KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KRT8
Full Name:
Keratin, type II cytoskeletal 8
Alias:
CARD2; CK 8; CK8; CYK8; Cytokeratin 8; Cytokeratin endo A; K2C8; K8; Keratin 8; Keratin, type II cytoskeletal 8; KO; KRT2-8
Type:
Cytoskeletal protein
Mass (Da):
53704
Number AA:
483
UniProt ID:
P05787
International Prot ID:
IPI00554648
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0045095
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0044419
GO:0009607
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
I
R
V
T
Q
K
S
Site 2
S9
S
I
R
V
T
Q
K
S
Y
K
V
S
T
S
G
Site 3
Y10
I
R
V
T
Q
K
S
Y
K
V
S
T
S
G
P
Site 4
S13
T
Q
K
S
Y
K
V
S
T
S
G
P
R
A
F
Site 5
T14
Q
K
S
Y
K
V
S
T
S
G
P
R
A
F
S
Site 6
S15
K
S
Y
K
V
S
T
S
G
P
R
A
F
S
S
Site 7
S21
T
S
G
P
R
A
F
S
S
R
S
Y
T
S
G
Site 8
S22
S
G
P
R
A
F
S
S
R
S
Y
T
S
G
P
Site 9
S24
P
R
A
F
S
S
R
S
Y
T
S
G
P
G
S
Site 10
Y25
R
A
F
S
S
R
S
Y
T
S
G
P
G
S
R
Site 11
T26
A
F
S
S
R
S
Y
T
S
G
P
G
S
R
I
Site 12
S27
F
S
S
R
S
Y
T
S
G
P
G
S
R
I
S
Site 13
S31
S
Y
T
S
G
P
G
S
R
I
S
S
S
S
F
Site 14
S34
S
G
P
G
S
R
I
S
S
S
S
F
S
R
V
Site 15
S35
G
P
G
S
R
I
S
S
S
S
F
S
R
V
G
Site 16
S36
P
G
S
R
I
S
S
S
S
F
S
R
V
G
S
Site 17
S37
G
S
R
I
S
S
S
S
F
S
R
V
G
S
S
Site 18
S39
R
I
S
S
S
S
F
S
R
V
G
S
S
N
F
Site 19
S43
S
S
F
S
R
V
G
S
S
N
F
R
G
G
L
Site 20
S44
S
F
S
R
V
G
S
S
N
F
R
G
G
L
G
Site 21
Y54
R
G
G
L
G
G
G
Y
G
G
A
S
G
M
G
Site 22
T64
A
S
G
M
G
G
I
T
A
V
T
V
N
Q
S
Site 23
T67
M
G
G
I
T
A
V
T
V
N
Q
S
L
L
S
Site 24
S74
T
V
N
Q
S
L
L
S
P
L
V
L
E
V
D
Site 25
T89
P
N
I
Q
A
V
R
T
Q
E
K
E
Q
I
K
Site 26
T97
Q
E
K
E
Q
I
K
T
L
N
N
K
F
A
S
Site 27
S104
T
L
N
N
K
F
A
S
F
I
D
K
V
R
F
Site 28
S124
K
M
L
E
T
K
W
S
L
L
Q
Q
Q
K
T
Site 29
T131
S
L
L
Q
Q
Q
K
T
A
R
S
N
M
D
N
Site 30
Y143
M
D
N
M
F
E
S
Y
I
N
N
L
R
R
Q
Site 31
T153
N
L
R
R
Q
L
E
T
L
G
Q
E
K
L
K
Site 32
Y179
V
E
D
F
K
N
K
Y
E
D
E
I
N
K
R
Site 33
T187
E
D
E
I
N
K
R
T
E
M
E
N
E
F
V
Site 34
Y204
K
K
D
V
D
E
A
Y
M
N
K
V
E
L
E
Site 35
S212
M
N
K
V
E
L
E
S
R
L
E
G
L
T
D
Site 36
T218
E
S
R
L
E
G
L
T
D
E
I
N
F
L
R
Site 37
Y228
I
N
F
L
R
Q
L
Y
E
E
E
I
R
E
L
Site 38
S237
E
E
I
R
E
L
Q
S
Q
I
S
D
T
S
V
Site 39
S240
R
E
L
Q
S
Q
I
S
D
T
S
V
V
L
S
Site 40
T242
L
Q
S
Q
I
S
D
T
S
V
V
L
S
M
D
Site 41
S243
Q
S
Q
I
S
D
T
S
V
V
L
S
M
D
N
Site 42
S247
S
D
T
S
V
V
L
S
M
D
N
S
R
S
L
Site 43
S251
V
V
L
S
M
D
N
S
R
S
L
D
M
D
S
Site 44
S253
L
S
M
D
N
S
R
S
L
D
M
D
S
I
I
Site 45
S258
S
R
S
L
D
M
D
S
I
I
A
E
V
K
A
Site 46
Y267
I
A
E
V
K
A
Q
Y
E
D
I
A
N
R
S
Site 47
S274
Y
E
D
I
A
N
R
S
R
A
E
A
E
S
M
Site 48
S280
R
S
R
A
E
A
E
S
M
Y
Q
I
K
Y
E
Site 49
Y282
R
A
E
A
E
S
M
Y
Q
I
K
Y
E
E
L
Site 50
Y286
E
S
M
Y
Q
I
K
Y
E
E
L
Q
S
L
A
Site 51
S291
I
K
Y
E
E
L
Q
S
L
A
G
K
H
G
D
Site 52
T303
H
G
D
D
L
R
R
T
K
T
E
I
S
E
M
Site 53
T305
D
D
L
R
R
T
K
T
E
I
S
E
M
N
R
Site 54
S308
R
R
T
K
T
E
I
S
E
M
N
R
N
I
S
Site 55
S315
S
E
M
N
R
N
I
S
R
L
Q
A
E
I
E
Site 56
S330
G
L
K
G
Q
R
A
S
L
E
A
A
I
A
D
Site 57
Y374
M
A
R
Q
L
R
E
Y
Q
E
L
M
N
V
K
Site 58
Y391
L
D
I
E
I
A
T
Y
R
K
L
L
E
G
E
Site 59
S400
K
L
L
E
G
E
E
S
R
L
E
S
G
M
Q
Site 60
S404
G
E
E
S
R
L
E
S
G
M
Q
N
M
S
I
Site 61
S410
E
S
G
M
Q
N
M
S
I
H
T
K
T
T
S
Site 62
T415
N
M
S
I
H
T
K
T
T
S
G
Y
A
G
G
Site 63
T416
M
S
I
H
T
K
T
T
S
G
Y
A
G
G
L
Site 64
S417
S
I
H
T
K
T
T
S
G
Y
A
G
G
L
S
Site 65
Y419
H
T
K
T
T
S
G
Y
A
G
G
L
S
S
A
Site 66
S424
S
G
Y
A
G
G
L
S
S
A
Y
G
G
L
T
Site 67
Y427
A
G
G
L
S
S
A
Y
G
G
L
T
S
P
G
Site 68
T431
S
S
A
Y
G
G
L
T
S
P
G
L
S
Y
S
Site 69
S432
S
A
Y
G
G
L
T
S
P
G
L
S
Y
S
L
Site 70
S436
G
L
T
S
P
G
L
S
Y
S
L
G
S
S
F
Site 71
Y437
L
T
S
P
G
L
S
Y
S
L
G
S
S
F
G
Site 72
S438
T
S
P
G
L
S
Y
S
L
G
S
S
F
G
S
Site 73
S441
G
L
S
Y
S
L
G
S
S
F
G
S
G
A
G
Site 74
S442
L
S
Y
S
L
G
S
S
F
G
S
G
A
G
S
Site 75
S445
S
L
G
S
S
F
G
S
G
A
G
S
S
S
F
Site 76
S449
S
F
G
S
G
A
G
S
S
S
F
S
R
T
S
Site 77
S450
F
G
S
G
A
G
S
S
S
F
S
R
T
S
S
Site 78
S451
G
S
G
A
G
S
S
S
F
S
R
T
S
S
S
Site 79
S453
G
A
G
S
S
S
F
S
R
T
S
S
S
R
A
Site 80
T455
G
S
S
S
F
S
R
T
S
S
S
R
A
V
V
Site 81
S456
S
S
S
F
S
R
T
S
S
S
R
A
V
V
V
Site 82
S457
S
S
F
S
R
T
S
S
S
R
A
V
V
V
K
Site 83
S458
S
F
S
R
T
S
S
S
R
A
V
V
V
K
K
Site 84
S475
T
R
D
G
K
L
V
S
E
S
S
D
V
L
P
Site 85
S477
D
G
K
L
V
S
E
S
S
D
V
L
P
K
_
Site 86
S478
G
K
L
V
S
E
S
S
D
V
L
P
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation