F
P
A
I
P
S
A
Site 5
Y66
G
F
K
E
L
G
P
Y
S
S
K
T
R
G
I
Site 6
S68
K
E
L
G
P
Y
S
S
K
T
R
G
I
E
W
Site 7
T70
L
G
P
Y
S
S
K
T
R
G
I
E
W
K
R
Site 8
T79
G
I
E
W
K
R
P
T
E
I
C
A
D
P
Q
Site 9
S130
R
V
V
P
L
N
Q
S
F
Q
E
N
Y
A
G
Site 10
T160
V
V
D
D
R
L
P
T
K
D
G
E
L
L
F
Site 11
S178
A
E
G
S
E
F
W
S
A
L
L
E
K
A
Y
Site 12
Y192
Y
A
K
I
N
G
C
Y
E
A
L
S
G
G
A
Site 13
S196
N
G
C
Y
E
A
L
S
G
G
A
T
T
E
G
Site 14
T200
E
A
L
S
G
G
A
T
T
E
G
F
E
D
F
Site 15
T208
T
E
G
F
E
D
F
T
G
G
I
A
E
W
Y
Site 16
Y215
T
G
G
I
A
E
W
Y
E
L
K
K
P
P
P
Site 17
S236
Q
K
A
L
Q
K
G
S
L
L
G
C
S
I
D
Site 18
S250
D
I
T
S
A
A
D
S
E
A
I
T
F
Q
K
Site 19
T254
A
A
D
S
E
A
I
T
F
Q
K
L
V
K
G
Site 20
S274
T
G
A
E
E
V
E
S
N
G
S
L
Q
K
L
Site 21
S277
E
E
V
E
S
N
G
S
L
Q
K
L
I
R
I
Site 22
T316
P
E
E
R
E
R
L
T
R
R
H
E
D
G
E
Site 23
Y335
F
S
D
F
L
R
H
Y
S
R
L
E
I
C
N
Site 24
S336
S
D
F
L
R
H
Y
S
R
L
E
I
C
N
L
Site 25
T344
R
L
E
I
C
N
L
T
P
D
T
L
T
S
D
Site 26
T347
I
C
N
L
T
P
D
T
L
T
S
D
T
Y
K
Site 27
S350
L
T
P
D
T
L
T
S
D
T
Y
K
K
W
K
Site 28
Y353
D
T
L
T
S
D
T
Y
K
K
W
K
L
T
K
Site 29
S369
D
G
N
W
R
R
G
S
T
A
G
G
C
R
N
Site 30
T370
G
N
W
R
R
G
S
T
A
G
G
C
R
N
Y
Site 31
Y377
T
A
G
G
C
R
N
Y
P
N
T
F
W
M
N
Site 32
Y387
T
F
W
M
N
P
Q
Y
L
I
K
L
E
E
E
Site 33
S403
E
D
E
E
D
G
E
S
G
C
T
F
L
V
G
Site 34
Y434
H
T
I
G
F
G
I
Y
E
V
P
E
E
L
S
Site 35
T455
L
S
K
N
F
F
L
T
N
R
A
R
E
R
S
Site 36
S462
T
N
R
A
R
E
R
S
D
T
F
I
N
L
R
Site 37
T464
R
A
R
E
R
S
D
T
F
I
N
L
R
E
V
Site 38
T488
E
Y
I
L
V
P
S
T
F
E
P
N
K
D
G
Site 39
Y509
F
S
E
K
K
A
D
Y
Q
A
V
D
D
E
I
Site 40
S526
N
L
E
E
F
D
I
S
E
D
D
I
D
D
G
Site 41
S569
A
K
R
Q
D
I
K
S
D
G
F
S
I
E
T
Site 42
S573
D
I
K
S
D
G
F
S
I
E
T
C
K
I
M
Site 43
S586
I
M
V
D
M
L
D
S
D
G
S
G
K
L
G
Site 44
S589
D
M
L
D
S
D
G
S
G
K
L
G
L
K
E
Site 45
Y607
L
W
T
K
I
Q
K
Y
Q
K
I
Y
R
E
I
Site 46
Y611
I
Q
K
Y
Q
K
I
Y
R
E
I
D
V
D
R
Site 47
S619
R
E
I
D
V
D
R
S
G
T
M
N
S
Y
E
Site 48
T621
I
D
V
D
R
S
G
T
M
N
S
Y
E
M
R
Site 49
S624
D
R
S
G
T
M
N
S
Y
E
M
R
K
A
L
Site 50
Y625
R
S
G
T
M
N
S
Y
E
M
R
K
A
L
E
Site 51
T686
L
D
P
E
N
T
G
T
I
E
L
D
L
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation