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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDHA1
Full Name:
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Alias:
EC 1.2.4.1; ODPA; PDH1; PDHA; PDHA-1; PDHE1-A type I; PHE1A; Pyruvate dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor
Type:
Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.2.4.1; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - butanoate; Oxidoreductase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis
Mass (Da):
43296
Number AA:
390
UniProt ID:
P08559
International Prot ID:
IPI00306301
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004739
PhosphoSite+
KinaseNET
Biological Process:
GO:0006096
GO:0055114
GO:0006090
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
S
R
V
L
S
G
A
S
Q
K
P
A
S
R
V
Site 2
S21
G
A
S
Q
K
P
A
S
R
V
L
V
A
S
R
Site 3
S27
A
S
R
V
L
V
A
S
R
N
F
A
N
D
A
Site 4
T35
R
N
F
A
N
D
A
T
F
E
I
K
K
C
D
Site 5
T57
P
P
V
T
T
V
L
T
R
E
D
G
L
K
Y
Site 6
Y64
T
R
E
D
G
L
K
Y
Y
R
M
M
Q
T
V
Site 7
Y65
R
E
D
G
L
K
Y
Y
R
M
M
Q
T
V
R
Site 8
Y82
E
L
K
A
D
Q
L
Y
K
Q
K
I
I
R
G
Site 9
Y118
T
D
H
L
I
T
A
Y
R
A
H
G
F
T
F
Site 10
T124
A
Y
R
A
H
G
F
T
F
T
R
G
L
S
V
Site 11
T139
R
E
I
L
A
E
L
T
G
R
K
G
G
C
A
Site 12
Y156
K
G
G
S
M
H
M
Y
A
K
N
F
Y
G
G
Site 13
T192
G
K
D
E
V
C
L
T
L
Y
G
D
G
A
A
Site 14
Y194
D
E
V
C
L
T
L
Y
G
D
G
A
A
N
Q
Site 15
Y208
Q
G
Q
I
F
E
A
Y
N
M
A
A
L
W
K
Site 16
Y227
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Site 17
T231
N
N
R
Y
G
M
G
T
S
V
E
R
A
A
A
Site 18
S232
N
R
Y
G
M
G
T
S
V
E
R
A
A
A
S
Site 19
T240
V
E
R
A
A
A
S
T
D
Y
Y
K
R
G
D
Site 20
Y242
R
A
A
A
S
T
D
Y
Y
K
R
G
D
F
I
Site 21
Y243
A
A
A
S
T
D
Y
Y
K
R
G
D
F
I
P
Site 22
Y272
A
T
R
F
A
A
A
Y
C
R
S
G
K
G
P
Site 23
Y287
I
L
M
E
L
Q
T
Y
R
Y
H
G
H
S
M
Site 24
Y289
M
E
L
Q
T
Y
R
Y
H
G
H
S
M
S
D
Site 25
S293
T
Y
R
Y
H
G
H
S
M
S
D
P
G
V
S
Site 26
S295
R
Y
H
G
H
S
M
S
D
P
G
V
S
Y
R
Site 27
S300
S
M
S
D
P
G
V
S
Y
R
T
R
E
E
I
Site 28
Y301
M
S
D
P
G
V
S
Y
R
T
R
E
E
I
Q
Site 29
T303
D
P
G
V
S
Y
R
T
R
E
E
I
Q
E
V
Site 30
S312
E
E
I
Q
E
V
R
S
K
S
D
P
I
M
L
Site 31
S314
I
Q
E
V
R
S
K
S
D
P
I
M
L
L
K
Site 32
S327
L
K
D
R
M
V
N
S
N
L
A
S
V
E
E
Site 33
S331
M
V
N
S
N
L
A
S
V
E
E
L
K
E
I
Site 34
T354
E
D
A
A
Q
F
A
T
A
D
P
E
P
P
L
Site 35
Y366
P
P
L
E
E
L
G
Y
H
I
Y
S
S
D
P
Site 36
Y369
E
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
Site 37
S370
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
V
Site 38
S371
L
G
Y
H
I
Y
S
S
D
P
P
F
E
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation