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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CFTR
Full Name:
Cystic fibrosis transmembrane conductance regulator
Alias:
ABC35; ABCC7; ATP-binding cassette sub-family C, member 7; CAMP- dependent chloride channel; CF; CFTR/MRP; DJ760C5.1; MRP7; TNR-CFTR
Type:
Transporter; Channel, chloride
Mass (Da):
168142
Number AA:
1480
UniProt ID:
P13569
International Prot ID:
IPI00302383
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0016323
GO:0034707
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005224
GO:0030165
PhosphoSite+
KinaseNET
Biological Process:
GO:0007585
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Cystic Fibrosis Transmembrane Conductance Regulator (E656-S670, human) peptide - Powder PE-01ABQ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ABQ95#Cystic Fibrosis Transmembrane Conductance Regulator (R751-R765, human) peptide - Powder PE-01AGB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AGB95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
S
K
L
F
F
S
W
T
R
P
I
L
R
K
G
Site 2
Y28
R
P
I
L
R
K
G
Y
R
Q
R
L
E
L
S
Site 3
S35
Y
R
Q
R
L
E
L
S
D
I
Y
Q
I
P
S
Site 4
Y38
R
L
E
L
S
D
I
Y
Q
I
P
S
V
D
S
Site 5
S42
S
D
I
Y
Q
I
P
S
V
D
S
A
D
N
L
Site 6
S45
Y
Q
I
P
S
V
D
S
A
D
N
L
S
E
K
Site 7
Y109
L
G
R
I
I
A
S
Y
D
P
D
N
K
E
E
Site 8
T164
F
S
L
I
Y
K
K
T
L
K
L
S
S
R
V
Site 9
S168
Y
K
K
T
L
K
L
S
S
R
V
L
D
K
I
Site 10
S185
G
Q
L
V
S
L
L
S
N
N
L
N
K
F
D
Site 11
Y247
L
G
R
M
M
M
K
Y
R
D
Q
R
A
G
K
Site 12
S256
D
Q
R
A
G
K
I
S
E
R
L
V
I
T
S
Site 13
S263
S
E
R
L
V
I
T
S
E
M
I
E
N
I
Q
Site 14
Y275
N
I
Q
S
V
K
A
Y
C
W
E
E
A
M
E
Site 15
T291
M
I
E
N
L
R
Q
T
E
L
K
L
T
R
K
Site 16
T296
R
Q
T
E
L
K
L
T
R
K
A
A
Y
V
R
Site 17
Y301
K
L
T
R
K
A
A
Y
V
R
Y
F
N
S
S
Site 18
Y304
R
K
A
A
Y
V
R
Y
F
N
S
S
A
F
F
Site 19
Y362
P
W
A
V
Q
T
W
Y
D
S
L
G
A
I
N
Site 20
Y380
D
F
L
Q
K
Q
E
Y
K
T
L
E
Y
N
L
Site 21
T382
L
Q
K
Q
E
Y
K
T
L
E
Y
N
L
T
T
Site 22
T388
K
T
L
E
Y
N
L
T
T
T
E
V
V
M
E
Site 23
T421
Q
N
N
N
N
R
K
T
S
N
G
D
D
S
L
Site 24
S422
N
N
N
N
R
K
T
S
N
G
D
D
S
L
F
Site 25
S427
K
T
S
N
G
D
D
S
L
F
F
S
N
F
S
Site 26
S478
I
M
G
E
L
E
P
S
E
G
K
I
K
H
S
Site 27
S485
S
E
G
K
I
K
H
S
G
R
I
S
F
C
S
Site 28
S511
E
N
I
I
F
G
V
S
Y
D
E
Y
R
Y
R
Site 29
Y512
N
I
I
F
G
V
S
Y
D
E
Y
R
Y
R
S
Site 30
Y515
F
G
V
S
Y
D
E
Y
R
Y
R
S
V
I
K
Site 31
Y517
V
S
Y
D
E
Y
R
Y
R
S
V
I
K
A
C
Site 32
S531
C
Q
L
E
E
D
I
S
K
F
A
E
K
D
N
Site 33
S549
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
Site 34
S557
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
Site 35
Y569
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Site 36
T582
F
G
Y
L
D
V
L
T
E
K
E
I
F
E
S
Site 37
T599
C
K
L
M
A
N
K
T
R
I
L
V
T
S
K
Site 38
T604
N
K
T
R
I
L
V
T
S
K
M
E
H
L
K
Site 39
S605
K
T
R
I
L
V
T
S
K
M
E
H
L
K
K
Site 40
Y625
I
L
H
E
G
S
S
Y
F
Y
G
T
F
S
E
Site 41
Y627
H
E
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
Site 42
T629
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
N
L
Site 43
S641
Q
N
L
Q
P
D
F
S
S
K
L
M
G
C
D
Site 44
S649
S
K
L
M
G
C
D
S
F
D
Q
F
S
A
E
Site 45
S654
C
D
S
F
D
Q
F
S
A
E
R
R
N
S
I
Site 46
S660
F
S
A
E
R
R
N
S
I
L
T
E
T
L
H
Site 47
T663
E
R
R
N
S
I
L
T
E
T
L
H
R
F
S
Site 48
T665
R
N
S
I
L
T
E
T
L
H
R
F
S
L
E
Site 49
S670
T
E
T
L
H
R
F
S
L
E
G
D
A
P
V
Site 50
S678
L
E
G
D
A
P
V
S
W
T
E
T
K
K
Q
Site 51
T682
A
P
V
S
W
T
E
T
K
K
Q
S
F
K
Q
Site 52
S686
W
T
E
T
K
K
Q
S
F
K
Q
T
G
E
F
Site 53
T690
K
K
Q
S
F
K
Q
T
G
E
F
G
E
K
R
Site 54
S700
F
G
E
K
R
K
N
S
I
L
N
P
I
N
S
Site 55
S707
S
I
L
N
P
I
N
S
I
R
K
F
S
I
V
Site 56
S712
I
N
S
I
R
K
F
S
I
V
Q
K
T
P
L
Site 57
T717
K
F
S
I
V
Q
K
T
P
L
Q
M
N
G
I
Site 58
S728
M
N
G
I
E
E
D
S
D
E
P
L
E
R
R
Site 59
S737
E
P
L
E
R
R
L
S
L
V
P
D
S
E
Q
Site 60
S742
R
L
S
L
V
P
D
S
E
Q
G
E
A
I
L
Site 61
S753
E
A
I
L
P
R
I
S
V
I
S
T
G
P
T
Site 62
T757
P
R
I
S
V
I
S
T
G
P
T
L
Q
A
R
Site 63
T760
S
V
I
S
T
G
P
T
L
Q
A
R
R
R
Q
Site 64
S768
L
Q
A
R
R
R
Q
S
V
L
N
L
M
T
H
Site 65
T774
Q
S
V
L
N
L
M
T
H
S
V
N
Q
G
Q
Site 66
S776
V
L
N
L
M
T
H
S
V
N
Q
G
Q
N
I
Site 67
T787
G
Q
N
I
H
R
K
T
T
A
S
T
R
K
V
Site 68
T788
Q
N
I
H
R
K
T
T
A
S
T
R
K
V
S
Site 69
S790
I
H
R
K
T
T
A
S
T
R
K
V
S
L
A
Site 70
S795
T
A
S
T
R
K
V
S
L
A
P
Q
A
N
L
Site 71
T803
L
A
P
Q
A
N
L
T
E
L
D
I
Y
S
R
Site 72
Y808
N
L
T
E
L
D
I
Y
S
R
R
L
S
Q
E
Site 73
S809
L
T
E
L
D
I
Y
S
R
R
L
S
Q
E
T
Site 74
S813
D
I
Y
S
R
R
L
S
Q
E
T
G
L
E
I
Site 75
T816
S
R
R
L
S
Q
E
T
G
L
E
I
S
E
E
Site 76
Y852
T
W
N
T
Y
L
R
Y
I
T
V
H
K
S
L
Site 77
T887
V
L
W
L
L
G
N
T
P
L
Q
D
K
G
N
Site 78
T896
L
Q
D
K
G
N
S
T
H
S
R
N
N
S
Y
Site 79
S898
D
K
G
N
S
T
H
S
R
N
N
S
Y
A
V
Site 80
S902
S
T
H
S
R
N
N
S
Y
A
V
I
I
T
S
Site 81
S955
L
H
H
K
M
L
H
S
V
L
Q
A
P
M
S
Site 82
Y1014
V
V
A
V
L
Q
P
Y
I
F
V
A
T
V
P
Site 83
T1019
Q
P
Y
I
F
V
A
T
V
P
V
I
V
A
F
Site 84
S1037
R
A
Y
F
L
Q
T
S
Q
Q
L
K
Q
L
E
Site 85
S1045
Q
Q
L
K
Q
L
E
S
E
G
R
S
P
I
F
Site 86
S1049
Q
L
E
S
E
G
R
S
P
I
F
T
H
L
V
Site 87
T1053
E
G
R
S
P
I
F
T
H
L
V
T
S
L
K
Site 88
T1064
T
S
L
K
G
L
W
T
L
R
A
F
G
R
Q
Site 89
Y1073
R
A
F
G
R
Q
P
Y
F
E
T
L
F
H
K
Site 90
S1155
N
S
S
I
D
V
D
S
L
M
R
S
V
S
R
Site 91
S1159
D
V
D
S
L
M
R
S
V
S
R
V
F
K
F
Site 92
S1161
D
S
L
M
R
S
V
S
R
V
F
K
F
I
D
Site 93
T1176
M
P
T
E
G
K
P
T
K
S
T
K
P
Y
K
Site 94
S1178
T
E
G
K
P
T
K
S
T
K
P
Y
K
N
G
Site 95
Y1182
P
T
K
S
T
K
P
Y
K
N
G
Q
L
S
K
Site 96
T1211
W
P
S
G
G
Q
M
T
V
K
D
L
T
A
K
Site 97
T1216
Q
M
T
V
K
D
L
T
A
K
Y
T
E
G
G
Site 98
Y1219
V
K
D
L
T
A
K
Y
T
E
G
G
N
A
I
Site 99
S1235
E
N
I
S
F
S
I
S
P
G
Q
R
V
G
L
Site 100
S1248
G
L
L
G
R
T
G
S
G
K
S
T
L
L
S
Site 101
S1251
G
R
T
G
S
G
K
S
T
L
L
S
A
F
L
Site 102
T1252
R
T
G
S
G
K
S
T
L
L
S
A
F
L
R
Site 103
S1273
E
I
Q
I
D
G
V
S
W
D
S
I
T
L
Q
Site 104
T1278
G
V
S
W
D
S
I
T
L
Q
Q
W
R
K
A
Site 105
T1299
K
V
F
I
F
S
G
T
F
R
K
N
L
D
P
Site 106
Y1307
F
R
K
N
L
D
P
Y
E
Q
W
S
D
Q
E
Site 107
S1362
C
L
A
R
S
V
L
S
K
A
K
I
L
L
L
Site 108
T1380
S
A
H
L
D
P
V
T
Y
Q
I
I
R
R
T
Site 109
T1387
T
Y
Q
I
I
R
R
T
L
K
Q
A
F
A
D
Site 110
Y1424
E
E
N
K
V
R
Q
Y
D
S
I
Q
K
L
L
Site 111
S1426
N
K
V
R
Q
Y
D
S
I
Q
K
L
L
N
E
Site 112
S1435
Q
K
L
L
N
E
R
S
L
F
R
Q
A
I
S
Site 113
S1442
S
L
F
R
Q
A
I
S
P
S
D
R
V
K
L
Site 114
S1444
F
R
Q
A
I
S
P
S
D
R
V
K
L
F
P
Site 115
S1455
K
L
F
P
H
R
N
S
S
K
C
K
S
K
P
Site 116
S1456
L
F
P
H
R
N
S
S
K
C
K
S
K
P
Q
Site 117
S1460
R
N
S
S
K
C
K
S
K
P
Q
I
A
A
L
Site 118
T1471
I
A
A
L
K
E
E
T
E
E
E
V
Q
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation