KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ANXA2
Full Name:
Annexin A2
Alias:
Annexin A2; Annexin II; ANX2; ANX2L4; CAL1H; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2D; P36; PAP-IV; Placental anticoagulant protein IV; Protein I
Type:
Lipid binding protein; Calcium-binding protein
Mass (Da):
38604
Number AA:
339
UniProt ID:
P07355
International Prot ID:
IPI00455315
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005604
GO:0042470
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005544
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
GO:0001501
GO:0032502
GO:0048513
Phosida
TranscriptoNet
STRING
Kinexus Products
Annexin A2 Y238 phosphosite-specific antibody AB-PN504#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN504#Annexin A2 (Y235-L241, human) pY238 phosphopeptide - Powder PE-04ACI99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACI99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
T
V
H
E
I
L
C
Site 2
T3
_
_
_
_
_
M
S
T
V
H
E
I
L
C
K
Site 3
S12
H
E
I
L
C
K
L
S
L
E
G
D
H
S
T
Site 4
S18
L
S
L
E
G
D
H
S
T
P
P
S
A
Y
G
Site 5
T19
S
L
E
G
D
H
S
T
P
P
S
A
Y
G
S
Site 6
S22
G
D
H
S
T
P
P
S
A
Y
G
S
V
K
A
Site 7
Y24
H
S
T
P
P
S
A
Y
G
S
V
K
A
Y
T
Site 8
S26
T
P
P
S
A
Y
G
S
V
K
A
Y
T
N
F
Site 9
Y30
A
Y
G
S
V
K
A
Y
T
N
F
D
A
E
R
Site 10
T31
Y
G
S
V
K
A
Y
T
N
F
D
A
E
R
D
Site 11
T61
V
T
I
V
N
I
L
T
N
R
S
N
A
Q
R
Site 12
Y75
R
Q
D
I
A
F
A
Y
Q
R
R
T
K
K
E
Site 13
T79
A
F
A
Y
Q
R
R
T
K
K
E
L
A
S
A
Site 14
S85
R
T
K
K
E
L
A
S
A
L
K
S
A
L
S
Site 15
S89
E
L
A
S
A
L
K
S
A
L
S
G
H
L
E
Site 16
Y109
L
L
K
T
P
A
Q
Y
D
A
S
E
L
K
A
Site 17
S112
T
P
A
Q
Y
D
A
S
E
L
K
A
S
M
K
Site 18
S117
D
A
S
E
L
K
A
S
M
K
G
L
G
T
D
Site 19
T123
A
S
M
K
G
L
G
T
D
E
D
S
L
I
E
Site 20
S127
G
L
G
T
D
E
D
S
L
I
E
I
I
C
S
Site 21
S134
S
L
I
E
I
I
C
S
R
T
N
Q
E
L
Q
Site 22
T136
I
E
I
I
C
S
R
T
N
Q
E
L
Q
E
I
Site 23
Y147
L
Q
E
I
N
R
V
Y
K
E
M
Y
K
T
D
Site 24
T153
V
Y
K
E
M
Y
K
T
D
L
E
K
D
I
I
Site 25
S161
D
L
E
K
D
I
I
S
D
T
S
G
D
F
R
Site 26
T163
E
K
D
I
I
S
D
T
S
G
D
F
R
K
L
Site 27
S164
K
D
I
I
S
D
T
S
G
D
F
R
K
L
M
Site 28
S184
G
R
R
A
E
D
G
S
V
I
D
Y
E
L
I
Site 29
Y188
E
D
G
S
V
I
D
Y
E
L
I
D
Q
D
A
Site 30
Y199
D
Q
D
A
R
D
L
Y
D
A
G
V
K
R
K
Site 31
T208
A
G
V
K
R
K
G
T
D
V
P
K
W
I
S
Site 32
S215
T
D
V
P
K
W
I
S
I
M
T
E
R
S
V
Site 33
T218
P
K
W
I
S
I
M
T
E
R
S
V
P
H
L
Site 34
Y232
L
Q
K
V
F
D
R
Y
K
S
Y
S
P
Y
D
Site 35
S234
K
V
F
D
R
Y
K
S
Y
S
P
Y
D
M
L
Site 36
Y235
V
F
D
R
Y
K
S
Y
S
P
Y
D
M
L
E
Site 37
S236
F
D
R
Y
K
S
Y
S
P
Y
D
M
L
E
S
Site 38
Y238
R
Y
K
S
Y
S
P
Y
D
M
L
E
S
I
R
Annexin A2 Y238 phosphosite-specific antibody AB-PN504#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN504#Annexin A2 (Y235-L241, human) pY238 phosphopeptide - Powder PE-04ACI99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACI99
Site 39
S243
S
P
Y
D
M
L
E
S
I
R
K
E
V
K
G
Site 40
Y269
C
I
Q
N
K
P
L
Y
F
A
D
R
L
Y
D
Site 41
Y275
L
Y
F
A
D
R
L
Y
D
S
M
K
G
K
G
Site 42
S277
F
A
D
R
L
Y
D
S
M
K
G
K
G
T
R
Site 43
Y311
R
S
E
F
K
R
K
Y
G
K
S
L
Y
Y
Y
Site 44
S314
F
K
R
K
Y
G
K
S
L
Y
Y
Y
I
Q
Q
Site 45
Y316
R
K
Y
G
K
S
L
Y
Y
Y
I
Q
Q
D
T
Site 46
Y317
K
Y
G
K
S
L
Y
Y
Y
I
Q
Q
D
T
K
Site 47
Y318
Y
G
K
S
L
Y
Y
Y
I
Q
Q
D
T
K
G
Site 48
Y327
Q
Q
D
T
K
G
D
Y
Q
K
A
L
L
Y
L
Site 49
Y333
D
Y
Q
K
A
L
L
Y
L
C
G
G
D
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation