KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Pleckstrin
Full Name:
Pleckstrin
Alias:
P47; platelet p47 protein; PLEK
Type:
Lipid binding protein
Mass (Da):
40097
Number AA:
350
UniProt ID:
P08567
International Prot ID:
IPI00306311
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005576
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0043325
GO:0042803
GO:0005080
PhosphoSite+
KinaseNET
Biological Process:
GO:0031532
GO:0030866
GO:0002244
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
P
K
R
I
R
E
G
Y
L
V
K
K
G
S
V
Site 2
S16
G
Y
L
V
K
K
G
S
V
F
N
T
W
K
P
Site 3
Y36
L
E
D
G
I
E
F
Y
K
K
K
S
D
N
S
Site 4
S40
I
E
F
Y
K
K
K
S
D
N
S
P
K
G
M
Site 5
S43
Y
K
K
K
S
D
N
S
P
K
G
M
I
P
L
Site 6
S53
G
M
I
P
L
K
G
S
T
L
T
S
P
C
Q
Site 7
S57
L
K
G
S
T
L
T
S
P
C
Q
D
F
G
K
Site 8
S113
G
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
Site 9
T114
Q
K
F
A
R
K
S
T
R
R
S
I
R
L
P
Site 10
S117
A
R
K
S
T
R
R
S
I
R
L
P
E
T
I
Site 11
T123
R
S
I
R
L
P
E
T
I
D
L
G
A
L
Y
Site 12
Y130
T
I
D
L
G
A
L
Y
L
S
M
K
D
T
E
Site 13
S132
D
L
G
A
L
Y
L
S
M
K
D
T
E
K
G
Site 14
T136
L
Y
L
S
M
K
D
T
E
K
G
I
K
E
L
Site 15
S170
D
W
L
V
S
N
Q
S
V
R
N
R
Q
E
G
Site 16
S182
Q
E
G
L
M
I
A
S
S
L
L
N
E
G
Y
Site 17
Y189
S
S
L
L
N
E
G
Y
L
Q
P
A
G
D
M
Site 18
S197
L
Q
P
A
G
D
M
S
K
S
A
V
D
G
T
Site 19
S199
P
A
G
D
M
S
K
S
A
V
D
G
T
A
E
Site 20
Y217
L
D
N
P
D
A
F
Y
Y
F
P
D
S
G
F
Site 21
Y218
D
N
P
D
A
F
Y
Y
F
P
D
S
G
F
F
Site 22
S231
F
F
C
E
E
N
S
S
D
D
D
V
I
L
K
Site 23
Y274
I
L
R
E
D
P
A
Y
L
H
Y
Y
D
P
A
Site 24
Y277
E
D
P
A
Y
L
H
Y
Y
D
P
A
G
A
E
Site 25
Y278
D
P
A
Y
L
H
Y
Y
D
P
A
G
A
E
D
Site 26
T298
H
L
R
G
C
V
V
T
S
V
E
S
N
S
N
Site 27
S299
L
R
G
C
V
V
T
S
V
E
S
N
S
N
G
Site 28
S304
V
T
S
V
E
S
N
S
N
G
R
K
S
E
E
Site 29
S309
S
N
S
N
G
R
K
S
E
E
E
N
L
F
E
Site 30
T331
H
Y
F
L
Q
A
A
T
P
K
E
R
T
E
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation