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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEFL
Full Name:
Neurofilament light polypeptide
Alias:
68 kDa neurofilament protein; CMT1F; CMT2E; Neurofilament triplet L protein; Neurofilament, light polypeptide; NF68; NF-L
Type:
Cytoskeletal protein
Mass (Da):
61517
Number AA:
543
UniProt ID:
P07196
International Prot ID:
IPI00237671
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0005883
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0008022
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0008089
GO:0019896
GO:0033693
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
S
S
F
S
Y
E
P
Y
Y
Site 2
Y9
S
S
F
S
Y
E
P
Y
Y
S
T
S
Y
K
R
Site 3
Y10
S
F
S
Y
E
P
Y
Y
S
T
S
Y
K
R
R
Site 4
S11
F
S
Y
E
P
Y
Y
S
T
S
Y
K
R
R
Y
Site 5
S13
Y
E
P
Y
Y
S
T
S
Y
K
R
R
Y
V
E
Site 6
Y14
E
P
Y
Y
S
T
S
Y
K
R
R
Y
V
E
T
Site 7
Y18
S
T
S
Y
K
R
R
Y
V
E
T
P
R
V
H
Site 8
T21
Y
K
R
R
Y
V
E
T
P
R
V
H
I
S
S
Site 9
S27
E
T
P
R
V
H
I
S
S
V
R
S
G
Y
S
Site 10
S28
T
P
R
V
H
I
S
S
V
R
S
G
Y
S
T
Site 11
S31
V
H
I
S
S
V
R
S
G
Y
S
T
A
R
S
Site 12
Y33
I
S
S
V
R
S
G
Y
S
T
A
R
S
A
Y
Site 13
S34
S
S
V
R
S
G
Y
S
T
A
R
S
A
Y
S
Site 14
T35
S
V
R
S
G
Y
S
T
A
R
S
A
Y
S
S
Site 15
S38
S
G
Y
S
T
A
R
S
A
Y
S
S
Y
S
A
Site 16
Y40
Y
S
T
A
R
S
A
Y
S
S
Y
S
A
P
V
Site 17
S41
S
T
A
R
S
A
Y
S
S
Y
S
A
P
V
S
Site 18
S42
T
A
R
S
A
Y
S
S
Y
S
A
P
V
S
S
Site 19
Y43
A
R
S
A
Y
S
S
Y
S
A
P
V
S
S
S
Site 20
S44
R
S
A
Y
S
S
Y
S
A
P
V
S
S
S
L
Site 21
S48
S
S
Y
S
A
P
V
S
S
S
L
S
V
R
R
Site 22
S49
S
Y
S
A
P
V
S
S
S
L
S
V
R
R
S
Site 23
S50
Y
S
A
P
V
S
S
S
L
S
V
R
R
S
Y
Site 24
S52
A
P
V
S
S
S
L
S
V
R
R
S
Y
S
S
Site 25
S56
S
S
L
S
V
R
R
S
Y
S
S
S
S
G
S
Site 26
Y57
S
L
S
V
R
R
S
Y
S
S
S
S
G
S
L
Site 27
S58
L
S
V
R
R
S
Y
S
S
S
S
G
S
L
M
Site 28
S59
S
V
R
R
S
Y
S
S
S
S
G
S
L
M
P
Site 29
S60
V
R
R
S
Y
S
S
S
S
G
S
L
M
P
S
Site 30
S61
R
R
S
Y
S
S
S
S
G
S
L
M
P
S
L
Site 31
S63
S
Y
S
S
S
S
G
S
L
M
P
S
L
E
N
Site 32
S67
S
S
G
S
L
M
P
S
L
E
N
L
D
L
S
Site 33
S74
S
L
E
N
L
D
L
S
Q
V
A
A
I
S
N
Site 34
S85
A
I
S
N
D
L
K
S
I
R
T
Q
E
K
A
Site 35
S103
D
L
N
D
R
F
A
S
F
I
E
R
V
H
E
Site 36
S130
L
V
L
R
Q
K
H
S
E
P
S
R
F
R
A
Site 37
Y139
P
S
R
F
R
A
L
Y
E
Q
E
I
R
D
L
Site 38
T170
E
R
E
G
L
E
E
T
L
R
N
L
Q
A
R
Site 39
Y178
L
R
N
L
Q
A
R
Y
E
E
E
V
L
S
R
Site 40
S184
R
Y
E
E
E
V
L
S
R
E
D
A
E
G
R
Site 41
S215
E
L
E
K
R
I
D
S
L
M
D
E
I
S
F
Site 42
S221
D
S
L
M
D
E
I
S
F
L
K
K
V
H
E
Site 43
S255
D
V
T
K
P
D
L
S
A
A
L
K
D
I
R
Site 44
Y265
L
K
D
I
R
A
Q
Y
E
K
L
A
A
K
N
Site 45
S282
N
A
E
E
W
F
K
S
R
F
T
V
L
T
E
Site 46
T285
E
W
F
K
S
R
F
T
V
L
T
E
S
A
A
Site 47
T288
K
S
R
F
T
V
L
T
E
S
A
A
K
N
T
Site 48
S290
R
F
T
V
L
T
E
S
A
A
K
N
T
D
A
Site 49
S306
R
A
A
K
D
E
V
S
E
S
R
R
L
L
K
Site 50
S308
A
K
D
E
V
S
E
S
R
R
L
L
K
A
K
Site 51
T316
R
R
L
L
K
A
K
T
L
E
I
E
A
C
R
Site 52
T361
L
E
N
E
L
R
T
T
K
S
E
M
A
R
Y
Site 53
S363
N
E
L
R
T
T
K
S
E
M
A
R
Y
L
K
Site 54
Y368
T
K
S
E
M
A
R
Y
L
K
E
Y
Q
D
L
Site 55
Y372
M
A
R
Y
L
K
E
Y
Q
D
L
L
N
V
K
Site 56
Y389
L
D
I
E
I
A
A
Y
R
K
L
L
E
G
E
Site 57
T398
K
L
L
E
G
E
E
T
R
L
S
F
T
S
V
Site 58
S401
E
G
E
E
T
R
L
S
F
T
S
V
G
S
I
Site 59
T403
E
E
T
R
L
S
F
T
S
V
G
S
I
T
S
Site 60
S404
E
T
R
L
S
F
T
S
V
G
S
I
T
S
G
Site 61
S407
L
S
F
T
S
V
G
S
I
T
S
G
Y
S
Q
Site 62
T409
F
T
S
V
G
S
I
T
S
G
Y
S
Q
S
S
Site 63
S410
T
S
V
G
S
I
T
S
G
Y
S
Q
S
S
Q
Site 64
Y412
V
G
S
I
T
S
G
Y
S
Q
S
S
Q
V
F
Site 65
S413
G
S
I
T
S
G
Y
S
Q
S
S
Q
V
F
G
Site 66
S415
I
T
S
G
Y
S
Q
S
S
Q
V
F
G
R
S
Site 67
S416
T
S
G
Y
S
Q
S
S
Q
V
F
G
R
S
A
Site 68
Y424
Q
V
F
G
R
S
A
Y
G
G
L
Q
T
S
S
Site 69
S430
A
Y
G
G
L
Q
T
S
S
Y
L
M
S
T
R
Site 70
S431
Y
G
G
L
Q
T
S
S
Y
L
M
S
T
R
S
Site 71
Y432
G
G
L
Q
T
S
S
Y
L
M
S
T
R
S
F
Site 72
S435
Q
T
S
S
Y
L
M
S
T
R
S
F
P
S
Y
Site 73
T436
T
S
S
Y
L
M
S
T
R
S
F
P
S
Y
Y
Site 74
S438
S
Y
L
M
S
T
R
S
F
P
S
Y
Y
T
S
Site 75
S441
M
S
T
R
S
F
P
S
Y
Y
T
S
H
V
Q
Site 76
Y442
S
T
R
S
F
P
S
Y
Y
T
S
H
V
Q
E
Site 77
Y443
T
R
S
F
P
S
Y
Y
T
S
H
V
Q
E
E
Site 78
S445
S
F
P
S
Y
Y
T
S
H
V
Q
E
E
Q
I
Site 79
T457
E
Q
I
E
V
E
E
T
I
E
A
A
K
A
E
Site 80
S472
E
A
K
D
E
P
P
S
E
G
E
A
E
E
E
Site 81
S502
E
E
A
A
K
E
E
S
E
E
A
K
E
E
E
Site 82
T520
E
G
E
E
G
E
E
T
K
E
A
E
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation