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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARP1
Full Name:
Poly [ADP-ribose] polymerase 1
Alias:
ADP-ribosyltransferase 1; ADPRT; ADPRT1; PADPRT-1; PARP; PARP-1; Poly (ADP-ribose) pol; Poly (ADP-ribose) polymerase 1; Poly[ADP-ribose] synthetase 1; PPOL
Type:
Nuclear receptor co-regulator; DNA repair; EC 2.4.2.30; Nuclear envelope; Transferase
Mass (Da):
113084
Number AA:
1014
UniProt ID:
P09874
International Prot ID:
IPI00449049
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005635
GO:0005730
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0051287
GO:0003950
PhosphoSite+
KinaseNET
Biological Process:
GO:0032869
GO:0006471
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
E
S
S
D
K
L
Y
R
V
E
Site 2
Y9
A
E
S
S
D
K
L
Y
R
V
E
Y
A
K
S
Site 3
Y13
D
K
L
Y
R
V
E
Y
A
K
S
G
R
A
S
Site 4
S16
Y
R
V
E
Y
A
K
S
G
R
A
S
C
K
K
Site 5
S20
Y
A
K
S
G
R
A
S
C
K
K
C
S
E
S
Site 6
S25
R
A
S
C
K
K
C
S
E
S
I
P
K
D
S
Site 7
S27
S
C
K
K
C
S
E
S
I
P
K
D
S
L
R
Site 8
S32
S
E
S
I
P
K
D
S
L
R
M
A
I
M
V
Site 9
S41
R
M
A
I
M
V
Q
S
P
M
F
D
G
K
V
Site 10
S75
D
V
E
V
D
G
F
S
E
L
R
W
D
D
Q
Site 11
S104
K
G
Q
D
G
I
G
S
K
A
E
K
T
L
G
Site 12
T109
I
G
S
K
A
E
K
T
L
G
D
F
A
A
E
Site 13
Y117
L
G
D
F
A
A
E
Y
A
K
S
N
R
S
T
Site 14
S120
F
A
A
E
Y
A
K
S
N
R
S
T
C
K
G
Site 15
T124
Y
A
K
S
N
R
S
T
C
K
G
C
M
E
K
Site 16
S140
E
K
G
Q
V
R
L
S
K
K
M
V
D
P
E
Site 17
Y176
E
L
G
F
R
P
E
Y
S
A
S
Q
L
K
G
Site 18
S177
L
G
F
R
P
E
Y
S
A
S
Q
L
K
G
F
Site 19
S179
F
R
P
E
Y
S
A
S
Q
L
K
G
F
S
L
Site 20
T189
K
G
F
S
L
L
A
T
E
D
K
E
A
L
K
Site 21
S204
K
Q
L
P
G
V
K
S
E
G
K
R
K
G
D
Site 22
S224
D
E
V
A
K
K
K
S
K
K
E
K
D
K
D
Site 23
S232
K
K
E
K
D
K
D
S
K
L
E
K
A
L
K
Site 24
S257
D
E
L
K
K
V
C
S
T
N
D
L
K
E
L
Site 25
S274
F
N
K
Q
Q
V
P
S
G
E
S
A
I
L
D
Site 26
S306
S
G
Q
L
V
F
K
S
D
A
Y
Y
C
T
G
Site 27
Y310
V
F
K
S
D
A
Y
Y
C
T
G
D
V
T
A
Site 28
T325
W
T
K
C
M
V
K
T
Q
T
P
N
R
K
E
Site 29
T327
K
C
M
V
K
T
Q
T
P
N
R
K
E
W
V
Site 30
T335
P
N
R
K
E
W
V
T
P
K
E
F
R
E
I
Site 31
S343
P
K
E
F
R
E
I
S
Y
L
K
K
L
K
V
Site 32
S364
F
P
P
E
T
S
A
S
V
A
A
T
P
P
P
Site 33
T368
T
S
A
S
V
A
A
T
P
P
P
S
T
A
S
Site 34
S372
V
A
A
T
P
P
P
S
T
A
S
A
P
A
A
Site 35
T373
A
A
T
P
P
P
S
T
A
S
A
P
A
A
V
Site 36
S382
S
A
P
A
A
V
N
S
S
A
S
A
D
K
P
Site 37
S385
A
A
V
N
S
S
A
S
A
D
K
P
L
S
N
Site 38
T397
L
S
N
M
K
I
L
T
L
G
K
L
S
R
N
Site 39
S427
T
G
T
A
N
K
A
S
L
C
I
S
T
K
K
Site 40
S431
N
K
A
S
L
C
I
S
T
K
K
E
V
E
K
Site 41
S455
E
A
N
I
R
V
V
S
E
D
F
L
Q
D
V
Site 42
S463
E
D
F
L
Q
D
V
S
A
S
T
K
S
L
Q
Site 43
S465
F
L
Q
D
V
S
A
S
T
K
S
L
Q
E
L
Site 44
S499
V
V
A
P
R
G
K
S
G
A
A
L
S
K
K
Site 45
S504
G
K
S
G
A
A
L
S
K
K
S
K
G
Q
V
Site 46
S519
K
E
E
G
I
N
K
S
E
K
R
M
K
L
T
Site 47
S537
G
A
A
V
D
P
D
S
G
L
E
H
S
A
H
Site 48
S568
D
I
V
K
G
T
N
S
Y
Y
K
L
Q
L
L
Site 49
Y570
V
K
G
T
N
S
Y
Y
K
L
Q
L
L
E
D
Site 50
Y583
E
D
D
K
E
N
R
Y
W
I
F
R
S
W
G
Site 51
T594
R
S
W
G
R
V
G
T
V
I
G
S
N
K
L
Site 52
S606
N
K
L
E
Q
M
P
S
K
E
D
A
I
E
H
Site 53
Y618
I
E
H
F
M
K
L
Y
E
E
K
T
G
N
A
Site 54
T622
M
K
L
Y
E
E
K
T
G
N
A
W
H
S
K
Site 55
Y634
H
S
K
N
F
T
K
Y
P
K
K
F
Y
P
L
Site 56
Y639
T
K
Y
P
K
K
F
Y
P
L
E
I
D
Y
G
Site 57
Y645
F
Y
P
L
E
I
D
Y
G
Q
D
E
E
A
V
Site 58
T656
E
E
A
V
K
K
L
T
V
N
P
G
T
K
S
Site 59
T661
K
L
T
V
N
P
G
T
K
S
K
L
P
K
P
Site 60
S663
T
V
N
P
G
T
K
S
K
L
P
K
P
V
Q
Site 61
S681
K
M
I
F
D
V
E
S
M
K
K
A
M
V
E
Site 62
S702
K
M
P
L
G
K
L
S
K
R
Q
I
Q
A
A
Site 63
S721
S
E
V
Q
Q
A
V
S
Q
G
S
S
D
S
Q
Site 64
S725
Q
A
V
S
Q
G
S
S
D
S
Q
I
L
D
L
Site 65
S727
V
S
Q
G
S
S
D
S
Q
I
L
D
L
S
N
Site 66
S733
D
S
Q
I
L
D
L
S
N
R
F
Y
T
L
I
Site 67
Y737
L
D
L
S
N
R
F
Y
T
L
I
P
H
D
F
Site 68
T738
D
L
S
N
R
F
Y
T
L
I
P
H
D
F
G
Site 69
S757
P
L
L
N
N
A
D
S
V
Q
A
K
V
E
M
Site 70
Y775
L
L
D
I
E
V
A
Y
S
L
L
R
G
G
S
Site 71
S782
Y
S
L
L
R
G
G
S
D
D
S
S
K
D
P
Site 72
S785
L
R
G
G
S
D
D
S
S
K
D
P
I
D
V
Site 73
S786
R
G
G
S
D
D
S
S
K
D
P
I
D
V
N
Site 74
Y794
K
D
P
I
D
V
N
Y
E
K
L
K
T
D
I
Site 75
T799
V
N
Y
E
K
L
K
T
D
I
K
V
V
D
R
Site 76
S808
I
K
V
V
D
R
D
S
E
E
A
E
I
I
R
Site 77
Y817
E
A
E
I
I
R
K
Y
V
K
N
T
H
A
T
Site 78
T824
Y
V
K
N
T
H
A
T
T
H
N
A
Y
D
L
Site 79
Y848
R
E
G
E
C
Q
R
Y
K
P
F
K
Q
L
H
Site 80
S864
R
R
L
L
W
H
G
S
R
T
T
N
F
A
G
Site 81
T867
L
W
H
G
S
R
T
T
N
F
A
G
I
L
S
Site 82
T887
A
P
P
E
A
P
V
T
G
Y
M
F
G
K
G
Site 83
Y889
P
E
A
P
V
T
G
Y
M
F
G
K
G
I
Y
Site 84
S911
S
A
N
Y
C
H
T
S
Q
G
D
P
I
G
L
Site 85
S939
L
K
H
A
S
H
I
S
K
L
P
K
G
K
H
Site 86
S947
K
L
P
K
G
K
H
S
V
K
G
L
G
K
T
Site 87
T954
S
V
K
G
L
G
K
T
T
P
D
P
S
A
N
Site 88
T955
V
K
G
L
G
K
T
T
P
D
P
S
A
N
I
Site 89
S959
G
K
T
T
P
D
P
S
A
N
I
S
L
D
G
Site 90
S963
P
D
P
S
A
N
I
S
L
D
G
V
D
V
P
Site 91
S983
S
S
G
V
N
D
T
S
L
L
Y
N
E
Y
I
Site 92
Y986
V
N
D
T
S
L
L
Y
N
E
Y
I
V
Y
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation