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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XRCC6
Full Name:
X-ray repair cross-complementing protein 6
Alias:
70 kDa subunit of Ku antigen; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; D22S671; D22S731; G22P1; Ku autoantigen, 70kDa; KU70; Lupus Ku autoantigen protein p70; ML8; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
Type:
DNA binding protein; Helicase; DNA repair
Mass (Da):
69843
Number AA:
609
UniProt ID:
P12956
International Prot ID:
IPI00644712
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005958
GO:0005624
GO:0000783
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003690
PhosphoSite+
KinaseNET
Biological Process:
GO:0006266
GO:0006303
GO:0019059
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
W
E
S
Y
Y
K
Site 2
S6
_
_
M
S
G
W
E
S
Y
Y
K
T
E
G
D
Site 3
Y7
_
_
S
G
W
E
S
Y
Y
K
T
E
G
D
E
Site 4
Y8
_
S
G
W
E
S
Y
Y
K
T
E
G
D
E
E
Site 5
T10
G
W
E
S
Y
Y
K
T
E
G
D
E
E
A
E
Site 6
S27
Q
E
E
N
L
E
A
S
G
D
Y
K
Y
S
G
Site 7
Y30
N
L
E
A
S
G
D
Y
K
Y
S
G
R
D
S
Site 8
Y32
E
A
S
G
D
Y
K
Y
S
G
R
D
S
L
I
Site 9
S33
A
S
G
D
Y
K
Y
S
G
R
D
S
L
I
F
Site 10
S37
Y
K
Y
S
G
R
D
S
L
I
F
L
V
D
A
Site 11
S51
A
S
K
A
M
F
E
S
Q
S
E
D
E
L
T
Site 12
S53
K
A
M
F
E
S
Q
S
E
D
E
L
T
P
F
Site 13
T58
S
Q
S
E
D
E
L
T
P
F
D
M
S
I
Q
Site 14
Y103
S
V
N
F
K
N
I
Y
V
L
Q
E
L
D
N
Site 15
S139
Q
D
M
M
G
H
G
S
D
Y
S
L
S
E
V
Site 16
Y141
M
M
G
H
G
S
D
Y
S
L
S
E
V
L
W
Site 17
S142
M
G
H
G
S
D
Y
S
L
S
E
V
L
W
V
Site 18
S155
W
V
C
A
N
L
F
S
D
V
Q
F
K
M
S
Site 19
T170
H
K
R
I
M
L
F
T
N
E
D
N
P
H
G
Site 20
S180
D
N
P
H
G
N
D
S
A
K
A
S
R
A
R
Site 21
S184
G
N
D
S
A
K
A
S
R
A
R
T
K
A
G
Site 22
T188
A
K
A
S
R
A
R
T
K
A
G
D
L
R
D
Site 23
S222
L
F
Y
R
D
I
I
S
I
A
E
D
E
D
L
Site 24
S237
R
V
H
F
E
E
S
S
K
L
E
D
L
L
R
Site 25
S257
E
T
R
K
R
A
L
S
R
L
K
L
K
L
N
Site 26
Y289
K
P
P
P
I
K
L
Y
R
E
T
N
E
P
V
Site 27
T292
P
I
K
L
Y
R
E
T
N
E
P
V
K
T
K
Site 28
T298
E
T
N
E
P
V
K
T
K
T
R
T
F
N
T
Site 29
T302
P
V
K
T
K
T
R
T
F
N
T
S
T
G
G
Site 30
S306
K
T
R
T
F
N
T
S
T
G
G
L
L
L
P
Site 31
T307
T
R
T
F
N
T
S
T
G
G
L
L
L
P
S
Site 32
S314
T
G
G
L
L
L
P
S
D
T
K
R
S
Q
I
Site 33
T316
G
L
L
L
P
S
D
T
K
R
S
Q
I
Y
G
Site 34
S319
L
P
S
D
T
K
R
S
Q
I
Y
G
S
R
Q
Site 35
Y322
D
T
K
R
S
Q
I
Y
G
S
R
Q
I
I
L
Site 36
S324
K
R
S
Q
I
Y
G
S
R
Q
I
I
L
E
K
Site 37
T334
I
I
L
E
K
E
E
T
E
E
L
K
R
F
D
Site 38
S365
K
H
H
Y
L
R
P
S
L
F
V
Y
P
E
E
Site 39
Y400
E
V
A
A
L
C
R
Y
T
P
R
R
N
I
P
Site 40
T401
V
A
A
L
C
R
Y
T
P
R
R
N
I
P
P
Site 41
Y409
P
R
R
N
I
P
P
Y
F
V
A
L
V
P
Q
Site 42
T428
D
D
Q
K
I
Q
V
T
P
P
G
F
Q
L
V
Site 43
T449
D
K
R
K
M
P
F
T
E
K
I
M
A
T
P
Site 44
T455
F
T
E
K
I
M
A
T
P
E
Q
V
G
K
M
Site 45
T472
I
V
E
K
L
R
F
T
Y
R
S
D
S
F
E
Site 46
Y473
V
E
K
L
R
F
T
Y
R
S
D
S
F
E
N
Site 47
S475
K
L
R
F
T
Y
R
S
D
S
F
E
N
P
V
Site 48
S477
R
F
T
Y
R
S
D
S
F
E
N
P
V
L
Q
Site 49
T507
P
E
Q
A
V
D
L
T
L
P
K
V
E
A
M
Site 50
S520
A
M
N
K
R
L
G
S
L
V
D
E
F
K
E
Site 51
Y530
D
E
F
K
E
L
V
Y
P
P
D
Y
N
P
E
Site 52
Y534
E
L
V
Y
P
P
D
Y
N
P
E
G
K
V
T
Site 53
T541
Y
N
P
E
G
K
V
T
K
R
K
H
D
N
E
Site 54
S550
R
K
H
D
N
E
G
S
G
S
K
R
P
K
V
Site 55
S552
H
D
N
E
G
S
G
S
K
R
P
K
V
E
Y
Site 56
Y559
S
K
R
P
K
V
E
Y
S
E
E
E
L
K
T
Site 57
S560
K
R
P
K
V
E
Y
S
E
E
E
L
K
T
H
Site 58
T566
Y
S
E
E
E
L
K
T
H
I
S
K
G
T
L
Site 59
S569
E
E
L
K
T
H
I
S
K
G
T
L
G
K
F
Site 60
T577
K
G
T
L
G
K
F
T
V
P
M
L
K
E
A
Site 61
Y588
L
K
E
A
C
R
A
Y
G
L
K
S
G
L
K
Site 62
S592
C
R
A
Y
G
L
K
S
G
L
K
K
Q
E
L
Site 63
T604
Q
E
L
L
E
A
L
T
K
H
F
Q
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation