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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
H2AFX
Full Name:
Histone H2A.x
Alias:
H2A histone family, member X; H2A.X; H2a/x; HIST5-2AX; Histone H2A.X
Type:
DNA binding protein, helicase
Mass (Da):
15145
Number AA:
143
UniProt ID:
P16104
International Prot ID:
IPI00219037
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0000786
Uniprot
OncoNet
Molecular Function:
GO:0019899
GO:0042393
PhosphoSite+
KinaseNET
Biological Process:
GO:0000077
GO:0007569
GO:0007126
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
S
G
R
G
K
T
G
G
K
A
R
A
K
Site 2
S17
K
A
R
A
K
A
K
S
R
S
S
R
A
G
L
Site 3
S19
R
A
K
A
K
S
R
S
S
R
A
G
L
Q
F
Site 4
S20
A
K
A
K
S
R
S
S
R
A
G
L
Q
F
P
Site 5
Y40
R
L
L
R
K
G
H
Y
A
E
R
V
G
A
G
Site 6
T77
A
A
R
D
N
K
K
T
R
I
I
P
R
H
L
Site 7
T102
N
K
L
L
G
G
V
T
I
A
Q
G
G
V
L
Site 8
T121
A
V
L
L
P
K
K
T
S
A
T
V
G
P
K
Site 9
S122
V
L
L
P
K
K
T
S
A
T
V
G
P
K
A
Site 10
T124
L
P
K
K
T
S
A
T
V
G
P
K
A
P
S
Site 11
T137
P
S
G
G
K
K
A
T
Q
A
S
Q
E
Y
_
Site 12
S140
G
K
K
A
T
Q
A
S
Q
E
Y
_
_
_
_
Site 13
Y143
A
T
Q
A
S
Q
E
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation