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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYN1
Full Name:
Synapsin-1
Alias:
Brain protein 4.1; SYN-1; Synapsin I
Type:
Vesicle protein
Mass (Da):
74111
Number AA:
705
UniProt ID:
P17600
International Prot ID:
IPI00300568
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030054
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
Y
L
R
R
R
L
S
D
S
N
F
M
A
N
Site 2
S11
L
R
R
R
L
S
D
S
N
F
M
A
N
L
P
Site 3
S39
P
P
P
P
G
A
H
S
P
G
A
T
P
G
P
Site 4
T43
G
A
H
S
P
G
A
T
P
G
P
G
T
A
T
Site 5
T50
T
P
G
P
G
T
A
T
A
E
R
S
S
G
V
Site 6
S55
T
A
T
A
E
R
S
S
G
V
A
P
A
A
S
Site 7
S62
S
G
V
A
P
A
A
S
P
A
A
P
S
P
G
Site 8
S67
A
A
S
P
A
A
P
S
P
G
S
S
G
G
G
Site 9
S70
P
A
A
P
S
P
G
S
S
G
G
G
G
F
F
Site 10
S71
A
A
P
S
P
G
S
S
G
G
G
G
F
F
S
Site 11
S78
S
G
G
G
G
F
F
S
S
L
S
N
A
V
K
Site 12
S79
G
G
G
G
F
F
S
S
L
S
N
A
V
K
Q
Site 13
S81
G
G
F
F
S
S
L
S
N
A
V
K
Q
T
T
Site 14
S103
S
E
Q
V
G
G
G
S
G
G
A
G
R
G
G
Site 15
Y129
P
H
T
D
W
A
K
Y
F
K
G
K
K
I
H
Site 16
S149
K
V
E
Q
A
E
F
S
D
L
N
L
V
A
H
Site 17
S162
A
H
A
N
G
G
F
S
V
D
M
E
V
L
R
Site 18
Y198
S
M
A
R
N
G
D
Y
R
S
L
V
I
G
L
Site 19
S200
A
R
N
G
D
Y
R
S
L
V
I
G
L
Q
Y
Site 20
S218
P
S
V
N
S
L
H
S
V
Y
N
F
C
D
K
Site 21
T250
E
F
P
L
I
D
Q
T
F
Y
P
N
H
K
E
Site 22
Y252
P
L
I
D
Q
T
F
Y
P
N
H
K
E
M
L
Site 23
S260
P
N
H
K
E
M
L
S
S
T
T
Y
P
V
V
Site 24
S261
N
H
K
E
M
L
S
S
T
T
Y
P
V
V
V
Site 25
T262
H
K
E
M
L
S
S
T
T
Y
P
V
V
V
K
Site 26
S275
V
K
M
G
H
A
H
S
G
M
G
K
V
K
V
Site 27
Y301
V
V
A
L
T
K
T
Y
A
T
A
E
P
F
I
Site 28
Y312
E
P
F
I
D
A
K
Y
D
V
R
V
Q
K
I
Site 29
Y326
I
G
Q
N
Y
K
A
Y
M
R
T
S
V
S
G
Site 30
S332
A
Y
M
R
T
S
V
S
G
N
W
K
T
N
T
Site 31
T337
S
V
S
G
N
W
K
T
N
T
G
S
A
M
L
Site 32
T339
S
G
N
W
K
T
N
T
G
S
A
M
L
E
Q
Site 33
S341
N
W
K
T
N
T
G
S
A
M
L
E
Q
I
A
Site 34
Y353
Q
I
A
M
S
D
R
Y
K
L
W
V
D
T
C
Site 35
S390
H
I
I
E
V
V
G
S
S
M
P
L
I
G
D
Site 36
S391
I
I
E
V
V
G
S
S
M
P
L
I
G
D
H
Site 37
S427
R
Q
R
Q
R
D
A
S
P
G
R
G
S
H
G
Site 38
S432
D
A
S
P
G
R
G
S
H
G
Q
T
P
S
P
Site 39
T436
G
R
G
S
H
G
Q
T
P
S
P
G
A
L
P
Site 40
S438
G
S
H
G
Q
T
P
S
P
G
A
L
P
L
G
Site 41
T448
A
L
P
L
G
R
Q
T
S
Q
Q
P
A
G
P
Site 42
S449
L
P
L
G
R
Q
T
S
Q
Q
P
A
G
P
P
Site 43
S494
P
Q
G
Q
Q
H
L
S
G
L
G
P
P
A
G
Site 44
S502
G
L
G
P
P
A
G
S
P
L
P
Q
R
L
P
Site 45
S510
P
L
P
Q
R
L
P
S
P
T
S
A
P
Q
Q
Site 46
T512
P
Q
R
L
P
S
P
T
S
A
P
Q
Q
P
A
Site 47
S513
Q
R
L
P
S
P
T
S
A
P
Q
Q
P
A
S
Site 48
S520
S
A
P
Q
Q
P
A
S
Q
A
A
P
P
T
Q
Site 49
S533
T
Q
G
Q
G
R
Q
S
R
P
V
A
G
G
P
Site 50
S551
P
A
A
R
P
P
A
S
P
S
P
Q
R
Q
A
Site 51
S553
A
R
P
P
A
S
P
S
P
Q
R
Q
A
G
P
Site 52
T567
P
P
Q
A
T
R
Q
T
S
V
S
G
P
A
P
Site 53
S568
P
Q
A
T
R
Q
T
S
V
S
G
P
A
P
P
Site 54
S570
A
T
R
Q
T
S
V
S
G
P
A
P
P
K
A
Site 55
S578
G
P
A
P
P
K
A
S
G
A
P
P
G
G
Q
Site 56
S605
A
G
P
T
R
Q
A
S
Q
A
G
P
V
P
R
Site 57
T613
Q
A
G
P
V
P
R
T
G
P
P
T
T
Q
Q
Site 58
T617
V
P
R
T
G
P
P
T
T
Q
Q
P
R
P
S
Site 59
T618
P
R
T
G
P
P
T
T
Q
Q
P
R
P
S
G
Site 60
S624
T
T
Q
Q
P
R
P
S
G
P
G
P
A
G
R
Site 61
S641
P
Q
L
A
Q
K
P
S
Q
D
V
P
P
P
A
Site 62
S663
P
H
P
Q
L
N
K
S
Q
S
L
T
N
A
F
Site 63
S665
P
Q
L
N
K
S
Q
S
L
T
N
A
F
N
L
Site 64
T667
L
N
K
S
Q
S
L
T
N
A
F
N
L
P
E
Site 65
S681
E
P
A
P
P
R
P
S
L
S
Q
D
E
V
K
Site 66
S683
A
P
P
R
P
S
L
S
Q
D
E
V
K
A
E
Site 67
T691
Q
D
E
V
K
A
E
T
I
R
S
L
R
K
S
Site 68
S694
V
K
A
E
T
I
R
S
L
R
K
S
F
A
S
Site 69
S698
T
I
R
S
L
R
K
S
F
A
S
L
F
S
D
Site 70
S701
S
L
R
K
S
F
A
S
L
F
S
D
_
_
_
Site 71
S704
K
S
F
A
S
L
F
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation