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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
uPA (Plasminogen)
Full Name:
Urokinase-type plasminogen activator
Alias:
Type:
Protease
Mass (Da):
48525
Number AA:
431
UniProt ID:
P00749
International Prot ID:
IPI00296180
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0007596
GO:0006935
GO:0042730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
C
V
L
V
V
S
D
S
K
G
S
N
E
L
H
Site 2
T38
C
D
C
L
N
G
G
T
C
V
S
N
K
Y
F
Site 3
S41
L
N
G
G
T
C
V
S
N
K
Y
F
S
N
I
Site 4
Y71
I
D
K
S
K
T
C
Y
E
G
N
G
H
F
Y
Site 5
T84
F
Y
R
G
K
A
S
T
D
T
M
G
R
P
C
Site 6
T86
R
G
K
A
S
T
D
T
M
G
R
P
C
L
P
Site 7
Y121
L
G
L
G
K
H
N
Y
C
R
N
P
D
N
R
Site 8
Y134
N
R
R
R
P
W
C
Y
V
Q
V
G
L
K
P
Site 9
S158
C
A
D
G
K
K
P
S
S
P
P
E
E
L
K
Site 10
S159
A
D
G
K
K
P
S
S
P
P
E
E
L
K
F
Site 11
T172
K
F
Q
C
G
Q
K
T
L
R
P
R
F
K
I
Site 12
Y197
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
Site 13
S204
Y
R
R
H
R
G
G
S
V
T
Y
V
C
G
G
Site 14
T206
R
H
R
G
G
S
V
T
Y
V
C
G
G
S
L
Site 15
Y229
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
Site 16
Y235
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
Site 17
Y238
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
Site 18
S246
L
G
R
S
R
L
N
S
N
T
Q
G
E
M
K
Site 19
T248
R
S
R
L
N
S
N
T
Q
G
E
M
K
F
E
Site 20
Y265
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
Site 21
S266
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
Site 22
S283
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
Site 23
S292
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
Site 24
T297
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
Site 25
Y304
T
I
C
L
P
S
M
Y
N
D
P
Q
F
G
T
Site 26
T316
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
Site 27
S323
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Site 28
Y326
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
Site 29
Y328
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
Site 30
T335
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
Site 31
Y350
R
E
C
Q
Q
P
H
Y
Y
G
S
E
V
T
T
Site 32
Y351
E
C
Q
Q
P
H
Y
Y
G
S
E
V
T
T
K
Site 33
T369
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
Site 34
S371
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
Site 35
Y409
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
Site 36
T423
L
P
W
I
R
S
H
T
K
E
E
N
G
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation