KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GPI
Full Name:
Glucose-6-phosphate isomerase
Alias:
AMF; Autocrine motility factor; Glucose phosphate isomerase; GNPI; Neuroleukin; NLK; Oxoisomerase; PGI; PHI; Phosphoglucose isomerase; Phosphohexose isomerase; SA-36; Sperm antigen-36
Type:
Apoptosis; EC 5.3.1.9; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Cytokine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Isomerase; Carbohydrate Metabolism - pentose phosphate pathway
Mass (Da):
63147
Number AA:
558
UniProt ID:
P06744
International Prot ID:
IPI00027497
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0004347
GO:0008083
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0006094
GO:0006096
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
F
Q
K
L
Q
Q
W
Y
R
E
H
R
S
E
L
Site 2
S22
Q
W
Y
R
E
H
R
S
E
L
N
L
R
R
L
Site 3
Y55
H
G
H
I
L
V
D
Y
S
K
N
L
V
T
E
Site 4
T61
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
Site 5
Y92
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
Site 6
T93
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
Site 7
S107
H
V
A
L
R
N
R
S
N
T
P
I
L
V
D
Site 8
T109
A
L
R
N
R
S
N
T
P
I
L
V
D
G
K
Site 9
S131
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
Site 10
Y174
V
T
E
A
L
K
P
Y
S
S
G
G
P
R
V
Site 11
S175
T
E
A
L
K
P
Y
S
S
G
G
P
R
V
W
Site 12
S176
E
A
L
K
P
Y
S
S
G
G
P
R
V
W
Y
Site 13
Y183
S
G
G
P
R
V
W
Y
V
S
N
I
D
G
T
Site 14
S185
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
Site 15
T190
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Site 16
T195
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
Site 17
T214
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
Site 18
T215
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
Site 19
S237
L
Q
A
A
K
D
P
S
A
V
A
K
H
F
V
Site 20
T310
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
Site 21
Y344
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
Site 22
Y351
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
Site 23
Y363
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
Site 24
S367
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
Site 25
T375
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
Site 26
Y392
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
Site 27
T412
D
F
L
I
P
V
Q
T
Q
H
P
I
R
K
G
Site 28
S441
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
Site 29
S455
E
L
Q
A
A
G
K
S
P
E
D
L
E
R
L
Site 30
T474
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
Site 31
S476
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
Site 32
S532
I
E
P
E
L
D
G
S
A
Q
V
T
S
H
D
Site 33
T536
L
D
G
S
A
Q
V
T
S
H
D
A
S
T
N
Site 34
S537
D
G
S
A
Q
V
T
S
H
D
A
S
T
N
G
Site 35
S541
Q
V
T
S
H
D
A
S
T
N
G
L
I
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation