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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Bcl-2
Full Name:
Apoptosis regulator Bcl-2
Alias:
B-cell CLL/lymphoma 2; BCL2
Type:
Apoptosis protein, Bcl family
Mass (Da):
26266
Number AA:
239
UniProt ID:
P10415
International Prot ID:
IPI00020961
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005741
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0051434
GO:0002020
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0042100
GO:0008633
GO:0006916
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
H
A
G
R
T
G
Y
D
N
R
E
I
V
M
Site 2
Y18
N
R
E
I
V
M
K
Y
I
H
Y
K
L
S
Q
Site 3
S24
K
Y
I
H
Y
K
L
S
Q
R
G
Y
E
W
D
Site 4
Y28
Y
K
L
S
Q
R
G
Y
E
W
D
A
G
D
V
Site 5
S50
A
P
A
P
G
I
F
S
S
Q
P
G
H
T
P
Site 6
S51
P
A
P
G
I
F
S
S
Q
P
G
H
T
P
H
Site 7
T56
F
S
S
Q
P
G
H
T
P
H
P
A
A
S
R
Site 8
S62
H
T
P
H
P
A
A
S
R
D
P
V
A
R
T
Site 9
T69
S
R
D
P
V
A
R
T
S
P
L
Q
T
P
A
Site 10
S70
R
D
P
V
A
R
T
S
P
L
Q
T
P
A
A
Site 11
T74
A
R
T
S
P
L
Q
T
P
A
A
P
G
A
A
Site 12
S87
A
A
A
G
P
A
L
S
P
V
P
P
V
V
H
Site 13
T96
V
P
P
V
V
H
L
T
L
R
Q
A
G
D
D
Site 14
S105
R
Q
A
G
D
D
F
S
R
R
Y
R
R
D
F
Site 15
Y108
G
D
D
F
S
R
R
Y
R
R
D
F
A
E
M
Site 16
S117
R
D
F
A
E
M
S
S
Q
L
H
L
T
P
F
Site 17
T122
M
S
S
Q
L
H
L
T
P
F
T
A
R
G
R
Site 18
T125
Q
L
H
L
T
P
F
T
A
R
G
R
F
A
T
Site 19
T132
T
A
R
G
R
F
A
T
V
V
E
E
L
F
R
Site 20
S161
G
G
V
M
C
V
E
S
V
N
R
E
M
S
P
Site 21
S167
E
S
V
N
R
E
M
S
P
L
V
D
N
I
A
Site 22
Y180
I
A
L
W
M
T
E
Y
L
N
R
H
L
H
T
Site 23
Y235
A
C
I
T
L
G
A
Y
L
G
H
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation