KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HSP90B1
Full Name:
Endoplasmin
Alias:
94 kDa glucose-regulated protein; ENPL; GP96; Gp96 homolog; Heat shock protein 90 kDa beta member 1; Heat shock protein 90kDa beta (Grp94) member 1; TRA1; Tumor rejection antigen 1
Type:
Apoptosis
Mass (Da):
92469
Number AA:
803
UniProt ID:
P14625
International Prot ID:
IPI00027230
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005788
GO:0005789
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003723
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0030433
GO:0006916
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Endoplasmin pan-specific antibody AB-NN049-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN049-3#Endoplasmin pan-specific antibody AB-NN049-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN049-4
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
D
E
V
D
V
D
G
T
V
E
E
D
L
G
K
Site 2
S38
V
E
E
D
L
G
K
S
R
E
G
S
R
T
D
Site 3
S42
L
G
K
S
R
E
G
S
R
T
D
D
E
V
V
Site 4
T44
K
S
R
E
G
S
R
T
D
D
E
V
V
Q
R
Site 5
S64
Q
L
D
G
L
N
A
S
Q
I
R
E
L
R
E
Site 6
S73
I
R
E
L
R
E
K
S
E
K
F
A
F
Q
A
Site 7
S92
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
Site 8
Y94
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
Site 9
S106
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
Site 10
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Site 11
T121
K
I
R
L
I
S
L
T
D
E
N
A
L
S
G
Site 12
S127
L
T
D
E
N
A
L
S
G
N
E
E
L
T
V
Site 13
T133
L
S
G
N
E
E
L
T
V
K
I
K
C
D
K
Site 14
T148
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
Site 15
T150
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
Site 16
T165
E
L
V
K
N
L
G
T
I
A
K
S
G
T
S
Site 17
S169
N
L
G
T
I
A
K
S
G
T
S
E
F
L
N
Site 18
T179
S
E
F
L
N
K
M
T
E
A
Q
E
D
G
Q
Site 19
S187
E
A
Q
E
D
G
Q
S
T
S
E
L
I
G
Q
Site 20
S189
Q
E
D
G
Q
S
T
S
E
L
I
G
Q
F
G
Site 21
Y200
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
Site 22
S201
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
Site 23
S225
D
T
Q
H
I
W
E
S
D
S
N
E
F
S
V
Site 24
S227
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
A
Site 25
S231
E
S
D
S
N
E
F
S
V
I
A
D
P
R
G
Site 26
T240
I
A
D
P
R
G
N
T
L
G
R
G
T
T
I
Site 27
T248
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
Site 28
S256
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
Site 29
Y258
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
Site 30
T263
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Site 31
Y280
Q
F
I
N
F
P
I
Y
V
W
S
S
K
T
E
Site 32
T288
V
W
S
S
K
T
E
T
V
E
E
P
M
E
E
Site 33
S306
A
K
E
E
K
E
E
S
D
D
E
A
A
V
E
Site 34
T323
E
E
E
K
K
P
K
T
K
K
V
E
K
T
V
Site 35
S347
K
P
I
W
Q
R
P
S
K
E
V
E
E
D
E
Site 36
Y355
K
E
V
E
E
D
E
Y
K
A
F
Y
K
S
F
Site 37
Y359
E
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
Site 38
S361
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
Site 39
S366
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
Site 40
Y401
P
R
G
L
F
D
E
Y
G
S
K
K
S
D
Y
Site 41
S406
D
E
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
Site 42
Y408
Y
G
S
K
K
S
D
Y
I
K
L
Y
V
R
R
Site 43
Y412
K
S
D
Y
I
K
L
Y
V
R
R
V
F
I
T
Site 44
Y429
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
Site 45
S447
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
Site 46
T450
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
Site 47
T468
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
Site 48
Y480
K
K
I
A
D
D
K
Y
N
D
T
F
W
K
E
Site 49
S501
L
G
V
I
E
D
H
S
N
R
T
R
L
A
K
Site 50
S514
A
K
L
L
R
F
Q
S
S
H
H
P
T
D
I
Site 51
S515
K
L
L
R
F
Q
S
S
H
H
P
T
D
I
T
Site 52
T519
F
Q
S
S
H
H
P
T
D
I
T
S
L
D
Q
Site 53
Y527
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Site 54
Y539
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
Site 55
S544
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
Site 56
S551
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
Site 57
S552
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Site 58
Y563
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
Site 59
T569
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
Site 60
Y575
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
Site 61
S601
E
G
V
K
F
D
E
S
E
K
T
K
E
S
R
Site 62
T604
K
F
D
E
S
E
K
T
K
E
S
R
E
A
V
Site 63
S637
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
Site 64
S650
S
P
C
A
L
V
A
S
Q
Y
G
W
S
G
N
Site 65
Y652
C
A
L
V
A
S
Q
Y
G
W
S
G
N
M
E
Site 66
Y667
R
I
M
K
A
Q
A
Y
Q
T
G
K
D
I
S
Site 67
T675
Q
T
G
K
D
I
S
T
N
Y
Y
A
S
Q
K
Site 68
Y677
G
K
D
I
S
T
N
Y
Y
A
S
Q
K
K
T
Site 69
Y678
K
D
I
S
T
N
Y
Y
A
S
Q
K
K
T
F
Site 70
S680
I
S
T
N
Y
Y
A
S
Q
K
K
T
F
E
I
Site 71
T684
Y
Y
A
S
Q
K
K
T
F
E
I
N
P
R
H
Site 72
T709
K
E
D
E
D
D
K
T
V
L
D
L
A
V
V
Site 73
Y727
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Site 74
T732
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
Site 75
Y735
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
Site 76
S746
I
E
R
M
L
R
L
S
L
N
I
D
P
D
A
Site 77
T766
P
E
E
E
P
E
E
T
A
E
D
T
T
E
D
Site 78
T786
D
E
E
M
D
V
G
T
D
E
E
E
E
T
A
Site 79
T792
G
T
D
E
E
E
E
T
A
K
E
S
T
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation