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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NR2C1
Full Name:
Nuclear receptor subfamily 2 group C member 1
Alias:
nuclear receptor subfamily 2, group C, member 1; orphan nuclear receptor TR2; TR2; TR2-11
Type:
Receptor, nuclear
Mass (Da):
67315
Number AA:
603
UniProt ID:
P13056
International Prot ID:
IPI00334759
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003707
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
E
I
V
T
E
Q
Q
T
G
Q
K
I
Q
I
V
Site 2
T47
Q
G
K
Q
F
I
L
T
N
H
D
G
S
T
P
Site 3
T53
L
T
N
H
D
G
S
T
P
S
K
V
I
L
A
Site 4
S64
V
I
L
A
R
Q
D
S
T
P
G
K
V
F
L
Site 5
T65
I
L
A
R
Q
D
S
T
P
G
K
V
F
L
T
Site 6
T86
V
N
Q
L
F
F
T
T
P
D
L
S
A
Q
H
Site 7
S101
L
Q
L
L
T
D
N
S
P
D
Q
G
P
N
K
Site 8
S121
V
V
C
G
D
K
A
S
G
R
H
Y
G
A
V
Site 9
Y125
D
K
A
S
G
R
H
Y
G
A
V
T
C
E
G
Site 10
T129
G
R
H
Y
G
A
V
T
C
E
G
C
K
G
F
Site 11
S140
C
K
G
F
F
K
R
S
I
R
K
N
L
V
Y
Site 12
Y147
S
I
R
K
N
L
V
Y
S
C
R
G
S
K
D
Site 13
S148
I
R
K
N
L
V
Y
S
C
R
G
S
K
D
C
Site 14
S182
A
F
G
M
K
Q
D
S
V
Q
C
E
R
K
P
Site 15
S193
E
R
K
P
I
E
V
S
R
E
K
S
S
N
C
Site 16
S197
I
E
V
S
R
E
K
S
S
N
C
A
A
S
T
Site 17
S203
K
S
S
N
C
A
A
S
T
E
K
I
Y
I
R
Site 18
T204
S
S
N
C
A
A
S
T
E
K
I
Y
I
R
K
Site 19
Y208
A
A
S
T
E
K
I
Y
I
R
K
D
L
R
S
Site 20
S215
Y
I
R
K
D
L
R
S
P
L
T
A
T
P
T
Site 21
T218
K
D
L
R
S
P
L
T
A
T
P
T
F
V
T
Site 22
T220
L
R
S
P
L
T
A
T
P
T
F
V
T
D
S
Site 23
T222
S
P
L
T
A
T
P
T
F
V
T
D
S
E
S
Site 24
T225
T
A
T
P
T
F
V
T
D
S
E
S
T
R
S
Site 25
S227
T
P
T
F
V
T
D
S
E
S
T
R
S
T
G
Site 26
S229
T
F
V
T
D
S
E
S
T
R
S
T
G
L
L
Site 27
S232
T
D
S
E
S
T
R
S
T
G
L
L
D
S
G
Site 28
T233
D
S
E
S
T
R
S
T
G
L
L
D
S
G
M
Site 29
S238
R
S
T
G
L
L
D
S
G
M
F
M
N
I
H
Site 30
S247
M
F
M
N
I
H
P
S
G
V
K
T
E
S
A
Site 31
S253
P
S
G
V
K
T
E
S
A
V
L
M
T
S
D
Site 32
S259
E
S
A
V
L
M
T
S
D
K
A
E
S
C
Q
Site 33
S264
M
T
S
D
K
A
E
S
C
Q
G
D
L
S
T
Site 34
T285
S
L
A
N
L
G
K
T
K
D
L
S
Q
N
S
Site 35
S289
L
G
K
T
K
D
L
S
Q
N
S
N
E
M
S
Site 36
S292
T
K
D
L
S
Q
N
S
N
E
M
S
M
I
E
Site 37
S296
S
Q
N
S
N
E
M
S
M
I
E
S
L
S
N
Site 38
S300
N
E
M
S
M
I
E
S
L
S
N
D
D
T
S
Site 39
S302
M
S
M
I
E
S
L
S
N
D
D
T
S
L
C
Site 40
T306
E
S
L
S
N
D
D
T
S
L
C
E
F
Q
E
Site 41
S307
S
L
S
N
D
D
T
S
L
C
E
F
Q
E
M
Site 42
T326
D
V
S
R
A
F
D
T
L
A
K
A
L
N
P
Site 43
S336
K
A
L
N
P
G
E
S
T
A
C
Q
S
S
V
Site 44
T337
A
L
N
P
G
E
S
T
A
C
Q
S
S
V
A
Site 45
S341
G
E
S
T
A
C
Q
S
S
V
A
G
M
E
G
Site 46
T354
E
G
S
V
H
L
I
T
G
D
S
S
I
N
Y
Site 47
S357
V
H
L
I
T
G
D
S
S
I
N
Y
T
E
K
Site 48
S358
H
L
I
T
G
D
S
S
I
N
Y
T
E
K
E
Site 49
Y361
T
G
D
S
S
I
N
Y
T
E
K
E
G
P
L
Site 50
T362
G
D
S
S
I
N
Y
T
E
K
E
G
P
L
L
Site 51
S370
E
K
E
G
P
L
L
S
D
S
H
V
A
F
R
Site 52
S372
E
G
P
L
L
S
D
S
H
V
A
F
R
L
T
Site 53
T379
S
H
V
A
F
R
L
T
M
P
S
P
M
P
E
Site 54
S382
A
F
R
L
T
M
P
S
P
M
P
E
Y
L
N
Site 55
Y387
M
P
S
P
M
P
E
Y
L
N
V
H
Y
I
G
Site 56
Y392
P
E
Y
L
N
V
H
Y
I
G
E
S
A
S
R
Site 57
S413
H
W
A
L
S
I
P
S
F
Q
A
L
G
Q
E
Site 58
S422
Q
A
L
G
Q
E
N
S
I
S
L
V
K
A
Y
Site 59
S424
L
G
Q
E
N
S
I
S
L
V
K
A
Y
W
N
Site 60
S468
S
L
Q
Q
D
K
M
S
T
E
R
R
K
L
L
Site 61
T469
L
Q
Q
D
K
M
S
T
E
R
R
K
L
L
M
Site 62
Y497
V
K
L
C
I
D
G
Y
E
Y
A
Y
L
K
A
Site 63
S514
L
F
S
P
D
H
P
S
L
E
N
M
E
Q
I
Site 64
Y529
E
K
F
Q
E
K
A
Y
V
E
F
Q
D
Y
I
Site 65
Y535
A
Y
V
E
F
Q
D
Y
I
T
K
T
Y
P
D
Site 66
T539
F
Q
D
Y
I
T
K
T
Y
P
D
D
T
Y
R
Site 67
Y540
Q
D
Y
I
T
K
T
Y
P
D
D
T
Y
R
L
Site 68
T544
T
K
T
Y
P
D
D
T
Y
R
L
S
R
L
L
Site 69
Y545
K
T
Y
P
D
D
T
Y
R
L
S
R
L
L
L
Site 70
S548
P
D
D
T
Y
R
L
S
R
L
L
L
R
L
P
Site 71
T565
R
L
M
N
A
T
I
T
E
E
L
F
F
K
G
Site 72
S581
I
G
N
I
R
I
D
S
V
I
P
H
I
L
K
Site 73
Y594
L
K
M
E
P
A
D
Y
N
S
Q
I
I
G
H
Site 74
S596
M
E
P
A
D
Y
N
S
Q
I
I
G
H
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation