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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EEF2
Full Name:
Elongation factor 2
Alias:
EEF-2; EF2; EF-2; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl-tRNA translocase
Type:
Protein synthesis protein
Mass (Da):
95338
Number AA:
858
UniProt ID:
P13639
International Prot ID:
IPI00186290
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0030529
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006414
GO:0006414
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Eukaryotic elongation factor 2 T57 phosphosite-specific antibody AB-PN555#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN555#Eukaryotic elongation factor 2 (E53-R60, human) pT57 phosphopeptide - Powder PE-04AQY90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQY90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Site 2
T34
H
V
D
H
G
K
S
T
L
T
D
S
L
V
C
Site 3
S48
C
K
A
G
I
I
A
S
A
R
A
G
E
T
R
Site 4
T54
A
S
A
R
A
G
E
T
R
F
T
D
T
R
K
Site 5
T57
R
A
G
E
T
R
F
T
D
T
R
K
D
E
Q
Eukaryotic elongation factor 2 T57 phosphosite-specific antibody AB-PN555#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN555#Eukaryotic elongation factor 2 (E53-R60, human) pT57 phosphopeptide - Powder PE-04AQY90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQY90
Site 6
T59
G
E
T
R
F
T
D
T
R
K
D
E
Q
E
R
Site 7
T69
D
E
Q
E
R
C
I
T
I
K
S
T
A
I
S
Site 8
S72
E
R
C
I
T
I
K
S
T
A
I
S
L
F
Y
Site 9
T73
R
C
I
T
I
K
S
T
A
I
S
L
F
Y
E
Site 10
S76
T
I
K
S
T
A
I
S
L
F
Y
E
L
S
E
Site 11
Y79
S
T
A
I
S
L
F
Y
E
L
S
E
N
D
L
Site 12
S92
D
L
N
F
I
K
Q
S
K
D
G
A
G
F
L
Site 13
S113
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
Site 14
Y175
Q
L
E
P
E
E
L
Y
Q
T
F
Q
R
I
V
Site 15
T177
E
P
E
E
L
Y
Q
T
F
Q
R
I
V
E
N
Site 16
S190
E
N
V
N
V
I
I
S
T
Y
G
E
G
E
S
Site 17
Y192
V
N
V
I
I
S
T
Y
G
E
G
E
S
G
P
Site 18
S197
S
T
Y
G
E
G
E
S
G
P
M
G
N
I
M
Site 19
Y265
K
K
L
W
G
D
R
Y
F
D
P
A
N
G
K
Site 20
S274
D
P
A
N
G
K
F
S
K
S
A
T
S
P
E
Site 21
S276
A
N
G
K
F
S
K
S
A
T
S
P
E
G
K
Site 22
T278
G
K
F
S
K
S
A
T
S
P
E
G
K
K
L
Site 23
S279
K
F
S
K
S
A
T
S
P
E
G
K
K
L
P
Site 24
T288
E
G
K
K
L
P
R
T
F
C
Q
L
I
L
D
Site 25
S325
K
L
D
I
K
L
D
S
E
D
K
D
K
E
G
Site 26
Y367
S
P
V
T
A
Q
K
Y
R
C
E
L
L
Y
E
Site 27
Y373
K
Y
R
C
E
L
L
Y
E
G
P
P
D
D
E
Site 28
S387
E
A
A
M
G
I
K
S
C
D
P
K
G
P
L
Site 29
S399
G
P
L
M
M
Y
I
S
K
M
V
P
T
S
D
Site 30
T404
Y
I
S
K
M
V
P
T
S
D
K
G
R
F
Y
Site 31
S405
I
S
K
M
V
P
T
S
D
K
G
R
F
Y
A
Site 32
Y411
T
S
D
K
G
R
F
Y
A
F
G
R
V
F
S
Site 33
Y434
V
R
I
M
G
P
N
Y
T
P
G
K
K
E
D
Site 34
T435
R
I
M
G
P
N
Y
T
P
G
K
K
E
D
L
Site 35
Y443
P
G
K
K
E
D
L
Y
L
K
P
I
Q
R
T
Site 36
T487
V
K
T
G
T
I
T
T
F
E
H
A
H
N
M
Site 37
S500
N
M
R
V
M
K
F
S
V
S
P
V
V
R
V
Site 38
S502
R
V
M
K
F
S
V
S
P
V
V
R
V
A
V
Site 39
S530
G
L
K
R
L
A
K
S
D
P
M
V
Q
C
I
Site 40
S573
A
C
I
P
I
K
K
S
D
P
V
V
S
Y
R
Site 41
S578
K
K
S
D
P
V
V
S
Y
R
E
T
V
S
E
Site 42
Y579
K
S
D
P
V
V
S
Y
R
E
T
V
S
E
E
Site 43
T582
P
V
V
S
Y
R
E
T
V
S
E
E
S
N
V
Site 44
S587
R
E
T
V
S
E
E
S
N
V
L
C
L
S
K
Site 45
S593
E
S
N
V
L
C
L
S
K
S
P
N
K
H
N
Site 46
S595
N
V
L
C
L
S
K
S
P
N
K
H
N
R
L
Site 47
Y603
P
N
K
H
N
R
L
Y
M
K
A
R
P
F
P
Site 48
S623
D
I
D
K
G
E
V
S
A
R
Q
E
L
K
Q
Site 49
Y634
E
L
K
Q
R
A
R
Y
L
A
E
K
Y
E
W
Site 50
T657
W
C
F
G
P
D
G
T
G
P
N
I
L
T
D
Site 51
T663
G
T
G
P
N
I
L
T
D
I
T
K
G
V
Q
Site 52
T666
P
N
I
L
T
D
I
T
K
G
V
Q
Y
L
N
Site 53
T708
R
F
D
V
H
D
V
T
L
H
A
D
A
I
H
Site 54
T724
G
G
G
Q
I
I
P
T
A
R
R
C
L
Y
A
Site 55
S732
A
R
R
C
L
Y
A
S
V
L
T
A
Q
P
R
Site 56
Y760
E
Q
V
V
G
G
I
Y
G
V
L
N
R
K
R
Site 57
S774
R
G
H
V
F
E
E
S
Q
V
A
G
T
P
M
Site 58
T797
V
N
E
S
F
G
F
T
A
D
L
R
S
N
T
Site 59
S802
G
F
T
A
D
L
R
S
N
T
G
G
Q
A
F
Site 60
T804
T
A
D
L
R
S
N
T
G
G
Q
A
F
P
Q
Site 61
S828
P
G
D
P
F
D
N
S
S
R
P
S
Q
V
V
Site 62
S829
G
D
P
F
D
N
S
S
R
P
S
Q
V
V
A
Site 63
S832
F
D
N
S
S
R
P
S
Q
V
V
A
E
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation