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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRR
Full Name:
Insulin receptor-related protein
Alias:
EC 2.7.1.112; EC 2.7.10.1; INSRR; Insulin receptor-related protein precursor; IR-related receptor
Type:
Membrane, Integral plasma membrane protein
Mass (Da):
143720
Number AA:
1297
UniProt ID:
P14616
International Prot ID:
IPI00027212
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004714
PhosphoSite+
KinaseNET
Biological Process:
GO:0046777
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Insulin receptor-related protein pan-specific antibody AB-NK273-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK273-1#IRS1 (979-989) KinSub - Insulin receptor substrate 1 (K979-G989, mouse) peptide; Insulin receptor substrate - Powder PE-01ADC95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADC95#Insulin receptor-related protein (R1269-C1288, human) peptide - Powder PE-01BDJ85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDJ85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
D
T
V
E
V
C
P
S
L
D
I
R
S
E
V
Site 2
S49
L
R
Q
L
E
N
C
S
V
V
E
G
H
L
Q
Site 3
S72
G
E
D
F
R
G
L
S
F
P
R
L
T
Q
V
Site 4
S93
F
R
V
Y
G
L
E
S
L
R
D
L
F
P
N
Site 5
T194
A
G
E
P
C
A
K
T
T
F
S
G
H
T
D
Site 6
T195
G
E
P
C
A
K
T
T
F
S
G
H
T
D
Y
Site 7
Y202
T
F
S
G
H
T
D
Y
R
C
W
T
S
S
H
Site 8
S238
T
E
C
L
G
G
C
S
Q
P
E
D
P
R
A
Site 9
Y269
C
P
P
G
T
Y
Q
Y
E
S
W
R
C
V
T
Site 10
T276
Y
E
S
W
R
C
V
T
A
E
R
C
A
S
L
Site 11
S282
V
T
A
E
R
C
A
S
L
H
S
V
P
G
R
Site 12
S285
E
R
C
A
S
L
H
S
V
P
G
R
A
S
T
Site 13
S291
H
S
V
P
G
R
A
S
T
F
G
I
H
Q
G
Site 14
T292
S
V
P
G
R
A
S
T
F
G
I
H
Q
G
S
Site 15
S306
S
C
L
A
Q
C
P
S
G
F
T
R
N
S
S
Site 16
T309
A
Q
C
P
S
G
F
T
R
N
S
S
S
I
F
Site 17
S312
P
S
G
F
T
R
N
S
S
S
I
F
C
H
K
Site 18
S313
S
G
F
T
R
N
S
S
S
I
F
C
H
K
C
Site 19
T334
E
C
K
V
G
T
K
T
I
D
S
I
Q
A
A
Site 20
Y362
I
L
N
L
R
Q
G
Y
N
L
E
P
Q
L
Q
Site 21
S387
G
F
L
K
I
K
H
S
F
A
L
V
S
L
G
Site 22
Y412
D
A
M
V
D
G
N
Y
T
L
Y
V
L
D
N
Site 23
Y415
V
D
G
N
Y
T
L
Y
V
L
D
N
Q
N
L
Site 24
T460
I
Y
R
L
E
E
V
T
G
T
R
G
R
Q
N
Site 25
T462
R
L
E
E
V
T
G
T
R
G
R
Q
N
K
A
Site 26
T484
G
D
R
A
A
C
Q
T
R
T
L
R
F
V
S
Site 27
T486
R
A
A
C
Q
T
R
T
L
R
F
V
S
N
V
Site 28
S491
T
R
T
L
R
F
V
S
N
V
T
E
A
D
R
Site 29
Y520
D
L
L
S
F
I
V
Y
Y
K
E
S
P
F
Q
Site 30
T530
E
S
P
F
Q
N
A
T
E
H
V
G
P
D
A
Site 31
T540
V
G
P
D
A
C
G
T
Q
S
W
N
L
L
D
Site 32
S542
P
D
A
C
G
T
Q
S
W
N
L
L
D
V
E
Site 33
S553
L
D
V
E
L
P
L
S
R
T
Q
E
P
G
V
Site 34
T555
V
E
L
P
L
S
R
T
Q
E
P
G
V
T
L
Site 35
T561
R
T
Q
E
P
G
V
T
L
A
S
L
K
P
W
Site 36
S564
E
P
G
V
T
L
A
S
L
K
P
W
T
Q
Y
Site 37
Y571
S
L
K
P
W
T
Q
Y
A
V
F
V
R
A
I
Site 38
T581
F
V
R
A
I
T
L
T
T
E
E
D
S
P
H
Site 39
T582
V
R
A
I
T
L
T
T
E
E
D
S
P
H
Q
Site 40
S586
T
L
T
T
E
E
D
S
P
H
Q
G
A
Q
S
Site 41
S593
S
P
H
Q
G
A
Q
S
P
I
V
Y
L
R
T
Site 42
Y597
G
A
Q
S
P
I
V
Y
L
R
T
L
P
A
A
Site 43
S613
T
V
P
Q
D
V
I
S
T
S
N
S
S
S
H
Site 44
T614
V
P
Q
D
V
I
S
T
S
N
S
S
S
H
L
Site 45
S615
P
Q
D
V
I
S
T
S
N
S
S
S
H
L
L
Site 46
S617
D
V
I
S
T
S
N
S
S
S
H
L
L
V
R
Site 47
S619
I
S
T
S
N
S
S
S
H
L
L
V
R
W
K
Site 48
T629
L
V
R
W
K
P
P
T
Q
R
N
G
N
L
T
Site 49
Y637
Q
R
N
G
N
L
T
Y
Y
L
V
L
W
Q
R
Site 50
Y638
R
N
G
N
L
T
Y
Y
L
V
L
W
Q
R
L
Site 51
Y652
L
A
E
D
G
D
L
Y
L
N
D
Y
C
H
R
Site 52
Y656
G
D
L
Y
L
N
D
Y
C
H
R
G
L
R
L
Site 53
T665
H
R
G
L
R
L
P
T
S
N
N
D
P
R
F
Site 54
S666
R
G
L
R
L
P
T
S
N
N
D
P
R
F
D
Site 55
S708
P
L
E
A
Q
E
A
S
F
Q
K
K
F
E
N
Site 56
S732
I
S
P
W
K
V
T
S
I
N
K
S
P
Q
R
Site 57
S736
K
V
T
S
I
N
K
S
P
Q
R
D
S
G
R
Site 58
S741
N
K
S
P
Q
R
D
S
G
R
H
R
R
A
A
Site 59
T781
L
S
G
L
R
H
F
T
E
Y
R
I
D
I
H
Site 60
Y783
G
L
R
H
F
T
E
Y
R
I
D
I
H
A
C
Site 61
T951
Y
G
K
K
R
N
R
T
L
Y
A
S
V
N
P
Site 62
Y953
K
K
R
N
R
T
L
Y
A
S
V
N
P
E
Y
Site 63
S955
R
N
R
T
L
Y
A
S
V
N
P
E
Y
F
S
Site 64
Y960
Y
A
S
V
N
P
E
Y
F
S
A
S
D
M
Y
Site 65
S962
S
V
N
P
E
Y
F
S
A
S
D
M
Y
V
P
Site 66
S964
N
P
E
Y
F
S
A
S
D
M
Y
V
P
D
E
Site 67
Y967
Y
F
S
A
S
D
M
Y
V
P
D
E
W
E
V
Site 68
S980
E
V
P
R
E
Q
I
S
I
I
R
E
L
G
Q
Site 69
S989
I
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
Site 70
T1008
L
E
A
G
E
E
S
T
P
V
A
L
K
T
V
Site 71
S1020
K
T
V
N
E
L
A
S
P
R
E
C
I
E
F
Site 72
S1069
M
T
R
G
D
L
K
S
H
L
R
S
L
R
P
Site 73
S1073
D
L
K
S
H
L
R
S
L
R
P
E
A
E
N
Site 74
Y1105
E
I
A
D
G
M
A
Y
L
A
A
N
K
F
V
Site 75
S1124
A
A
R
N
C
M
V
S
Q
D
F
T
V
K
I
Site 76
T1128
C
M
V
S
Q
D
F
T
V
K
I
G
D
F
G
Site 77
Y1141
F
G
M
T
R
D
V
Y
E
T
D
Y
Y
R
K
Site 78
T1143
M
T
R
D
V
Y
E
T
D
Y
Y
R
K
G
G
Site 79
Y1145
R
D
V
Y
E
T
D
Y
Y
R
K
G
G
K
G
Site 80
Y1146
D
V
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
Site 81
S1163
V
R
W
M
A
P
E
S
L
K
D
G
I
F
T
Site 82
T1171
L
K
D
G
I
F
T
T
H
S
D
V
W
S
F
Site 83
Y1193
V
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
Site 84
S1197
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
Site 85
S1238
P
N
P
R
L
R
P
S
F
T
H
I
L
D
S
Site 86
T1240
P
R
L
R
P
S
F
T
H
I
L
D
S
I
Q
Site 87
S1245
S
F
T
H
I
L
D
S
I
Q
E
E
L
R
P
Site 88
S1253
I
Q
E
E
L
R
P
S
F
R
L
L
S
F
Y
Site 89
S1258
R
P
S
F
R
L
L
S
F
Y
Y
S
P
E
C
Site 90
Y1260
S
F
R
L
L
S
F
Y
Y
S
P
E
C
R
G
Site 91
S1262
R
L
L
S
F
Y
Y
S
P
E
C
R
G
A
R
Site 92
S1271
E
C
R
G
A
R
G
S
L
P
T
T
D
A
E
Site 93
T1274
G
A
R
G
S
L
P
T
T
D
A
E
P
D
S
Site 94
T1275
A
R
G
S
L
P
T
T
D
A
E
P
D
S
S
Site 95
S1281
T
T
D
A
E
P
D
S
S
P
T
P
R
D
C
Site 96
S1282
T
D
A
E
P
D
S
S
P
T
P
R
D
C
S
Site 97
T1284
A
E
P
D
S
S
P
T
P
R
D
C
S
P
Q
Site 98
S1289
S
P
T
P
R
D
C
S
P
Q
N
G
G
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation