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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TFPI (Tissue Factor)
Full Name:
Tissue factor pathway inhibitor
Alias:
Extrinsic pathway inhibitor;Lipoprotein-associated coagulation inhibitor
Type:
Inhibitor protein
Mass (Da):
35015
Number AA:
304
UniProt ID:
P10646
International Prot ID:
IPI00021834
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0007598
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
P
A
P
L
N
A
D
S
E
E
D
E
E
H
T
Site 2
T42
E
H
T
I
I
T
D
T
E
L
P
P
L
K
L
Site 3
Y84
R
Q
C
E
E
F
I
Y
G
G
C
E
G
N
Q
Site 4
S96
G
N
Q
N
R
F
E
S
L
E
E
C
K
K
M
Site 5
T116
A
N
R
I
I
K
T
T
L
Q
Q
E
K
P
D
Site 6
Y137
D
P
G
I
C
R
G
Y
I
T
R
Y
F
Y
N
Site 7
Y141
C
R
G
Y
I
T
R
Y
F
Y
N
N
Q
T
K
Site 8
Y155
K
Q
C
E
R
F
K
Y
G
G
C
L
G
N
M
Site 9
Y187
N
G
F
Q
V
D
N
Y
G
T
Q
L
N
A
V
Site 10
S197
Q
L
N
A
V
N
N
S
L
T
P
Q
S
T
K
Site 11
T199
N
A
V
N
N
S
L
T
P
Q
S
T
K
V
P
Site 12
S202
N
N
S
L
T
P
Q
S
T
K
V
P
S
L
F
Site 13
T203
N
S
L
T
P
Q
S
T
K
V
P
S
L
F
E
Site 14
S207
P
Q
S
T
K
V
P
S
L
F
E
F
H
G
P
Site 15
T219
H
G
P
S
W
C
L
T
P
A
D
R
G
L
C
Site 16
Y234
R
A
N
E
N
R
F
Y
Y
N
S
V
I
G
K
Site 17
Y235
A
N
E
N
R
F
Y
Y
N
S
V
I
G
K
C
Site 18
Y247
G
K
C
R
P
F
K
Y
S
G
C
G
G
N
E
Site 19
T258
G
G
N
E
N
N
F
T
S
K
Q
E
C
L
R
Site 20
S276
K
G
F
I
Q
R
I
S
K
G
G
L
I
K
T
Site 21
T283
S
K
G
G
L
I
K
T
K
R
K
R
K
K
Q
Site 22
Y296
K
Q
R
V
K
I
A
Y
E
E
I
F
V
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation