KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KRT18
Full Name:
Keratin, type I cytoskeletal 18
Alias:
CYK18; Cytokeratin-18; K18
Type:
Cytoskeletal protein
Mass (Da):
48058
Number AA:
430
UniProt ID:
P05783
International Prot ID:
IPI00784347
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034451
GO:0045095
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0043000
GO:0009653
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
F
T
T
R
S
T
F
S
T
N
Y
R
Site 2
T8
M
S
F
T
T
R
S
T
F
S
T
N
Y
R
S
Site 3
S10
F
T
T
R
S
T
F
S
T
N
Y
R
S
L
G
Site 4
T11
T
T
R
S
T
F
S
T
N
Y
R
S
L
G
S
Site 5
Y13
R
S
T
F
S
T
N
Y
R
S
L
G
S
V
Q
Site 6
S15
T
F
S
T
N
Y
R
S
L
G
S
V
Q
A
P
Site 7
S18
T
N
Y
R
S
L
G
S
V
Q
A
P
S
Y
G
Site 8
S23
L
G
S
V
Q
A
P
S
Y
G
A
R
P
V
S
Site 9
Y24
G
S
V
Q
A
P
S
Y
G
A
R
P
V
S
S
Site 10
S30
S
Y
G
A
R
P
V
S
S
A
A
S
V
Y
A
Site 11
S31
Y
G
A
R
P
V
S
S
A
A
S
V
Y
A
G
Site 12
S34
R
P
V
S
S
A
A
S
V
Y
A
G
A
G
G
Site 13
Y36
V
S
S
A
A
S
V
Y
A
G
A
G
G
S
G
Site 14
S42
V
Y
A
G
A
G
G
S
G
S
R
I
S
V
S
Site 15
S44
A
G
A
G
G
S
G
S
R
I
S
V
S
R
S
Site 16
S47
G
G
S
G
S
R
I
S
V
S
R
S
T
S
F
Site 17
S49
S
G
S
R
I
S
V
S
R
S
T
S
F
R
G
Site 18
S51
S
R
I
S
V
S
R
S
T
S
F
R
G
G
M
Site 19
T52
R
I
S
V
S
R
S
T
S
F
R
G
G
M
G
Site 20
S53
I
S
V
S
R
S
T
S
F
R
G
G
M
G
S
Site 21
S60
S
F
R
G
G
M
G
S
G
G
L
A
T
G
I
Site 22
T65
M
G
S
G
G
L
A
T
G
I
A
G
G
L
A
Site 23
S86
N
E
K
E
T
M
Q
S
L
N
D
R
L
A
S
Site 24
S93
S
L
N
D
R
L
A
S
Y
L
D
R
V
R
S
Site 25
Y94
L
N
D
R
L
A
S
Y
L
D
R
V
R
S
L
Site 26
S100
S
Y
L
D
R
V
R
S
L
E
T
E
N
R
R
Site 27
S110
T
E
N
R
R
L
E
S
K
I
R
E
H
L
E
Site 28
S127
G
P
Q
V
R
D
W
S
H
Y
F
K
I
I
E
Site 29
Y129
Q
V
R
D
W
S
H
Y
F
K
I
I
E
D
L
Site 30
T144
R
A
Q
I
F
A
N
T
V
D
N
A
R
I
V
Site 31
Y168
A
D
D
F
R
V
K
Y
E
T
E
L
A
M
R
Site 32
T170
D
F
R
V
K
Y
E
T
E
L
A
M
R
Q
S
Site 33
S177
T
E
L
A
M
R
Q
S
V
E
N
D
I
H
G
Site 34
T192
L
R
K
V
I
D
D
T
N
I
T
R
L
Q
L
Site 35
T234
Q
I
A
S
S
G
L
T
V
E
V
D
A
P
K
Site 36
S242
V
E
V
D
A
P
K
S
Q
D
L
A
K
I
M
Site 37
Y256
M
A
D
I
R
A
Q
Y
D
E
L
A
R
K
N
Site 38
Y270
N
R
E
E
L
D
K
Y
W
S
Q
Q
I
E
E
Site 39
S272
E
E
L
D
K
Y
W
S
Q
Q
I
E
E
S
T
Site 40
T280
Q
Q
I
E
E
S
T
T
V
V
T
T
Q
S
A
Site 41
T297
G
A
A
E
T
T
L
T
E
L
R
R
T
V
Q
Site 42
T302
T
L
T
E
L
R
R
T
V
Q
S
L
E
I
D
Site 43
S305
E
L
R
R
T
V
Q
S
L
E
I
D
L
D
S
Site 44
S312
S
L
E
I
D
L
D
S
M
R
N
L
K
A
S
Site 45
S319
S
M
R
N
L
K
A
S
L
E
N
S
L
R
E
Site 46
S323
L
K
A
S
L
E
N
S
L
R
E
V
E
A
R
Site 47
Y331
L
R
E
V
E
A
R
Y
A
L
Q
M
E
Q
L
Site 48
T352
L
E
S
E
L
A
Q
T
R
A
E
G
Q
R
Q
Site 49
Y363
G
Q
R
Q
A
Q
E
Y
E
A
L
L
N
I
K
Site 50
T379
K
L
E
A
E
I
A
T
Y
R
R
L
L
E
D
Site 51
Y380
L
E
A
E
I
A
T
Y
R
R
L
L
E
D
G
Site 52
S398
N
L
G
D
A
L
D
S
S
N
S
M
Q
T
I
Site 53
S399
L
G
D
A
L
D
S
S
N
S
M
Q
T
I
Q
Site 54
S401
D
A
L
D
S
S
N
S
M
Q
T
I
Q
K
T
Site 55
T404
D
S
S
N
S
M
Q
T
I
Q
K
T
T
T
R
Site 56
T408
S
M
Q
T
I
Q
K
T
T
T
R
R
I
V
D
Site 57
T409
M
Q
T
I
Q
K
T
T
T
R
R
I
V
D
G
Site 58
S420
I
V
D
G
K
V
V
S
E
T
N
D
T
K
V
Site 59
T425
V
V
S
E
T
N
D
T
K
V
L
R
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation