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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ER-alpha
Full Name:
Estrogen receptor
Alias:
ER; Era; ESR; ESR1; ESTR; ESTRA; Estradiol receptor; estrogen receptor 1; NR3A1
Type:
Transcription protein (receptor)
Mass (Da):
66216
Number AA:
595
UniProt ID:
P03372
International Prot ID:
IPI00294982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016585
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0030284
GO:0034056
GO:0030235
PhosphoSite+
KinaseNET
Biological Process:
GO:0030520
GO:0048386
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
M
T
L
H
T
K
A
Site 2
T4
_
_
_
_
M
T
M
T
L
H
T
K
A
S
G
Site 3
T7
_
M
T
M
T
L
H
T
K
A
S
G
M
A
L
Site 4
S10
M
T
L
H
T
K
A
S
G
M
A
L
L
H
Q
Site 5
Y43
E
R
P
L
G
E
V
Y
L
D
S
S
K
P
A
Site 6
S46
L
G
E
V
Y
L
D
S
S
K
P
A
V
Y
N
Site 7
S47
G
E
V
Y
L
D
S
S
K
P
A
V
Y
N
Y
Site 8
Y52
D
S
S
K
P
A
V
Y
N
Y
P
E
G
A
A
Site 9
Y54
S
K
P
A
V
Y
N
Y
P
E
G
A
A
Y
E
Site 10
Y60
N
Y
P
E
G
A
A
Y
E
F
N
A
A
A
A
Site 11
Y73
A
A
A
N
A
Q
V
Y
G
Q
T
G
L
P
Y
Site 12
Y80
Y
G
Q
T
G
L
P
Y
G
P
G
S
E
A
A
Site 13
S84
G
L
P
Y
G
P
G
S
E
A
A
A
F
G
S
Site 14
S91
S
E
A
A
A
F
G
S
N
G
L
G
G
F
P
Site 15
S102
G
G
F
P
P
L
N
S
V
S
P
S
P
L
M
Site 16
S104
F
P
P
L
N
S
V
S
P
S
P
L
M
L
L
Site 17
S106
P
L
N
S
V
S
P
S
P
L
M
L
L
H
P
Site 18
S118
L
H
P
P
P
Q
L
S
P
F
L
Q
P
H
G
Site 19
Y131
H
G
Q
Q
V
P
Y
Y
L
E
N
E
P
S
G
Site 20
S137
Y
Y
L
E
N
E
P
S
G
Y
T
V
R
E
A
Site 21
Y139
L
E
N
E
P
S
G
Y
T
V
R
E
A
G
P
Site 22
T140
E
N
E
P
S
G
Y
T
V
R
E
A
G
P
P
Site 23
Y150
E
A
G
P
P
A
F
Y
R
P
N
S
D
N
R
Site 24
S154
P
A
F
Y
R
P
N
S
D
N
R
R
Q
G
G
Site 25
S167
G
G
R
E
R
L
A
S
T
N
D
K
G
S
M
Site 26
S173
A
S
T
N
D
K
G
S
M
A
M
E
S
A
K
Site 27
Y184
E
S
A
K
E
T
R
Y
C
A
V
C
N
D
Y
Site 28
Y191
Y
C
A
V
C
N
D
Y
A
S
G
Y
H
Y
G
Site 29
Y197
D
Y
A
S
G
Y
H
Y
G
V
W
S
C
E
G
Site 30
S212
C
K
A
F
F
K
R
S
I
Q
G
H
N
D
Y
Site 31
Y219
S
I
Q
G
H
N
D
Y
M
C
P
A
T
N
Q
Site 32
S236
I
D
K
N
R
R
K
S
C
Q
A
C
R
L
R
Site 33
Y246
A
C
R
L
R
K
C
Y
E
V
G
M
M
K
G
Site 34
S282
E
G
R
G
E
V
G
S
A
G
D
M
R
A
A
Site 35
S294
R
A
A
N
L
W
P
S
P
L
M
I
K
R
S
Site 36
S301
S
P
L
M
I
K
R
S
K
K
N
S
L
A
L
Site 37
S305
I
K
R
S
K
K
N
S
L
A
L
S
L
T
A
Site 38
S309
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
Site 39
T311
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
Site 40
Y328
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
Site 41
S329
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
Site 42
Y331
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
Site 43
T334
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
Site 44
S338
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
Site 45
S341
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
Site 46
S464
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
Site 47
S468
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
Site 48
T485
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
Site 49
S518
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Site 50
Y526
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
Site 51
Y537
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
Site 52
T553
A
H
R
L
H
A
P
T
S
R
G
G
A
S
V
Site 53
S554
H
R
L
H
A
P
T
S
R
G
G
A
S
V
E
Site 54
S559
P
T
S
R
G
G
A
S
V
E
E
T
D
Q
S
Site 55
T563
G
G
A
S
V
E
E
T
D
Q
S
H
L
A
T
Site 56
S566
S
V
E
E
T
D
Q
S
H
L
A
T
A
G
S
Site 57
T570
T
D
Q
S
H
L
A
T
A
G
S
T
S
S
H
Site 58
S573
S
H
L
A
T
A
G
S
T
S
S
H
S
L
Q
Site 59
S575
L
A
T
A
G
S
T
S
S
H
S
L
Q
K
Y
Site 60
S576
A
T
A
G
S
T
S
S
H
S
L
Q
K
Y
Y
Site 61
S578
A
G
S
T
S
S
H
S
L
Q
K
Y
Y
I
T
Site 62
Y582
S
S
H
S
L
Q
K
Y
Y
I
T
G
E
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation