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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPM1
Full Name:
Nucleophosmin
Alias:
B23; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (Nucleolar phosphoprotein B23, numatrin); Nucleophosmin/B23.2; Numatrin
Type:
RNA binding protein
Mass (Da):
32575
Number AA:
294
UniProt ID:
P06748
International Prot ID:
IPI00549248
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031616
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0030957
GO:0042393
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0007569
GO:0007098
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
D
S
M
D
M
D
M
S
P
Site 2
S10
D
S
M
D
M
D
M
S
P
L
R
P
Q
N
Y
Site 3
Y17
S
P
L
R
P
Q
N
Y
L
F
G
C
E
L
K
Site 4
Y29
E
L
K
A
D
K
D
Y
H
F
K
V
D
N
D
Site 5
S43
D
E
N
E
H
Q
L
S
L
R
T
V
S
L
G
Site 6
S48
Q
L
S
L
R
T
V
S
L
G
A
G
A
K
D
Site 7
Y67
V
E
A
E
A
M
N
Y
E
G
S
P
I
K
V
Site 8
S70
E
A
M
N
Y
E
G
S
P
I
K
V
T
L
A
Site 9
T75
E
G
S
P
I
K
V
T
L
A
T
L
K
M
S
Site 10
T78
P
I
K
V
T
L
A
T
L
K
M
S
V
Q
P
Site 11
S82
T
L
A
T
L
K
M
S
V
Q
P
T
V
S
L
Site 12
S88
M
S
V
Q
P
T
V
S
L
G
G
F
E
I
T
Site 13
T95
S
L
G
G
F
E
I
T
P
P
V
V
L
R
L
Site 14
S106
V
L
R
L
K
C
G
S
G
P
V
H
I
S
G
Site 15
S112
G
S
G
P
V
H
I
S
G
Q
H
L
V
A
V
Site 16
S125
A
V
E
E
D
A
E
S
E
D
E
E
E
E
D
Site 17
S137
E
E
D
V
K
L
L
S
I
S
G
K
R
S
A
Site 18
S139
D
V
K
L
L
S
I
S
G
K
R
S
A
P
G
Site 19
S143
L
S
I
S
G
K
R
S
A
P
G
G
G
S
K
Site 20
S195
E
K
A
P
V
K
K
S
I
R
D
T
P
A
K
Site 21
T199
V
K
K
S
I
R
D
T
P
A
K
N
A
Q
K
Site 22
S207
P
A
K
N
A
Q
K
S
N
Q
N
G
K
D
S
Site 23
S214
S
N
Q
N
G
K
D
S
K
P
S
S
T
P
R
Site 24
S217
N
G
K
D
S
K
P
S
S
T
P
R
S
K
G
Site 25
S218
G
K
D
S
K
P
S
S
T
P
R
S
K
G
Q
Site 26
T219
K
D
S
K
P
S
S
T
P
R
S
K
G
Q
E
Site 27
S222
K
P
S
S
T
P
R
S
K
G
Q
E
S
F
K
Site 28
S227
P
R
S
K
G
Q
E
S
F
K
K
Q
E
K
T
Site 29
T234
S
F
K
K
Q
E
K
T
P
K
T
P
K
G
P
Site 30
T237
K
Q
E
K
T
P
K
T
P
K
G
P
S
S
V
Site 31
S242
P
K
T
P
K
G
P
S
S
V
E
D
I
K
A
Site 32
S243
K
T
P
K
G
P
S
S
V
E
D
I
K
A
K
Site 33
S254
I
K
A
K
M
Q
A
S
I
E
K
G
G
S
L
Site 34
S260
A
S
I
E
K
G
G
S
L
P
K
V
E
A
K
Site 35
T279
V
K
N
C
F
R
M
T
D
Q
E
A
I
Q
D
Site 36
S293
D
L
W
Q
W
R
K
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation