PhosphoNET

           
Protein Info 
   
Short Name:  Pim1
Full Name:  Proto-oncogene serine/threonine-protein kinase pim-1
Alias:  EC 2.7.11.1
Type:  Protein-serine kinase, CAMK group, PIM family
Mass (Da):  45412
Number AA:  404
UniProt ID:  P11309
International Prot ID:  IPI00005014
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0030145  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0008283  GO:0007275  GO:0043066 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T10HEPHEPLTPPFSALP
Site 2S14EPLTPPFSALPDPAG
Site 3S24PDPAGAPSRRQSRQR
Site 4S28GAPSRRQSRQRPQLS
Site 5S35SRQRPQLSSDSPSAF
Site 6S36RQRPQLSSDSPSAFR
Site 7S38RPQLSSDSPSAFRAS
Site 8S40QLSSDSPSAFRASRS
Site 9S45SPSAFRASRSHSRNA
Site 10S47SAFRASRSHSRNATR
Site 11S49FRASRSHSRNATRSH
Site 12T53RSHSRNATRSHSHSH
Site 13S55HSRNATRSHSHSHSP
Site 14S57RNATRSHSHSHSPRH
Site 15S59ATRSHSHSHSPRHSL
Site 16S61RSHSHSHSPRHSLRH
Site 17S65HSHSPRHSLRHSPGS
Site 18S69PRHSLRHSPGSGSCG
Site 19S72SLRHSPGSGSCGSSS
Site 20S74RHSPGSGSCGSSSGH
Site 21S77PGSGSCGSSSGHRPC
Site 22S78GSGSCGSSSGHRPCA
Site 23S79SGSCGSSSGHRPCAD
Site 24S95LEVGMLLSKINSLAH
Site 25S99MLLSKINSLAHLRAA
Site 26S127KEKEPLESQYQVGPL
Site 27Y129KEPLESQYQVGPLLG
Site 28Y144SGGFGSVYSGIRVSD
Site 29S145GGFGSVYSGIRVSDN
Site 30S166HVEKDRISDWGELPN
Site 31T175WGELPNGTRVPMEVV
Site 32S206DWFERPDSFVLILER
Site 33T225QDLFDFITERGALQE
Site 34S237LQEELARSFFWQVLE
Site 35S280LKLIDFGSGALLKDT
Site 36T287SGALLKDTVYTDFDG
Site 37Y289ALLKDTVYTDFDGTR
Site 38T290LLKDTVYTDFDGTRV
Site 39T295VYTDFDGTRVYSPPE
Site 40Y298DFDGTRVYSPPEWIR
Site 41S299FDGTRVYSPPEWIRY
Site 42Y306SPPEWIRYHRYHGRS
Site 43Y309EWIRYHRYHGRSAAV
Site 44S351VFFRQRVSSECQHLI
Site 45S352FFRQRVSSECQHLIR
Site 46S367WCLALRPSDRPTFEE
Site 47T371LRPSDRPTFEEIQNH
Site 48S397TAEIHLHSLSPGPSK
Site 49S399EIHLHSLSPGPSK__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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