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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HS1
Full Name:
Hematopoietic lineage cell-specific protein
Alias:
cortactin-like; CTTNL; HCLS1; Hematopoietic cell- specific LYN substrate 1; hematopoietic cell-specific Lyn substrate 1; Hematopoietic lineage cell specific protein; LCKBP1
Type:
Adapter/scaffold protein
Mass (Da):
53998
Number AA:
486
UniProt ID:
P14317
International Prot ID:
IPI00026156
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0030218
GO:0007242
GO:0008284
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
V
G
H
D
V
S
V
S
V
E
T
Q
G
D
D
Site 2
T16
D
V
S
V
S
V
E
T
Q
G
D
D
W
D
T
Site 3
T23
T
Q
G
D
D
W
D
T
D
P
D
F
V
N
D
Site 4
S32
P
D
F
V
N
D
I
S
E
K
E
Q
R
W
G
Site 5
T42
E
Q
R
W
G
A
K
T
I
E
G
S
G
R
T
Site 6
S46
G
A
K
T
I
E
G
S
G
R
T
E
H
I
N
Site 7
S75
L
R
K
K
E
M
E
S
G
P
K
A
S
H
G
Site 8
Y83
G
P
K
A
S
H
G
Y
G
G
R
F
G
V
E
Site 9
S97
E
R
D
R
M
D
K
S
A
V
G
H
E
Y
V
Site 10
Y103
K
S
A
V
G
H
E
Y
V
A
E
V
E
K
H
Site 11
S112
A
E
V
E
K
H
S
S
Q
T
D
A
A
K
G
Site 12
Y124
A
K
G
F
G
G
K
Y
G
V
E
R
D
R
A
Site 13
S134
E
R
D
R
A
D
K
S
A
V
G
F
D
Y
K
Site 14
Y140
K
S
A
V
G
F
D
Y
K
G
E
V
E
K
H
Site 15
S149
G
E
V
E
K
H
T
S
Q
K
D
Y
S
R
G
Site 16
Y153
K
H
T
S
Q
K
D
Y
S
R
G
F
G
G
R
Site 17
S154
H
T
S
Q
K
D
Y
S
R
G
F
G
G
R
Y
Site 18
Y161
S
R
G
F
G
G
R
Y
G
V
E
K
D
K
W
Site 19
Y175
W
D
K
A
A
L
G
Y
D
Y
K
G
E
T
E
Site 20
Y177
K
A
A
L
G
Y
D
Y
K
G
E
T
E
K
H
Site 21
T181
G
Y
D
Y
K
G
E
T
E
K
H
E
S
Q
R
Site 22
S186
G
E
T
E
K
H
E
S
Q
R
D
Y
A
K
G
Site 23
Y190
K
H
E
S
Q
R
D
Y
A
K
G
F
G
G
Q
Site 24
Y198
A
K
G
F
G
G
Q
Y
G
I
Q
K
D
R
V
Site 25
S208
Q
K
D
R
V
D
K
S
A
V
G
F
N
E
M
Site 26
T220
N
E
M
E
A
P
T
T
A
Y
K
K
T
T
P
Site 27
Y222
M
E
A
P
T
T
A
Y
K
K
T
T
P
I
E
Site 28
T226
T
T
A
Y
K
K
T
T
P
I
E
A
A
S
S
Site 29
S233
T
P
I
E
A
A
S
S
G
A
R
G
L
K
A
Site 30
T272
Q
Q
E
R
K
A
V
T
K
R
S
P
E
A
P
Site 31
S275
R
K
A
V
T
K
R
S
P
E
A
P
Q
P
V
Site 32
S299
A
P
L
P
K
K
I
S
S
E
A
W
P
P
V
Site 33
S300
P
L
P
K
K
I
S
S
E
A
W
P
P
V
G
Site 34
T308
E
A
W
P
P
V
G
T
P
P
S
S
E
S
E
Site 35
S311
P
P
V
G
T
P
P
S
S
E
S
E
P
V
R
Site 36
S312
P
V
G
T
P
P
S
S
E
S
E
P
V
R
T
Site 37
S314
G
T
P
P
S
S
E
S
E
P
V
R
T
S
R
Site 38
T319
S
E
S
E
P
V
R
T
S
R
E
H
P
V
P
Site 39
S320
E
S
E
P
V
R
T
S
R
E
H
P
V
P
L
Site 40
T333
P
L
L
P
I
R
Q
T
L
P
E
D
N
E
E
Site 41
T348
P
P
A
L
P
P
R
T
L
E
G
L
Q
V
E
Site 42
Y360
Q
V
E
E
E
P
V
Y
E
A
E
P
E
P
E
Site 43
Y378
E
P
E
P
E
N
D
Y
E
D
V
E
E
M
D
Site 44
Y397
E
D
E
P
E
G
D
Y
E
E
V
L
E
P
E
Site 45
S406
E
V
L
E
P
E
D
S
S
F
S
S
A
L
A
Site 46
S407
V
L
E
P
E
D
S
S
F
S
S
A
L
A
G
Site 47
S409
E
P
E
D
S
S
F
S
S
A
L
A
G
S
S
Site 48
S410
P
E
D
S
S
F
S
S
A
L
A
G
S
S
G
Site 49
Y437
G
I
S
A
V
A
V
Y
D
Y
Q
G
E
G
S
Site 50
Y439
S
A
V
A
V
Y
D
Y
Q
G
E
G
S
D
E
Site 51
S444
Y
D
Y
Q
G
E
G
S
D
E
L
S
F
D
P
Site 52
S448
G
E
G
S
D
E
L
S
F
D
P
D
D
V
I
Site 53
Y481
F
G
L
F
P
A
N
Y
V
K
L
L
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation