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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv1.2
Full Name:
Potassium voltage-gated channel subfamily A member 2
Alias:
CIK2; HBK5; HK4; HUKIV; HuKIV; KCNA2; MK2; NGK1; Potassium voltage-gated channel, shaker-related subfamily, member 2; RBK2; Voltage-gated potassium channel Kv1.2; Voltage-gated potassium channel Kv12; Voltage-gated potassium channel subunit Kv1.2
Type:
Channel protein, potassium
Mass (Da):
56717
Number AA:
499
UniProt ID:
P16389
International Prot ID:
IPI00028134
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005251
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
L
P
G
H
P
Q
D
T
Y
D
P
E
A
D
H
Site 2
Y23
P
G
H
P
Q
D
T
Y
D
P
E
A
D
H
E
Site 3
S40
E
R
V
V
I
N
I
S
G
L
R
F
E
T
Q
Site 4
T46
I
S
G
L
R
F
E
T
Q
L
K
T
L
A
Q
Site 5
T50
R
F
E
T
Q
L
K
T
L
A
Q
F
P
E
T
Site 6
T57
T
L
A
Q
F
P
E
T
L
L
G
D
P
K
K
Site 7
Y68
D
P
K
K
R
M
R
Y
F
D
P
L
R
N
E
Site 8
Y76
F
D
P
L
R
N
E
Y
F
F
D
R
N
R
P
Site 9
S84
F
F
D
R
N
R
P
S
F
D
A
I
L
Y
Y
Site 10
Y90
P
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
Site 11
Y91
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
Site 12
Y92
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
R
Site 13
S94
A
I
L
Y
Y
Y
Q
S
G
G
R
L
R
R
P
Site 14
S110
N
V
P
L
D
I
F
S
E
E
I
R
F
Y
E
Site 15
Y116
F
S
E
E
I
R
F
Y
E
L
G
E
E
A
M
Site 16
Y132
M
F
R
E
D
E
G
Y
I
K
E
E
E
R
P
Site 17
Y155
Q
V
W
L
L
F
E
Y
P
E
S
S
G
P
A
Site 18
T201
D
M
H
G
S
G
V
T
F
H
T
Y
S
N
S
Site 19
T204
G
S
G
V
T
F
H
T
Y
S
N
S
T
I
G
Site 20
Y205
S
G
V
T
F
H
T
Y
S
N
S
T
I
G
Y
Site 21
S208
T
F
H
T
Y
S
N
S
T
I
G
Y
Q
Q
S
Site 22
Y212
Y
S
N
S
T
I
G
Y
Q
Q
S
T
S
F
T
Site 23
S215
S
T
I
G
Y
Q
Q
S
T
S
F
T
D
P
F
Site 24
S217
I
G
Y
Q
Q
S
T
S
F
T
D
P
F
F
I
Site 25
T219
Y
Q
Q
S
T
S
F
T
D
P
F
F
I
V
E
Site 26
S308
V
F
R
I
F
K
L
S
R
H
S
K
G
L
Q
Site 27
S311
I
F
K
L
S
R
H
S
K
G
L
Q
I
L
G
Site 28
S356
A
E
A
D
E
R
E
S
Q
F
P
S
I
P
D
Site 29
Y415
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T
E
Site 30
Y417
V
S
N
F
N
Y
F
Y
H
R
E
T
E
G
E
Site 31
T421
N
Y
F
Y
H
R
E
T
E
G
E
E
Q
A
Q
Site 32
Y429
E
G
E
E
Q
A
Q
Y
L
Q
V
T
S
C
P
Site 33
T433
Q
A
Q
Y
L
Q
V
T
S
C
P
K
I
P
S
Site 34
S434
A
Q
Y
L
Q
V
T
S
C
P
K
I
P
S
S
Site 35
S440
T
S
C
P
K
I
P
S
S
P
D
L
K
K
S
Site 36
S441
S
C
P
K
I
P
S
S
P
D
L
K
K
S
R
Site 37
S447
S
S
P
D
L
K
K
S
R
S
A
S
T
I
S
Site 38
S449
P
D
L
K
K
S
R
S
A
S
T
I
S
K
S
Site 39
S451
L
K
K
S
R
S
A
S
T
I
S
K
S
D
Y
Site 40
T452
K
K
S
R
S
A
S
T
I
S
K
S
D
Y
M
Site 41
S454
S
R
S
A
S
T
I
S
K
S
D
Y
M
E
I
Site 42
S456
S
A
S
T
I
S
K
S
D
Y
M
E
I
Q
E
Site 43
Y458
S
T
I
S
K
S
D
Y
M
E
I
Q
E
G
V
Site 44
T479
F
R
E
E
N
L
K
T
A
N
C
T
L
A
N
Site 45
Y489
C
T
L
A
N
T
N
Y
V
N
I
T
K
M
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation