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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Ku80
Full Name:
X-ray repair cross-complementing protein 5
Alias:
86 kDa subunit of Ku antigen; ATP-dependent DNA helicase II, 80 kDa subunit; CTC box binding factor 85 kDa subunit; CTC85; CTCBF; DNA-repair protein XRCC5; double-strand-break rejoining; G22P2; KARP-1; Ku autoantigen, 80kDa; KU80; KU86; KUB2; Lupus Ku autoantigen protein p86; Nuclear factor IV; Thyroid- lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5; XRCC5
Type:
EC 3.6.1.-; DNA binding protein; Nuclear receptor co-regulator; Helicase
Mass (Da):
82573
Number AA:
731
UniProt ID:
P13010
International Prot ID:
IPI00220834
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000783
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003690
PhosphoSite+
KinaseNET
Biological Process:
GO:0006303
GO:0019059
GO:0019047
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
N
S
I
P
G
I
E
S
P
F
E
Q
A
K
K
Site 2
T39
E
Q
A
K
K
V
I
T
M
F
V
Q
R
Q
V
Site 3
T64
V
L
F
G
T
D
G
T
D
N
P
L
S
G
G
Site 4
S69
D
G
T
D
N
P
L
S
G
G
D
Q
Y
Q
N
Site 5
Y74
P
L
S
G
G
D
Q
Y
Q
N
I
T
V
H
R
Site 6
S96
D
L
L
E
D
I
E
S
K
I
Q
P
G
S
Q
Site 7
S102
E
S
K
I
Q
P
G
S
Q
Q
A
D
F
L
D
Site 8
T136
K
R
H
I
E
I
F
T
D
L
S
S
R
F
S
Site 9
S139
I
E
I
F
T
D
L
S
S
R
F
S
K
S
Q
Site 10
S140
E
I
F
T
D
L
S
S
R
F
S
K
S
Q
L
Site 11
S143
T
D
L
S
S
R
F
S
K
S
Q
L
D
I
I
Site 12
S145
L
S
S
R
F
S
K
S
Q
L
D
I
I
I
H
Site 13
S168
L
Q
F
F
L
P
F
S
L
G
K
E
D
G
S
Site 14
S175
S
L
G
K
E
D
G
S
G
D
R
G
D
G
P
Site 15
S191
R
L
G
G
H
G
P
S
F
P
L
K
G
I
T
Site 16
Y225
E
D
G
L
D
E
I
Y
S
F
S
E
S
L
R
Site 17
S226
D
G
L
D
E
I
Y
S
F
S
E
S
L
R
K
Site 18
S228
L
D
E
I
Y
S
F
S
E
S
L
R
K
L
C
Site 19
S255
P
C
R
L
T
I
G
S
N
L
S
I
R
I
A
Site 20
S258
L
T
I
G
S
N
L
S
I
R
I
A
A
Y
K
Site 21
S266
I
R
I
A
A
Y
K
S
I
L
Q
E
R
V
K
Site 22
T277
E
R
V
K
K
T
W
T
V
V
D
A
K
T
L
Site 23
T283
W
T
V
V
D
A
K
T
L
K
K
E
D
I
Q
Site 24
Y295
D
I
Q
K
E
T
V
Y
C
L
N
D
D
D
E
Site 25
T303
C
L
N
D
D
D
E
T
E
V
L
K
E
D
I
Site 26
S318
I
Q
G
F
R
Y
G
S
D
I
V
P
F
S
K
Site 27
S324
G
S
D
I
V
P
F
S
K
V
D
E
E
Q
M
Site 28
Y333
V
D
E
E
Q
M
K
Y
K
S
E
G
K
C
F
Site 29
S335
E
E
Q
M
K
Y
K
S
E
G
K
C
F
S
V
Site 30
S341
K
S
E
G
K
C
F
S
V
L
G
F
C
K
S
Site 31
S348
S
V
L
G
F
C
K
S
S
Q
V
Q
R
R
F
Site 32
S349
V
L
G
F
C
K
S
S
Q
V
Q
R
R
F
F
Site 33
Y397
V
A
I
V
R
Y
A
Y
D
K
R
A
N
P
Q
Site 34
Y416
F
P
H
I
K
H
N
Y
E
C
L
V
Y
V
Q
Site 35
Y433
F
M
E
D
L
R
Q
Y
M
F
S
S
L
K
N
Site 36
S436
D
L
R
Q
Y
M
F
S
S
L
K
N
S
K
K
Site 37
S437
L
R
Q
Y
M
F
S
S
L
K
N
S
K
K
Y
Site 38
S441
M
F
S
S
L
K
N
S
K
K
Y
A
P
T
E
Site 39
S462
D
A
L
I
D
S
M
S
L
A
K
K
D
E
K
Site 40
T470
L
A
K
K
D
E
K
T
D
T
L
E
D
L
F
Site 41
T472
K
K
D
E
K
T
D
T
L
E
D
L
F
P
T
Site 42
T480
L
E
D
L
F
P
T
T
K
I
P
N
P
R
F
Site 43
T523
L
N
P
P
A
E
V
T
T
K
S
Q
I
P
L
Site 44
T524
N
P
P
A
E
V
T
T
K
S
Q
I
P
L
S
Site 45
S526
P
A
E
V
T
T
K
S
Q
I
P
L
S
K
I
Site 46
S531
T
K
S
Q
I
P
L
S
K
I
K
T
L
F
P
Site 47
T535
I
P
L
S
K
I
K
T
L
F
P
L
I
E
A
Site 48
T563
D
N
H
E
D
G
P
T
A
K
K
L
K
T
E
Site 49
T569
P
T
A
K
K
L
K
T
E
Q
G
G
A
H
F
Site 50
S577
E
Q
G
G
A
H
F
S
V
S
S
L
A
E
G
Site 51
S579
G
G
A
H
F
S
V
S
S
L
A
E
G
S
V
Site 52
S580
G
A
H
F
S
V
S
S
L
A
E
G
S
V
T
Site 53
S591
G
S
V
T
S
V
G
S
V
N
P
A
E
N
F
Site 54
S608
L
V
K
Q
K
K
A
S
F
E
E
A
S
N
Q
Site 55
T626
H
I
E
Q
F
L
D
T
N
E
T
P
Y
F
M
Site 56
T629
Q
F
L
D
T
N
E
T
P
Y
F
M
K
S
I
Site 57
Y631
L
D
T
N
E
T
P
Y
F
M
K
S
I
D
C
Site 58
S692
L
I
T
K
E
E
A
S
G
S
S
V
T
A
E
Site 59
S694
T
K
E
E
A
S
G
S
S
V
T
A
E
E
A
Site 60
S695
K
E
E
A
S
G
S
S
V
T
A
E
E
A
K
Site 61
T715
K
D
K
P
S
G
D
T
A
A
V
F
E
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation