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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EZR
Full Name:
Ezrin
Alias:
Cytovillin; cytovillin 2; EZRI; p81; VIL2; Villin 2
Type:
Cytoskeletal protein
Mass (Da):
69413
Number AA:
586
UniProt ID:
P15311
International Prot ID:
IPI00746388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005884
GO:0030863
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0050839
PhosphoSite+
KinaseNET
Biological Process:
GO:0051017
GO:0007016
GO:0007159
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
K
P
I
N
V
R
V
T
T
M
D
A
E
L
E
Site 2
T24
E
F
A
I
Q
P
N
T
T
G
K
Q
L
F
D
Site 3
Y44
I
G
L
R
E
V
W
Y
F
G
L
H
Y
V
D
Site 4
Y49
V
W
Y
F
G
L
H
Y
V
D
N
K
G
F
P
Site 5
S66
L
K
L
D
K
K
V
S
A
Q
E
V
R
K
E
Site 6
Y85
F
K
F
R
A
K
F
Y
P
E
D
V
A
E
E
Site 7
T98
E
E
L
I
Q
D
I
T
Q
K
L
F
F
L
Q
Site 8
S112
Q
V
K
E
G
I
L
S
D
E
I
Y
C
P
P
Site 9
Y116
G
I
L
S
D
E
I
Y
C
P
P
E
T
A
V
Site 10
Y137
V
Q
A
K
F
G
D
Y
N
K
E
V
H
K
S
Site 11
S144
Y
N
K
E
V
H
K
S
G
Y
L
S
S
E
R
Site 12
Y146
K
E
V
H
K
S
G
Y
L
S
S
E
R
L
I
Site 13
S148
V
H
K
S
G
Y
L
S
S
E
R
L
I
P
Q
Site 14
S149
H
K
S
G
Y
L
S
S
E
R
L
I
P
Q
R
Site 15
Y191
K
D
N
A
M
L
E
Y
L
K
I
A
Q
D
L
Site 16
Y201
I
A
Q
D
L
E
M
Y
G
I
N
Y
F
E
I
Site 17
Y205
L
E
M
Y
G
I
N
Y
F
E
I
K
N
K
K
Site 18
Y228
D
A
L
G
L
N
I
Y
E
K
D
D
K
L
T
Site 19
T235
Y
E
K
D
D
K
L
T
P
K
I
G
F
P
W
Site 20
S249
W
S
E
I
R
N
I
S
F
N
D
K
K
F
V
Site 21
Y270
K
A
P
D
F
V
F
Y
A
P
R
L
R
I
N
Site 22
Y291
C
M
G
N
H
E
L
Y
M
R
R
R
K
P
D
Site 23
T299
M
R
R
R
K
P
D
T
I
E
V
Q
Q
M
K
Site 24
T332
T
E
K
K
R
R
E
T
V
E
R
E
K
E
Q
Site 25
Y354
L
M
L
R
L
Q
D
Y
E
E
K
T
K
K
A
Site 26
S366
K
K
A
E
R
E
L
S
E
Q
I
Q
R
A
L
Site 27
S413
Q
A
V
D
Q
I
K
S
Q
E
Q
L
A
A
E
Site 28
Y424
L
A
A
E
L
A
E
Y
T
A
K
I
A
L
L
Site 29
T425
A
A
E
L
A
E
Y
T
A
K
I
A
L
L
E
Site 30
T459
A
Q
D
D
L
V
K
T
K
E
E
L
H
L
V
Site 31
T468
E
E
L
H
L
V
M
T
A
P
P
P
P
P
P
Site 32
Y478
P
P
P
P
P
P
V
Y
E
P
V
S
Y
H
V
Site 33
S482
P
P
V
Y
E
P
V
S
Y
H
V
Q
E
S
L
Site 34
Y483
P
V
Y
E
P
V
S
Y
H
V
Q
E
S
L
Q
Site 35
S488
V
S
Y
H
V
Q
E
S
L
Q
D
E
G
A
E
Site 36
Y499
E
G
A
E
P
T
G
Y
S
A
E
L
S
S
E
Site 37
S500
G
A
E
P
T
G
Y
S
A
E
L
S
S
E
G
Site 38
S504
T
G
Y
S
A
E
L
S
S
E
G
I
R
D
D
Site 39
T519
R
N
E
E
K
R
I
T
E
A
E
K
N
E
R
Site 40
T533
R
V
Q
R
Q
L
L
T
L
S
S
E
L
S
Q
Site 41
S535
Q
R
Q
L
L
T
L
S
S
E
L
S
Q
A
R
Site 42
S536
R
Q
L
L
T
L
S
S
E
L
S
Q
A
R
D
Site 43
S539
L
T
L
S
S
E
L
S
Q
A
R
D
E
N
K
Site 44
T548
A
R
D
E
N
K
R
T
H
N
D
I
I
H
N
Site 45
Y565
M
R
Q
G
R
D
K
Y
K
T
L
R
Q
I
R
Site 46
T567
Q
G
R
D
K
Y
K
T
L
R
Q
I
R
Q
G
Site 47
T576
R
Q
I
R
Q
G
N
T
K
Q
R
I
D
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation