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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOP1
Full Name:
DNA topoisomerase 1
Alias:
DNA topoisomerase I; topoisomerase (DNA) I
Type:
EC 5.99.1.2; Isomerase
Mass (Da):
90726
Number AA:
765
UniProt ID:
P11387
International Prot ID:
IPI00413611
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005654
GO:0005694
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0003917
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
D
H
L
H
N
D
Site 2
S10
G
D
H
L
H
N
D
S
Q
I
E
A
D
F
R
Site 3
S21
A
D
F
R
L
N
D
S
H
K
H
K
D
K
H
Site 4
S47
K
E
K
D
R
E
K
S
K
H
S
N
S
E
H
Site 5
S52
E
K
S
K
H
S
N
S
E
H
K
D
S
E
K
Site 6
S57
S
N
S
E
H
K
D
S
E
K
K
H
K
E
K
Site 7
T67
K
H
K
E
K
E
K
T
K
H
K
D
G
S
S
Site 8
S73
K
T
K
H
K
D
G
S
S
E
K
H
K
D
K
Site 9
S74
T
K
H
K
D
G
S
S
E
K
H
K
D
K
H
Site 10
S97
K
E
E
K
V
R
A
S
G
D
A
K
I
K
K
Site 11
S111
K
E
K
E
N
G
F
S
S
P
P
Q
I
K
D
Site 12
S112
E
K
E
N
G
F
S
S
P
P
Q
I
K
D
E
Site 13
Y125
D
E
P
E
D
D
G
Y
F
V
P
P
K
E
D
Site 14
Y147
R
D
E
D
D
A
D
Y
K
P
K
K
I
K
T
Site 15
Y231
G
P
V
F
A
P
P
Y
E
P
L
P
E
N
V
Site 16
Y241
L
P
E
N
V
K
F
Y
Y
D
G
K
V
M
K
Site 17
Y242
P
E
N
V
K
F
Y
Y
D
G
K
V
M
K
L
Site 18
S250
D
G
K
V
M
K
L
S
P
K
A
E
E
V
A
Site 19
T258
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Site 20
Y268
A
K
M
L
D
H
E
Y
T
T
K
E
I
F
R
Site 21
T295
N
E
E
K
N
I
I
T
N
L
S
K
C
D
F
Site 22
S298
K
N
I
I
T
N
L
S
K
C
D
F
T
Q
M
Site 23
T303
N
L
S
K
C
D
F
T
Q
M
S
Q
Y
F
K
Site 24
Y308
D
F
T
Q
M
S
Q
Y
F
K
A
Q
T
E
A
Site 25
T313
S
Q
Y
F
K
A
Q
T
E
A
R
K
Q
M
S
Site 26
S320
T
E
A
R
K
Q
M
S
K
E
E
K
L
K
I
Site 27
S394
S
K
D
A
K
V
P
S
P
P
P
G
H
K
W
Site 28
Y426
N
I
Q
G
S
I
K
Y
I
M
L
N
P
S
S
Site 29
S432
K
Y
I
M
L
N
P
S
S
R
I
K
G
E
K
Site 30
S433
Y
I
M
L
N
P
S
S
R
I
K
G
E
K
D
Site 31
Y444
G
E
K
D
W
Q
K
Y
E
T
A
R
R
L
K
Site 32
T446
K
D
W
Q
K
Y
E
T
A
R
R
L
K
K
C
Site 33
Y461
V
D
K
I
R
N
Q
Y
R
E
D
W
K
S
K
Site 34
T498
N
E
K
E
E
G
E
T
A
D
T
V
G
C
C
Site 35
T501
E
E
G
E
T
A
D
T
V
G
C
C
S
L
R
Site 36
Y523
P
E
L
D
G
Q
E
Y
V
V
E
F
D
F
L
Site 37
Y537
L
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Site 38
Y538
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
K
Site 39
T570
D
L
F
D
R
L
N
T
G
I
L
N
K
H
L
Site 40
T585
Q
D
L
M
E
G
L
T
A
K
V
F
R
T
Y
Site 41
Y592
T
A
K
V
F
R
T
Y
N
A
S
I
T
L
Q
Site 42
S595
V
F
R
T
Y
N
A
S
I
T
L
Q
Q
Q
L
Site 43
T639
H
Q
R
A
P
P
K
T
F
E
K
S
M
M
N
Site 44
S643
P
P
K
T
F
E
K
S
M
M
N
L
Q
T
K
Site 45
T649
K
S
M
M
N
L
Q
T
K
I
D
A
K
K
E
Site 46
S667
D
A
R
R
D
L
K
S
A
K
A
D
A
K
V
Site 47
T680
K
V
M
K
D
A
K
T
K
K
V
V
E
S
K
Site 48
S686
K
T
K
K
V
V
E
S
K
K
K
A
V
Q
R
Site 49
T706
M
K
L
E
V
Q
A
T
D
R
E
E
N
K
Q
Site 50
Y723
L
G
T
S
K
L
N
Y
L
D
P
R
I
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation