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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SRF
Full Name:
Serum response factor
Alias:
C-fos serum response element-binding transcription factor; MCM1; Serum response factor (C-fos serum response element-binding transcription factor) variant
Type:
Transcription protein
Mass (Da):
51593
Number AA:
508
UniProt ID:
P11831
International Prot ID:
IPI00007879
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042803
GO:0010736
GO:0003704
PhosphoSite+
KinaseNET
Biological Process:
GO:0060055
GO:0002042
GO:0001947
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
L
P
T
Q
A
G
A
A
A
A
Site 2
S16
A
A
A
L
G
R
G
S
A
L
G
G
S
L
N
Site 3
S21
R
G
S
A
L
G
G
S
L
N
R
T
P
T
G
Site 4
T25
L
G
G
S
L
N
R
T
P
T
G
R
P
G
G
Site 5
T27
G
S
L
N
R
T
P
T
G
R
P
G
G
G
G
Site 6
T71
A
A
T
T
P
A
P
T
A
G
A
L
Y
S
G
Site 7
Y76
A
P
T
A
G
A
L
Y
S
G
S
E
G
D
S
Site 8
S77
P
T
A
G
A
L
Y
S
G
S
E
G
D
S
E
Site 9
S79
A
G
A
L
Y
S
G
S
E
G
D
S
E
S
G
Site 10
S83
Y
S
G
S
E
G
D
S
E
S
G
E
E
E
E
Site 11
S85
G
S
E
G
D
S
E
S
G
E
E
E
E
L
G
Site 12
S101
E
R
R
G
L
K
R
S
L
S
E
M
E
I
G
Site 13
S103
R
G
L
K
R
S
L
S
E
M
E
I
G
M
V
Site 14
T121
P
E
A
S
A
A
A
T
G
G
Y
G
P
V
S
Site 15
S128
T
G
G
Y
G
P
V
S
G
A
V
S
G
A
K
Site 16
S132
G
P
V
S
G
A
V
S
G
A
K
P
G
K
K
Site 17
Y158
I
D
N
K
L
R
R
Y
T
T
F
S
K
R
K
Site 18
T159
D
N
K
L
R
R
Y
T
T
F
S
K
R
K
T
Site 19
T160
N
K
L
R
R
Y
T
T
F
S
K
R
K
T
G
Site 20
S162
L
R
R
Y
T
T
F
S
K
R
K
T
G
I
M
Site 21
T166
T
T
F
S
K
R
K
T
G
I
M
K
K
A
Y
Site 22
Y173
T
G
I
M
K
K
A
Y
E
L
S
T
L
T
G
Site 23
S176
M
K
K
A
Y
E
L
S
T
L
T
G
T
Q
V
Site 24
T177
K
K
A
Y
E
L
S
T
L
T
G
T
Q
V
L
Site 25
T196
S
E
T
G
H
V
Y
T
F
A
T
R
K
L
Q
Site 26
T199
G
H
V
Y
T
F
A
T
R
K
L
Q
P
M
I
Site 27
T217
T
G
K
A
L
I
Q
T
C
L
N
S
P
D
S
Site 28
S221
L
I
Q
T
C
L
N
S
P
D
S
P
P
R
S
Site 29
S224
T
C
L
N
S
P
D
S
P
P
R
S
D
P
T
Site 30
S228
S
P
D
S
P
P
R
S
D
P
T
T
D
Q
R
Site 31
T231
S
P
P
R
S
D
P
T
T
D
Q
R
M
S
A
Site 32
T232
P
P
R
S
D
P
T
T
D
Q
R
M
S
A
T
Site 33
S237
P
T
T
D
Q
R
M
S
A
T
G
F
E
E
T
Site 34
T247
G
F
E
E
T
D
L
T
Y
Q
V
S
E
S
D
Site 35
Y248
F
E
E
T
D
L
T
Y
Q
V
S
E
S
D
S
Site 36
S251
T
D
L
T
Y
Q
V
S
E
S
D
S
S
G
E
Site 37
S253
L
T
Y
Q
V
S
E
S
D
S
S
G
E
T
K
Site 38
S255
Y
Q
V
S
E
S
D
S
S
G
E
T
K
D
T
Site 39
S256
Q
V
S
E
S
D
S
S
G
E
T
K
D
T
L
Site 40
T262
S
S
G
E
T
K
D
T
L
K
P
A
F
T
V
Site 41
T268
D
T
L
K
P
A
F
T
V
T
N
L
P
G
T
Site 42
S277
T
N
L
P
G
T
T
S
T
I
Q
T
A
P
S
Site 43
T281
G
T
T
S
T
I
Q
T
A
P
S
T
S
T
T
Site 44
T288
T
A
P
S
T
S
T
T
M
Q
V
S
S
G
P
Site 45
S292
T
S
T
T
M
Q
V
S
S
G
P
S
F
P
I
Site 46
S293
S
T
T
M
Q
V
S
S
G
P
S
F
P
I
T
Site 47
S296
M
Q
V
S
S
G
P
S
F
P
I
T
N
Y
L
Site 48
S313
V
S
A
S
V
S
P
S
A
V
S
S
A
N
G
Site 49
S316
S
V
S
P
S
A
V
S
S
A
N
G
T
V
L
Site 50
T321
A
V
S
S
A
N
G
T
V
L
K
S
T
G
S
Site 51
S325
A
N
G
T
V
L
K
S
T
G
S
G
P
V
S
Site 52
S328
T
V
L
K
S
T
G
S
G
P
V
S
S
G
G
Site 53
S332
S
T
G
S
G
P
V
S
S
G
G
L
M
Q
L
Site 54
S333
T
G
S
G
P
V
S
S
G
G
L
M
Q
L
P
Site 55
S370
H
Q
A
P
Q
Q
A
S
P
S
R
D
S
S
T
Site 56
S372
A
P
Q
Q
A
S
P
S
R
D
S
S
T
D
L
Site 57
S375
Q
A
S
P
S
R
D
S
S
T
D
L
T
Q
T
Site 58
S376
A
S
P
S
R
D
S
S
T
D
L
T
Q
T
S
Site 59
T377
S
P
S
R
D
S
S
T
D
L
T
Q
T
S
S
Site 60
T380
R
D
S
S
T
D
L
T
Q
T
S
S
S
G
T
Site 61
S383
S
T
D
L
T
Q
T
S
S
S
G
T
V
T
L
Site 62
S384
T
D
L
T
Q
T
S
S
S
G
T
V
T
L
P
Site 63
T387
T
Q
T
S
S
S
G
T
V
T
L
P
A
T
I
Site 64
T401
I
M
T
S
S
V
P
T
T
V
G
G
H
M
M
Site 65
Y417
P
S
P
H
A
V
M
Y
A
P
T
S
G
L
G
Site 66
S435
L
T
V
L
N
A
F
S
Q
A
P
S
T
M
Q
Site 67
S439
N
A
F
S
Q
A
P
S
T
M
Q
V
S
H
S
Site 68
T440
A
F
S
Q
A
P
S
T
M
Q
V
S
H
S
Q
Site 69
S446
S
T
M
Q
V
S
H
S
Q
V
Q
E
P
G
G
Site 70
S487
V
I
G
Q
Q
A
G
S
S
S
N
L
T
E
L
Site 71
S504
V
N
L
D
T
A
H
S
T
K
S
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation