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Updated November 2019
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Protein Info
Short Name:
TPR
Full Name:
Nucleoprotein TPR
Alias:
Nucleoprotein TPR; Translocated promoter region; Translocated promoter region (to activated MET oncogene)
Type:
Nucleoporin protein, actin binding protein
Mass (Da):
267293
Number AA:
2363
UniProt ID:
P12270
International Prot ID:
IPI00022970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005643
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004828
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0007094
GO:0006606
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
L
N
K
L
P
K
S
V
Q
N
K
L
E
K
Site 2
S34
K
F
L
A
D
Q
Q
S
E
I
D
G
L
K
G
Site 3
Y54
K
V
E
S
E
Q
Q
Y
F
E
I
E
K
R
L
Site 4
S62
F
E
I
E
K
R
L
S
H
S
Q
E
R
L
V
Site 5
S64
I
E
K
R
L
S
H
S
Q
E
R
L
V
N
E
Site 6
T72
Q
E
R
L
V
N
E
T
R
E
C
Q
S
L
R
Site 7
S77
N
E
T
R
E
C
Q
S
L
R
L
E
L
E
K
Site 8
S111
D
R
N
I
A
I
Q
S
Q
F
T
R
T
K
E
Site 9
T130
E
K
R
D
L
I
R
T
N
E
R
L
S
Q
E
Site 10
S135
I
R
T
N
E
R
L
S
Q
E
L
E
Y
L
T
Site 11
Y140
R
L
S
Q
E
L
E
Y
L
T
E
D
V
K
R
Site 12
T157
E
K
L
K
E
S
N
T
T
K
G
E
L
Q
L
Site 13
S172
K
L
D
E
L
Q
A
S
D
V
S
V
K
Y
R
Site 14
S175
E
L
Q
A
S
D
V
S
V
K
Y
R
E
K
R
Site 15
Y178
A
S
D
V
S
V
K
Y
R
E
K
R
L
E
Q
Site 16
S192
Q
E
K
E
L
L
H
S
Q
N
T
W
L
N
T
Site 17
T245
E
Q
M
N
G
L
K
T
S
N
E
H
L
Q
K
Site 18
T259
K
H
V
E
D
L
L
T
K
L
K
E
A
K
E
Site 19
S270
E
A
K
E
Q
Q
A
S
M
E
E
K
F
H
N
Site 20
S286
L
N
A
H
I
K
L
S
N
L
Y
K
S
A
A
Site 21
S291
K
L
S
N
L
Y
K
S
A
A
D
D
S
E
A
Site 22
S296
Y
K
S
A
A
D
D
S
E
A
K
S
N
E
L
Site 23
S300
A
D
D
S
E
A
K
S
N
E
L
T
R
A
V
Site 24
T304
E
A
K
S
N
E
L
T
R
A
V
E
E
L
H
Site 25
S334
H
L
L
E
V
E
Q
S
K
D
Q
M
E
K
E
Site 26
S361
E
N
A
N
D
L
L
S
A
T
K
R
K
G
A
Site 27
S371
K
R
K
G
A
I
L
S
E
E
E
L
A
A
M
Site 28
S379
E
E
E
L
A
A
M
S
P
T
A
A
A
V
A
Site 29
T381
E
L
A
A
M
S
P
T
A
A
A
V
A
K
I
Site 30
Y399
G
M
K
L
T
E
L
Y
N
A
Y
V
E
T
Q
Site 31
Y402
L
T
E
L
Y
N
A
Y
V
E
T
Q
D
Q
L
Site 32
Y422
E
N
K
R
I
N
K
Y
L
D
E
I
V
K
E
Site 33
Y444
L
K
R
Q
R
E
E
Y
E
R
A
Q
K
A
V
Site 34
S453
R
A
Q
K
A
V
A
S
L
S
V
K
L
E
Q
Site 35
T472
I
Q
R
L
Q
E
D
T
D
K
A
N
K
Q
S
Site 36
S480
D
K
A
N
K
Q
S
S
V
L
E
R
D
N
R
Site 37
S497
E
I
Q
V
K
D
L
S
Q
Q
I
R
V
L
L
Site 38
S522
V
I
R
D
E
E
V
S
S
A
D
I
S
S
S
Site 39
S523
I
R
D
E
E
V
S
S
A
D
I
S
S
S
S
Site 40
S527
E
V
S
S
A
D
I
S
S
S
S
E
V
I
S
Site 41
S528
V
S
S
A
D
I
S
S
S
S
E
V
I
S
Q
Site 42
S529
S
S
A
D
I
S
S
S
S
E
V
I
S
Q
H
Site 43
S530
S
A
D
I
S
S
S
S
E
V
I
S
Q
H
L
Site 44
S534
S
S
S
S
E
V
I
S
Q
H
L
V
S
Y
R
Site 45
S539
V
I
S
Q
H
L
V
S
Y
R
N
I
E
E
L
Site 46
T563
A
L
R
E
L
G
E
T
R
E
R
E
E
Q
E
Site 47
T571
R
E
R
E
E
Q
E
T
T
S
S
K
I
T
E
Site 48
T572
E
R
E
E
Q
E
T
T
S
S
K
I
T
E
L
Site 49
S574
E
E
Q
E
T
T
S
S
K
I
T
E
L
Q
L
Site 50
T588
L
K
L
E
S
A
L
T
E
L
E
Q
L
R
K
Site 51
S596
E
L
E
Q
L
R
K
S
R
Q
H
Q
M
Q
L
Site 52
Y614
I
V
R
Q
R
D
M
Y
R
I
L
L
S
Q
T
Site 53
S631
V
A
I
P
L
H
A
S
S
L
D
D
V
S
L
Site 54
S632
A
I
P
L
H
A
S
S
L
D
D
V
S
L
A
Site 55
S637
A
S
S
L
D
D
V
S
L
A
S
T
P
K
R
Site 56
S640
L
D
D
V
S
L
A
S
T
P
K
R
P
S
T
Site 57
T641
D
D
V
S
L
A
S
T
P
K
R
P
S
T
S
Site 58
S646
A
S
T
P
K
R
P
S
T
S
Q
T
V
S
T
Site 59
T647
S
T
P
K
R
P
S
T
S
Q
T
V
S
T
P
Site 60
S648
T
P
K
R
P
S
T
S
Q
T
V
S
T
P
A
Site 61
T650
K
R
P
S
T
S
Q
T
V
S
T
P
A
P
V
Site 62
S652
P
S
T
S
Q
T
V
S
T
P
A
P
V
P
V
Site 63
T653
S
T
S
Q
T
V
S
T
P
A
P
V
P
V
I
Site 64
T705
E
K
L
Q
E
Q
V
T
D
L
R
S
Q
N
T
Site 65
S709
E
Q
V
T
D
L
R
S
Q
N
T
K
I
S
T
Site 66
S722
S
T
Q
L
D
F
A
S
K
R
Y
E
M
L
Q
Site 67
Y735
L
Q
D
N
V
E
G
Y
R
R
E
I
T
S
L
Site 68
T740
E
G
Y
R
R
E
I
T
S
L
H
E
R
N
Q
Site 69
S741
G
Y
R
R
E
I
T
S
L
H
E
R
N
Q
K
Site 70
T750
H
E
R
N
Q
K
L
T
A
T
T
Q
K
Q
E
Site 71
T753
N
Q
K
L
T
A
T
T
Q
K
Q
E
Q
I
I
Site 72
T764
E
Q
I
I
N
T
M
T
Q
D
L
R
G
A
N
Site 73
S794
E
K
E
M
L
K
L
S
E
V
R
L
S
Q
Q
Site 74
S799
K
L
S
E
V
R
L
S
Q
Q
R
E
S
L
L
Site 75
S804
R
L
S
Q
Q
R
E
S
L
L
A
E
Q
R
G
Site 76
T817
R
G
Q
N
L
L
L
T
N
L
Q
T
I
Q
G
Site 77
T831
G
I
L
E
R
S
E
T
E
T
K
Q
R
L
S
Site 78
T833
L
E
R
S
E
T
E
T
K
Q
R
L
S
S
Q
Site 79
S838
T
E
T
K
Q
R
L
S
S
Q
I
E
K
L
E
Site 80
S839
E
T
K
Q
R
L
S
S
Q
I
E
K
L
E
H
Site 81
S849
E
K
L
E
H
E
I
S
H
L
K
K
K
L
E
Site 82
T864
N
E
V
E
Q
R
H
T
L
T
R
N
L
D
V
Site 83
T876
L
D
V
Q
L
L
D
T
K
R
Q
L
D
T
E
Site 84
S909
A
T
L
K
Q
H
L
S
N
M
E
V
Q
V
A
Site 85
S917
N
M
E
V
Q
V
A
S
Q
S
S
Q
R
T
G
Site 86
S919
E
V
Q
V
A
S
Q
S
S
Q
R
T
G
K
G
Site 87
S920
V
Q
V
A
S
Q
S
S
Q
R
T
G
K
G
Q
Site 88
T923
A
S
Q
S
S
Q
R
T
G
K
G
Q
P
S
N
Site 89
S939
E
D
V
D
D
L
V
S
Q
L
R
Q
T
E
E
Site 90
T944
L
V
S
Q
L
R
Q
T
E
E
Q
V
N
D
L
Site 91
T957
D
L
K
E
R
L
K
T
S
T
S
N
V
E
Q
Site 92
T959
K
E
R
L
K
T
S
T
S
N
V
E
Q
Y
Q
Site 93
S960
E
R
L
K
T
S
T
S
N
V
E
Q
Y
Q
A
Site 94
Y965
S
T
S
N
V
E
Q
Y
Q
A
M
V
T
S
L
Site 95
S971
Q
Y
Q
A
M
V
T
S
L
E
E
S
L
N
K
Site 96
S975
M
V
T
S
L
E
E
S
L
N
K
E
K
Q
V
Site 97
T983
L
N
K
E
K
Q
V
T
E
E
V
R
K
N
I
Site 98
S1028
D
K
R
R
A
I
E
S
M
E
Q
Q
L
S
E
Site 99
S1034
E
S
M
E
Q
Q
L
S
E
L
K
K
T
L
S
Site 100
T1039
Q
L
S
E
L
K
K
T
L
S
S
V
Q
N
E
Site 101
S1041
S
E
L
K
K
T
L
S
S
V
Q
N
E
V
Q
Site 102
S1055
Q
E
A
L
Q
R
A
S
T
A
L
S
N
E
Q
Site 103
T1056
E
A
L
Q
R
A
S
T
A
L
S
N
E
Q
Q
Site 104
S1059
Q
R
A
S
T
A
L
S
N
E
Q
Q
A
R
R
Site 105
Y1082
A
V
E
A
Q
N
K
Y
E
R
E
L
M
L
H
Site 106
S1104
Q
A
A
K
E
Q
V
S
K
M
A
S
V
R
Q
Site 107
S1108
E
Q
V
S
K
M
A
S
V
R
Q
H
L
E
E
Site 108
S1130
Q
L
L
E
C
K
A
S
W
E
E
R
E
R
M
Site 109
S1173
L
S
D
K
V
V
A
S
V
K
E
G
V
Q
G
Site 110
S1185
V
Q
G
P
L
N
V
S
L
S
E
E
G
K
S
Site 111
S1187
G
P
L
N
V
S
L
S
E
E
G
K
S
Q
E
Site 112
S1192
S
L
S
E
E
G
K
S
Q
E
Q
I
L
E
I
Site 113
S1221
F
E
V
A
Q
V
E
S
L
R
Y
R
Q
R
V
Site 114
Y1224
A
Q
V
E
S
L
R
Y
R
Q
R
V
E
L
L
Site 115
S1241
E
L
Q
E
L
Q
D
S
L
N
A
E
R
E
K
Site 116
T1252
E
R
E
K
V
Q
V
T
A
K
T
M
A
Q
H
Site 117
T1255
K
V
Q
V
T
A
K
T
M
A
Q
H
E
E
L
Site 118
T1268
E
L
M
K
K
T
E
T
M
N
V
V
M
E
T
Site 119
S1315
Q
E
A
N
A
E
L
S
E
K
S
G
M
L
Q
Site 120
S1344
A
R
N
Q
H
L
V
S
Q
Q
K
D
P
D
T
Site 121
T1351
S
Q
Q
K
D
P
D
T
E
E
Y
R
K
L
L
Site 122
S1359
E
E
Y
R
K
L
L
S
E
K
E
V
H
T
K
Site 123
T1372
T
K
R
I
Q
Q
L
T
E
E
I
G
R
L
K
Site 124
S1385
L
K
A
E
I
A
R
S
N
A
S
L
T
N
N
Site 125
S1388
E
I
A
R
S
N
A
S
L
T
N
N
Q
N
L
Site 126
T1390
A
R
S
N
A
S
L
T
N
N
Q
N
L
I
Q
Site 127
S1398
N
N
Q
N
L
I
Q
S
L
K
E
D
L
N
K
Site 128
T1430
D
I
Q
E
K
V
K
T
I
T
Q
V
K
K
I
Site 129
Y1441
V
K
K
I
G
R
R
Y
K
T
Q
Y
E
E
L
Site 130
T1443
K
I
G
R
R
Y
K
T
Q
Y
E
E
L
K
A
Site 131
Y1445
G
R
R
Y
K
T
Q
Y
E
E
L
K
A
Q
Q
Site 132
T1458
Q
Q
D
K
V
M
E
T
S
A
Q
S
S
G
D
Site 133
S1459
Q
D
K
V
M
E
T
S
A
Q
S
S
G
D
H
Site 134
S1462
V
M
E
T
S
A
Q
S
S
G
D
H
Q
E
Q
Site 135
S1463
M
E
T
S
A
Q
S
S
G
D
H
Q
E
Q
H
Site 136
S1472
D
H
Q
E
Q
H
V
S
V
Q
E
M
Q
E
L
Site 137
T1482
E
M
Q
E
L
K
E
T
L
N
Q
A
E
T
K
Site 138
T1488
E
T
L
N
Q
A
E
T
K
S
K
S
L
E
S
Site 139
S1490
L
N
Q
A
E
T
K
S
K
S
L
E
S
Q
V
Site 140
S1492
Q
A
E
T
K
S
K
S
L
E
S
Q
V
E
N
Site 141
S1495
T
K
S
K
S
L
E
S
Q
V
E
N
L
Q
K
Site 142
T1503
Q
V
E
N
L
Q
K
T
L
S
E
K
E
T
E
Site 143
S1505
E
N
L
Q
K
T
L
S
E
K
E
T
E
A
R
Site 144
T1509
K
T
L
S
E
K
E
T
E
A
R
N
L
Q
E
Site 145
T1518
A
R
N
L
Q
E
Q
T
V
Q
L
Q
S
E
L
Site 146
S1526
V
Q
L
Q
S
E
L
S
R
L
R
Q
D
L
Q
Site 147
T1536
R
Q
D
L
Q
D
R
T
T
Q
E
E
Q
L
R
Site 148
T1537
Q
D
L
Q
D
R
T
T
Q
E
E
Q
L
R
Q
Site 149
T1575
A
G
V
K
D
Q
L
T
K
E
N
E
E
L
K
Site 150
T1600
D
E
L
D
V
R
I
T
A
L
K
S
Q
Y
E
Site 151
S1604
V
R
I
T
A
L
K
S
Q
Y
E
G
R
I
S
Site 152
Y1606
I
T
A
L
K
S
Q
Y
E
G
R
I
S
R
L
Site 153
S1611
S
Q
Y
E
G
R
I
S
R
L
E
R
E
L
R
Site 154
T1646
P
E
Q
Q
R
Q
I
T
L
K
T
T
P
A
S
Site 155
T1649
Q
R
Q
I
T
L
K
T
T
P
A
S
G
E
R
Site 156
T1650
R
Q
I
T
L
K
T
T
P
A
S
G
E
R
G
Site 157
S1653
T
L
K
T
T
P
A
S
G
E
R
G
I
A
S
Site 158
S1660
S
G
E
R
G
I
A
S
T
S
D
P
P
T
A
Site 159
T1661
G
E
R
G
I
A
S
T
S
D
P
P
T
A
N
Site 160
S1662
E
R
G
I
A
S
T
S
D
P
P
T
A
N
I
Site 161
T1666
A
S
T
S
D
P
P
T
A
N
I
K
P
T
P
Site 162
T1672
P
T
A
N
I
K
P
T
P
V
V
S
T
P
S
Site 163
S1676
I
K
P
T
P
V
V
S
T
P
S
K
V
T
A
Site 164
T1677
K
P
T
P
V
V
S
T
P
S
K
V
T
A
A
Site 165
S1679
T
P
V
V
S
T
P
S
K
V
T
A
A
A
M
Site 166
S1691
A
A
M
A
G
N
K
S
T
P
R
A
S
I
R
Site 167
T1692
A
M
A
G
N
K
S
T
P
R
A
S
I
R
P
Site 168
S1696
N
K
S
T
P
R
A
S
I
R
P
M
V
T
P
Site 169
T1705
R
P
M
V
T
P
A
T
V
T
N
P
T
T
T
Site 170
T1712
T
V
T
N
P
T
T
T
P
T
A
T
V
M
P
Site 171
T1716
P
T
T
T
P
T
A
T
V
M
P
T
T
Q
V
Site 172
T1721
T
A
T
V
M
P
T
T
Q
V
E
S
Q
E
A
Site 173
S1731
E
S
Q
E
A
M
Q
S
E
G
P
V
E
H
V
Site 174
S1743
E
H
V
P
V
F
G
S
T
S
G
S
V
R
S
Site 175
S1745
V
P
V
F
G
S
T
S
G
S
V
R
S
T
S
Site 176
S1747
V
F
G
S
T
S
G
S
V
R
S
T
S
P
N
Site 177
S1750
S
T
S
G
S
V
R
S
T
S
P
N
V
Q
P
Site 178
T1751
T
S
G
S
V
R
S
T
S
P
N
V
Q
P
S
Site 179
S1752
S
G
S
V
R
S
T
S
P
N
V
Q
P
S
I
Site 180
S1758
T
S
P
N
V
Q
P
S
I
S
Q
P
I
L
T
Site 181
S1760
P
N
V
Q
P
S
I
S
Q
P
I
L
T
V
Q
Site 182
T1765
S
I
S
Q
P
I
L
T
V
Q
Q
Q
T
Q
A
Site 183
S1803
N
I
V
E
V
V
Q
S
S
P
V
E
R
P
S
Site 184
S1804
I
V
E
V
V
Q
S
S
P
V
E
R
P
S
T
Site 185
S1810
S
S
P
V
E
R
P
S
T
S
T
A
V
F
G
Site 186
T1811
S
P
V
E
R
P
S
T
S
T
A
V
F
G
T
Site 187
S1812
P
V
E
R
P
S
T
S
T
A
V
F
G
T
V
Site 188
T1813
V
E
R
P
S
T
S
T
A
V
F
G
T
V
S
Site 189
S1824
G
T
V
S
A
T
P
S
S
S
L
P
K
R
T
Site 190
S1825
T
V
S
A
T
P
S
S
S
L
P
K
R
T
R
Site 191
S1826
V
S
A
T
P
S
S
S
L
P
K
R
T
R
E
Site 192
S1838
T
R
E
E
E
E
D
S
T
I
E
A
S
D
Q
Site 193
T1839
R
E
E
E
E
D
S
T
I
E
A
S
D
Q
V
Site 194
S1843
E
D
S
T
I
E
A
S
D
Q
V
S
D
D
T
Site 195
S1847
I
E
A
S
D
Q
V
S
D
D
T
V
E
M
P
Site 196
T1850
S
D
Q
V
S
D
D
T
V
E
M
P
L
P
K
Site 197
S1861
P
L
P
K
K
L
K
S
V
T
P
V
G
T
E
Site 198
T1863
P
K
K
L
K
S
V
T
P
V
G
T
E
E
E
Site 199
Y1886
G
E
V
E
T
Q
V
Y
N
Q
D
S
Q
D
S
Site 200
S1890
T
Q
V
Y
N
Q
D
S
Q
D
S
I
G
E
G
Site 201
Y1903
E
G
V
T
Q
G
D
Y
T
P
M
E
D
S
E
Site 202
T1904
G
V
T
Q
G
D
Y
T
P
M
E
D
S
E
E
Site 203
S1909
D
Y
T
P
M
E
D
S
E
E
T
S
Q
S
L
Site 204
S1913
M
E
D
S
E
E
T
S
Q
S
L
Q
I
D
L
Site 205
S1915
D
S
E
E
T
S
Q
S
L
Q
I
D
L
G
P
Site 206
S1925
I
D
L
G
P
L
Q
S
D
Q
Q
T
T
T
S
Site 207
T1929
P
L
Q
S
D
Q
Q
T
T
T
S
S
Q
D
G
Site 208
S1933
D
Q
Q
T
T
T
S
S
Q
D
G
Q
G
K
G
Site 209
S1948
D
D
V
I
V
I
D
S
D
D
E
E
E
D
D
Site 210
Y1965
N
D
G
E
H
E
D
Y
E
E
D
E
E
D
D
Site 211
T1979
D
D
D
D
E
D
D
T
G
M
G
D
E
G
E
Site 212
S1988
M
G
D
E
G
E
D
S
N
E
G
T
G
S
A
Site 213
T1992
G
E
D
S
N
E
G
T
G
S
A
D
G
N
D
Site 214
S1994
D
S
N
E
G
T
G
S
A
D
G
N
D
G
Y
Site 215
Y2001
S
A
D
G
N
D
G
Y
E
A
D
D
A
E
G
Site 216
T2012
D
A
E
G
G
D
G
T
D
P
G
T
E
T
E
Site 217
T2016
G
D
G
T
D
P
G
T
E
T
E
E
S
M
G
Site 218
T2018
G
T
D
P
G
T
E
T
E
E
S
M
G
G
G
Site 219
S2021
P
G
T
E
T
E
E
S
M
G
G
G
E
G
N
Site 220
S2034
N
T
G
A
A
E
S
S
F
S
Q
E
V
S
R
Site 221
S2037
R
A
A
D
S
Q
N
S
G
E
G
N
T
G
A
Site 222
T2042
Q
N
S
G
E
G
N
T
G
A
A
E
S
S
F
Site 223
S2047
G
N
T
G
A
A
E
S
S
F
S
Q
E
V
S
Site 224
S2048
N
T
G
A
A
E
S
S
F
S
Q
E
V
S
R
Site 225
S2050
G
A
A
E
S
S
F
S
Q
E
V
S
R
E
Q
Site 226
S2054
S
S
F
S
Q
E
V
S
R
E
Q
Q
P
S
S
Site 227
S2060
V
S
R
E
Q
Q
P
S
S
A
S
E
R
Q
A
Site 228
S2061
S
R
E
Q
Q
P
S
S
A
S
E
R
Q
A
P
Site 229
S2063
E
Q
Q
P
S
S
A
S
E
R
Q
A
P
R
A
Site 230
S2073
Q
A
P
R
A
P
Q
S
P
R
R
P
P
H
P
Site 231
T2086
H
P
L
P
P
R
L
T
I
H
A
P
P
Q
E
Site 232
T2104
P
V
Q
R
I
Q
M
T
R
R
Q
S
V
G
R
Site 233
S2108
I
Q
M
T
R
R
Q
S
V
G
R
G
L
Q
L
Site 234
T2116
V
G
R
G
L
Q
L
T
P
G
I
G
G
M
Q
Site 235
T2133
F
F
D
D
E
D
R
T
V
P
S
T
P
T
L
Site 236
S2136
D
E
D
R
T
V
P
S
T
P
T
L
V
V
P
Site 237
T2137
E
D
R
T
V
P
S
T
P
T
L
V
V
P
H
Site 238
T2139
R
T
V
P
S
T
P
T
L
V
V
P
H
R
T
Site 239
T2146
T
L
V
V
P
H
R
T
D
G
F
A
E
A
I
Site 240
S2155
G
F
A
E
A
I
H
S
P
Q
V
A
G
V
P
Site 241
T2175
P
P
E
D
M
P
Q
T
S
S
S
H
S
D
L
Site 242
S2176
P
E
D
M
P
Q
T
S
S
S
H
S
D
L
G
Site 243
S2178
D
M
P
Q
T
S
S
S
H
S
D
L
G
Q
L
Site 244
S2180
P
Q
T
S
S
S
H
S
D
L
G
Q
L
A
S
Site 245
S2187
S
D
L
G
Q
L
A
S
Q
G
G
L
G
M
Y
Site 246
Y2194
S
Q
G
G
L
G
M
Y
E
T
P
L
F
L
A
Site 247
S2210
E
E
E
S
G
G
R
S
V
P
T
T
P
L
Q
Site 248
T2214
G
G
R
S
V
P
T
T
P
L
Q
V
A
A
P
Site 249
S2228
P
V
T
V
F
T
E
S
T
T
S
D
A
S
E
Site 250
S2231
V
F
T
E
S
T
T
S
D
A
S
E
H
A
S
Site 251
S2234
E
S
T
T
S
D
A
S
E
H
A
S
Q
S
V
Site 252
S2238
S
D
A
S
E
H
A
S
Q
S
V
P
M
V
T
Site 253
S2240
A
S
E
H
A
S
Q
S
V
P
M
V
T
T
S
Site 254
S2252
T
T
S
T
G
T
L
S
T
T
N
E
T
A
T
Site 255
S2276
E
A
E
S
E
G
I
S
S
E
A
G
L
E
I
Site 256
S2277
A
E
S
E
G
I
S
S
E
A
G
L
E
I
D
Site 257
S2285
E
A
G
L
E
I
D
S
Q
Q
E
E
E
P
V
Site 258
S2295
E
E
E
P
V
Q
A
S
D
E
S
D
L
P
S
Site 259
S2298
P
V
Q
A
S
D
E
S
D
L
P
S
T
S
Q
Site 260
S2302
S
D
E
S
D
L
P
S
T
S
Q
D
P
P
S
Site 261
T2303
D
E
S
D
L
P
S
T
S
Q
D
P
P
S
S
Site 262
S2304
E
S
D
L
P
S
T
S
Q
D
P
P
S
S
S
Site 263
S2309
S
T
S
Q
D
P
P
S
S
S
S
V
D
T
S
Site 264
S2310
T
S
Q
D
P
P
S
S
S
S
V
D
T
S
S
Site 265
S2311
S
Q
D
P
P
S
S
S
S
V
D
T
S
S
S
Site 266
S2312
Q
D
P
P
S
S
S
S
V
D
T
S
S
S
Q
Site 267
T2315
P
S
S
S
S
V
D
T
S
S
S
Q
P
K
P
Site 268
S2316
S
S
S
S
V
D
T
S
S
S
Q
P
K
P
F
Site 269
S2317
S
S
S
V
D
T
S
S
S
Q
P
K
P
F
R
Site 270
S2318
S
S
V
D
T
S
S
S
Q
P
K
P
F
R
R
Site 271
T2330
F
R
R
V
R
L
Q
T
T
L
R
Q
G
V
R
Site 272
T2331
R
R
V
R
L
Q
T
T
L
R
Q
G
V
R
G
Site 273
S2348
F
N
R
Q
R
G
V
S
H
A
M
G
G
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation