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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CREB
Full Name:
Cyclic AMP-responsive element-binding protein 1
Alias:
CAMP responsive element binding protein 1; CAMP-response element binding protein; CREB1; CREB-1
Type:
Transcription protein
Mass (Da):
36688
Number AA:
341
UniProt ID:
P16220
International Prot ID:
IPI00027713
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0046983
GO:0043565
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0006468
GO:0010033
Phosida
TranscriptoNet
STRING
Kinexus Products
cAMP-response element-binding protein 1 S133 phosphosite-specific antibody AB-PN553#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN553#cyclic-AMP response element binding protein-1 (K123-R135, human) peptide - Powder PE-01ACP95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACP95#cyclic-AMP response element binding protein-1 (K123-R135, human) peptide - Powder PE-03AAF90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAF90#Cyclic AMP-responsive element-binding protein 1 (K83-R95, pS93, human) pS93 biotinylated phosphopeptide - Powder PE-03AAH95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAH95#Cyclic AMP-responsive element-binding protein 1 (K83-R95, human) pS89+pS93 biotinylated phosphopeptide - Powder PE-03AAJ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAJ95#cAMP-response element-binding protein 1 (R130-K136, human) pS133 phosphopeptide - Powder PE-04ARE90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARE90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
S
G
A
E
N
Q
Q
S
G
D
A
A
V
T
E
Site 2
S80
A
Q
P
S
V
I
Q
S
P
Q
V
Q
T
V
Q
Site 3
T85
I
Q
S
P
Q
V
Q
T
V
Q
S
S
C
K
D
Site 4
S98
K
D
L
K
R
L
F
S
G
T
Q
I
S
T
I
Site 5
T100
L
K
R
L
F
S
G
T
Q
I
S
T
I
A
E
Site 6
S103
L
F
S
G
T
Q
I
S
T
I
A
E
S
E
D
Site 7
S108
Q
I
S
T
I
A
E
S
E
D
S
Q
E
S
V
Site 8
S111
T
I
A
E
S
E
D
S
Q
E
S
V
D
S
V
Site 9
S114
E
S
E
D
S
Q
E
S
V
D
S
V
T
D
S
Site 10
S117
D
S
Q
E
S
V
D
S
V
T
D
S
Q
K
R
Site 11
T119
Q
E
S
V
D
S
V
T
D
S
Q
K
R
R
E
Site 12
S121
S
V
D
S
V
T
D
S
Q
K
R
R
E
I
L
Site 13
S129
Q
K
R
R
E
I
L
S
R
R
P
S
Y
R
K
Site 14
S133
E
I
L
S
R
R
P
S
Y
R
K
I
L
N
D
cAMP-response element-binding protein 1 S133 phosphosite-specific antibody AB-PN553#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN553#cAMP-response element-binding protein 1 (R130-K136, human) pS133 phosphopeptide - Powder PE-04ARE90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ARE90
Site 15
Y134
I
L
S
R
R
P
S
Y
R
K
I
L
N
D
L
Site 16
S142
R
K
I
L
N
D
L
S
S
D
A
P
G
V
P
Site 17
S143
K
I
L
N
D
L
S
S
D
A
P
G
V
P
R
Site 18
S156
P
R
I
E
E
E
K
S
E
E
E
T
S
A
P
Site 19
S161
E
K
S
E
E
E
T
S
A
P
A
I
T
T
V
Site 20
Y175
V
T
V
P
T
P
I
Y
Q
T
S
S
G
Q
Y
Site 21
Y182
Y
Q
T
S
S
G
Q
Y
I
A
I
T
Q
G
G
Site 22
T206
D
G
V
Q
G
L
Q
T
L
T
M
T
N
A
A
Site 23
Y224
P
G
T
T
I
L
Q
Y
A
Q
T
T
D
G
Q
Site 24
S270
A
P
G
V
V
M
A
S
S
P
A
L
P
T
Q
Site 25
S271
P
G
V
V
M
A
S
S
P
A
L
P
T
Q
P
Site 26
Y307
C
R
R
K
K
K
E
Y
V
K
C
L
E
N
R
Site 27
Y336
L
K
A
L
K
D
L
Y
C
H
K
S
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation