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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GSN
Full Name:
Gelsolin
Alias:
Actin-depolymerizing factor
Type:
Actin binding protein
Mass (Da):
85698
Number AA:
782
UniProt ID:
P06396
International Prot ID:
IPI00026314
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005737
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006461
GO:0006810
GO:0008064
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
Site 2
S31
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
Site 3
S35
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
Site 4
S51
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
Site 5
Y86
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
Site 6
T100
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
Site 7
Y114
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
S
Site 8
S121
Y
W
L
G
N
E
C
S
Q
D
E
S
G
A
A
Site 9
S125
N
E
C
S
Q
D
E
S
G
A
A
A
I
F
T
Site 10
Y138
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
Site 11
S154
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
Site 12
Y160
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
Site 13
S163
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
Site 14
Y167
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
Site 15
T201
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
Site 16
S206
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
Site 17
Y235
C
G
S
N
S
N
R
Y
E
R
L
K
A
T
Q
Site 18
T241
R
Y
E
R
L
K
A
T
Q
V
S
K
G
I
R
Site 19
S253
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
Site 20
S261
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
Site 21
T265
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
Site 22
Y301
N
R
K
L
A
K
L
Y
K
V
S
N
G
A
G
Site 23
T361
E
R
K
A
A
L
K
T
A
S
D
F
I
T
K
Site 24
S363
K
A
A
L
K
T
A
S
D
F
I
T
K
M
D
Site 25
T367
K
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
Site 26
Y371
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
Site 27
S378
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
Site 28
T402
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
Site 29
S408
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
Site 30
Y409
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
Site 31
T464
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
Site 32
Y465
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
Site 33
Y469
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
Site 34
S473
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
Site 35
Y474
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
R
Site 36
Y478
G
D
S
Y
I
I
L
Y
N
Y
R
H
G
G
R
Site 37
Y480
S
Y
I
I
L
Y
N
Y
R
H
G
G
R
Q
G
Site 38
Y491
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
Site 39
T520
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Site 40
S524
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
Site 41
Y547
G
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
Site 42
T558
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
Site 43
S562
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
Site 44
S590
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
Site 45
Y603
L
K
T
P
S
A
A
Y
L
W
V
G
T
G
A
Site 46
T616
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
Site 47
S636
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
Site 48
Y651
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
Site 49
S654
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
K
Site 50
S715
F
V
W
V
G
K
D
S
Q
E
E
E
K
T
E
Site 51
T721
D
S
Q
E
E
E
K
T
E
A
L
T
S
A
K
Site 52
S726
E
K
T
E
A
L
T
S
A
K
R
Y
I
E
T
Site 53
Y730
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
Site 54
T742
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
Site 55
T745
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
Site 56
S755
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
Site 57
Y767
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation