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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TUBB
Full Name:
Tubulin beta chain
Alias:
M40; MGC16435; OK/SW-cl.56; TBB2; TBB5; TUBB5; Tubulin B1; Tubulin B5; Tubulin beta-5 chain; Tubulin, beta; Tubulin, beta-1
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
49671
Number AA:
444
UniProt ID:
P07437
International Prot ID:
IPI00011654
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0042288
PhosphoSite+
KinaseNET
Biological Process:
GO:0006928
GO:0007018
GO:0042267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
Site 2
T33
D
E
H
G
I
D
P
T
G
T
Y
H
G
D
S
Site 3
T35
H
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Site 4
Y36
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Q
Site 5
S40
T
G
T
Y
H
G
D
S
D
L
Q
L
D
R
I
Site 6
S48
D
L
Q
L
D
R
I
S
V
Y
Y
N
E
A
T
Site 7
Y50
Q
L
D
R
I
S
V
Y
Y
N
E
A
T
G
G
Site 8
Y51
L
D
R
I
S
V
Y
Y
N
E
A
T
G
G
K
Site 9
T55
S
V
Y
Y
N
E
A
T
G
G
K
Y
V
P
R
Site 10
Y59
N
E
A
T
G
G
K
Y
V
P
R
A
I
L
V
Site 11
T72
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
Site 12
S75
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Site 13
S78
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
Site 14
S95
D
N
F
V
F
G
Q
S
G
A
G
N
N
W
A
Site 15
Y106
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
Site 16
T107
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
Site 17
S115
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
Site 18
S126
V
V
R
K
E
A
E
S
C
D
C
L
Q
G
F
Site 19
T136
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
Site 20
S138
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
Site 21
T143
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
Site 22
S145
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
Site 23
T149
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
Site 24
S153
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
Site 25
Y159
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
Site 26
T166
Y
P
D
R
I
M
N
T
F
S
V
V
P
S
P
Site 27
S168
D
R
I
M
N
T
F
S
V
V
P
S
P
K
V
Site 28
S172
N
T
F
S
V
V
P
S
P
K
V
S
D
T
V
Site 29
S176
V
V
P
S
P
K
V
S
D
T
V
V
E
P
Y
Site 30
T178
P
S
P
K
V
S
D
T
V
V
E
P
Y
N
A
Site 31
Y183
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Site 32
S188
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
Site 33
T196
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
Site 34
T199
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
Site 35
Y200
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Site 36
Y208
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
Site 37
T218
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
Site 38
T219
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
Site 39
T221
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
Site 40
Y222
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
Site 41
S230
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
Site 42
S234
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
Site 43
T274
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
Y
Site 44
S275
P
G
F
A
P
L
T
S
R
G
S
Q
Q
Y
R
Site 45
S278
A
P
L
T
S
R
G
S
Q
Q
Y
R
A
L
T
Site 46
Y281
T
S
R
G
S
Q
Q
Y
R
A
L
T
V
P
E
Site 47
T285
S
Q
Q
Y
R
A
L
T
V
P
E
L
T
Q
Q
Site 48
Y310
C
D
P
R
H
G
R
Y
L
T
V
A
A
V
F
Site 49
T312
P
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
Site 50
S322
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
Site 51
S338
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
Site 52
S339
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
Site 53
Y340
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
Site 54
T366
R
G
L
K
M
A
V
T
F
I
G
N
S
T
A
Site 55
S382
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
Site 56
Y398
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
Site 57
T409
G
M
D
E
M
E
F
T
E
A
E
S
N
M
N
Site 58
S420
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
Site 59
Y422
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
Site 60
Y425
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
E
E
Site 61
T429
Y
Q
Q
Y
Q
D
A
T
A
E
E
E
E
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation