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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DLAT
Full Name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Alias:
70 kDa mitochondrial autoantigen of primary biliary cirrhosis; Dihydrolipoamide S-acetyltransferase; DLTA; E2 component of pyruvate dehydrogenase complex; EC=2.3.1.12; PBC; PDCE2; PDC-E2; Pyruvate dehydrogenase complex E2 subunit
Type:
Transferase; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.1.12
Mass (Da):
68997
Number AA:
647
UniProt ID:
P10515
International Prot ID:
IPI00021338
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005967
Uniprot
OncoNet
Molecular Function:
GO:0004742
GO:0031405
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
A
G
L
E
A
R
W
T
A
L
Q
E
V
P
G
Site 2
T31
A
L
Q
E
V
P
G
T
P
R
V
T
S
R
S
Site 3
T35
V
P
G
T
P
R
V
T
S
R
S
G
P
A
P
Site 4
S36
P
G
T
P
R
V
T
S
R
S
G
P
A
P
A
Site 5
S38
T
P
R
V
T
S
R
S
G
P
A
P
A
R
R
Site 6
S47
P
A
P
A
R
R
N
S
V
T
T
G
Y
G
G
Site 7
T49
P
A
R
R
N
S
V
T
T
G
Y
G
G
V
R
Site 8
T50
A
R
R
N
S
V
T
T
G
Y
G
G
V
R
A
Site 9
T62
V
R
A
L
C
G
W
T
P
S
S
G
A
T
P
Site 10
S64
A
L
C
G
W
T
P
S
S
G
A
T
P
R
N
Site 11
S65
L
C
G
W
T
P
S
S
G
A
T
P
R
N
R
Site 12
T68
W
T
P
S
S
G
A
T
P
R
N
R
L
L
L
Site 13
S80
L
L
L
Q
L
L
G
S
P
G
R
R
Y
Y
S
Site 14
Y85
L
G
S
P
G
R
R
Y
Y
S
L
P
P
H
Q
Site 15
Y86
G
S
P
G
R
R
Y
Y
S
L
P
P
H
Q
K
Site 16
S87
S
P
G
R
R
Y
Y
S
L
P
P
H
Q
K
V
Site 17
S98
H
Q
K
V
P
L
P
S
L
S
P
T
M
Q
A
Site 18
S100
K
V
P
L
P
S
L
S
P
T
M
Q
A
G
T
Site 19
T102
P
L
P
S
L
S
P
T
M
Q
A
G
T
I
A
Site 20
T134
E
V
E
T
D
K
A
T
V
G
F
E
S
L
E
Site 21
S139
K
A
T
V
G
F
E
S
L
E
E
C
Y
M
A
Site 22
T154
K
I
L
V
A
E
G
T
R
D
V
P
I
G
A
Site 23
Y179
D
I
E
A
F
K
N
Y
T
L
D
S
S
A
A
Site 24
T180
I
E
A
F
K
N
Y
T
L
D
S
S
A
A
P
Site 25
S184
K
N
Y
T
L
D
S
S
A
A
P
T
P
Q
A
Site 26
T188
L
D
S
S
A
A
P
T
P
Q
A
A
P
A
P
Site 27
T196
P
Q
A
A
P
A
P
T
P
A
A
T
A
S
P
Site 28
T200
P
A
P
T
P
A
A
T
A
S
P
P
T
P
S
Site 29
S202
P
T
P
A
A
T
A
S
P
P
T
P
S
A
Q
Site 30
T205
A
A
T
A
S
P
P
T
P
S
A
Q
A
P
G
Site 31
S207
T
A
S
P
P
T
P
S
A
Q
A
P
G
S
S
Site 32
S213
P
S
A
Q
A
P
G
S
S
Y
P
P
H
M
Q
Site 33
S214
S
A
Q
A
P
G
S
S
Y
P
P
H
M
Q
V
Site 34
T231
P
A
L
S
P
T
M
T
M
G
T
V
Q
R
W
Site 35
S247
K
K
V
G
E
K
L
S
E
G
D
L
L
A
E
Site 36
Y271
F
E
V
Q
E
E
G
Y
L
A
K
I
L
V
P
Site 37
T281
K
I
L
V
P
E
G
T
R
D
V
P
L
G
T
Site 38
S301
V
E
K
E
A
D
I
S
A
F
A
D
Y
R
P
Site 39
Y306
D
I
S
A
F
A
D
Y
R
P
T
E
V
T
D
Site 40
T309
A
F
A
D
Y
R
P
T
E
V
T
D
L
K
P
Site 41
T312
D
Y
R
P
T
E
V
T
D
L
K
P
Q
V
P
Site 42
T322
K
P
Q
V
P
P
P
T
P
P
P
V
A
A
V
Site 43
T339
T
P
Q
P
L
A
P
T
P
S
A
P
C
P
A
Site 44
S341
Q
P
L
A
P
T
P
S
A
P
C
P
A
T
P
Site 45
T347
P
S
A
P
C
P
A
T
P
A
G
P
K
G
R
Site 46
S358
P
K
G
R
V
F
V
S
P
L
A
K
K
L
A
Site 47
T373
V
E
K
G
I
D
L
T
Q
V
K
G
T
G
P
Site 48
T385
T
G
P
D
G
R
I
T
K
K
D
I
D
S
F
Site 49
S391
I
T
K
K
D
I
D
S
F
V
P
S
K
V
A
Site 50
Y446
S
K
Q
T
I
P
H
Y
Y
L
S
I
D
V
N
Site 51
Y447
K
Q
T
I
P
H
Y
Y
L
S
I
D
V
N
M
Site 52
S472
N
K
I
L
E
G
R
S
K
I
S
V
N
D
F
Site 53
S475
L
E
G
R
S
K
I
S
V
N
D
F
I
I
K
Site 54
S497
K
V
P
E
A
N
S
S
W
M
D
T
V
I
R
Site 55
S543
T
I
A
N
D
V
V
S
L
A
T
K
A
R
E
Site 56
T562
P
H
E
F
Q
G
G
T
F
T
I
S
N
L
G
Site 57
Y638
W
L
A
E
F
R
K
Y
L
E
K
P
I
T
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation