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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C1R
Full Name:
Complement C1r subcomponent
Alias:
C1RA; Complement C1r component precursor; complement component 1, r subcomponent
Type:
EC 3.4.21.41; Protease
Mass (Da):
80119
Number AA:
705
UniProt ID:
P00736
International Prot ID:
IPI00296165
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006958
GO:0045087
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
Q
K
L
F
G
E
V
T
S
P
L
F
P
K
P
Site 2
S31
K
L
F
G
E
V
T
S
P
L
F
P
K
P
Y
Site 3
Y38
S
P
L
F
P
K
P
Y
P
N
N
F
E
T
T
Site 4
T46
P
N
N
F
E
T
T
T
V
I
T
V
P
T
G
Site 5
Y73
E
P
S
E
G
C
F
Y
D
Y
V
K
I
S
A
Site 6
Y75
S
E
G
C
F
Y
D
Y
V
K
I
S
A
D
K
Site 7
S79
F
Y
D
Y
V
K
I
S
A
D
K
K
S
L
G
Site 8
S84
K
I
S
A
D
K
K
S
L
G
R
F
C
G
Q
Site 9
S94
R
F
C
G
Q
L
G
S
P
L
G
N
P
P
G
Site 10
S107
P
G
K
K
E
F
M
S
Q
G
N
K
M
L
L
Site 11
T115
Q
G
N
K
M
L
L
T
F
H
T
D
F
S
N
Site 12
S121
L
T
F
H
T
D
F
S
N
E
E
N
G
T
I
Site 13
Y138
Y
K
G
F
L
A
Y
Y
Q
A
V
D
L
D
E
Site 14
S148
V
D
L
D
E
C
A
S
R
S
K
S
G
E
E
Site 15
S150
L
D
E
C
A
S
R
S
K
S
G
E
E
D
P
Site 16
S152
E
C
A
S
R
S
K
S
G
E
E
D
P
Q
P
Site 17
Y172
C
H
N
Y
V
G
G
Y
F
C
S
C
R
P
G
Site 18
Y180
F
C
S
C
R
P
G
Y
E
L
Q
E
D
T
H
Site 19
S188
E
L
Q
E
D
T
H
S
C
Q
A
E
C
S
S
Site 20
Y198
A
E
C
S
S
E
L
Y
T
E
A
S
G
Y
I
Site 21
T199
E
C
S
S
E
L
Y
T
E
A
S
G
Y
I
S
Site 22
S202
S
E
L
Y
T
E
A
S
G
Y
I
S
S
L
E
Site 23
Y204
L
Y
T
E
A
S
G
Y
I
S
S
L
E
Y
P
Site 24
S206
T
E
A
S
G
Y
I
S
S
L
E
Y
P
R
S
Site 25
S207
E
A
S
G
Y
I
S
S
L
E
Y
P
R
S
Y
Site 26
Y210
G
Y
I
S
S
L
E
Y
P
R
S
Y
P
P
D
Site 27
S213
S
S
L
E
Y
P
R
S
Y
P
P
D
L
R
C
Site 28
Y214
S
L
E
Y
P
R
S
Y
P
P
D
L
R
C
N
Site 29
Y222
P
P
D
L
R
C
N
Y
S
I
R
V
E
R
G
Site 30
S223
P
D
L
R
C
N
Y
S
I
R
V
E
R
G
L
Site 31
Y258
P
Y
D
Q
L
Q
I
Y
A
N
G
K
N
I
G
Site 32
T278
Q
R
P
P
D
L
D
T
S
S
N
A
V
D
L
Site 33
S280
P
P
D
L
D
T
S
S
N
A
V
D
L
L
F
Site 34
T289
A
V
D
L
L
F
F
T
D
E
S
G
D
S
R
Site 35
S292
L
L
F
F
T
D
E
S
G
D
S
R
G
W
K
Site 36
S295
F
T
D
E
S
G
D
S
R
G
W
K
L
R
Y
Site 37
Y302
S
R
G
W
K
L
R
Y
T
T
E
I
I
K
C
Site 38
T303
R
G
W
K
L
R
Y
T
T
E
I
I
K
C
P
Site 39
T314
I
K
C
P
Q
P
K
T
L
D
E
F
T
I
I
Site 40
Y328
I
Q
N
L
Q
P
Q
Y
Q
F
R
D
Y
F
I
Site 41
Y333
P
Q
Y
Q
F
R
D
Y
F
I
A
T
C
K
Q
Site 42
Y342
I
A
T
C
K
Q
G
Y
Q
L
I
E
G
N
Q
Site 43
S353
E
G
N
Q
V
L
H
S
F
T
A
V
C
Q
D
Site 44
Y389
L
P
N
G
D
F
R
Y
T
T
T
M
G
V
N
Site 45
T390
P
N
G
D
F
R
Y
T
T
T
M
G
V
N
T
Site 46
Y398
T
T
M
G
V
N
T
Y
K
A
R
I
Q
Y
Y
Site 47
Y404
T
Y
K
A
R
I
Q
Y
Y
C
H
E
P
Y
Y
Site 48
Y411
Y
Y
C
H
E
P
Y
Y
K
M
Q
T
R
A
G
Site 49
T415
E
P
Y
Y
K
M
Q
T
R
A
G
S
R
E
S
Site 50
S419
K
M
Q
T
R
A
G
S
R
E
S
E
Q
G
V
Site 51
S422
T
R
A
G
S
R
E
S
E
Q
G
V
Y
T
C
Site 52
Y427
R
E
S
E
Q
G
V
Y
T
C
T
A
Q
G
I
Site 53
T503
W
I
L
T
A
A
H
T
L
Y
P
K
E
H
E
Site 54
Y505
L
T
A
A
H
T
L
Y
P
K
E
H
E
A
Q
Site 55
S513
P
K
E
H
E
A
Q
S
N
A
S
L
D
V
F
Site 56
S516
H
E
A
Q
S
N
A
S
L
D
V
F
L
G
H
Site 57
S541
N
H
P
I
R
R
V
S
V
H
P
D
Y
R
Q
Site 58
Y546
R
V
S
V
H
P
D
Y
R
Q
D
E
S
Y
N
Site 59
S551
P
D
Y
R
Q
D
E
S
Y
N
F
E
G
D
I
Site 60
Y552
D
Y
R
Q
D
E
S
Y
N
F
E
G
D
I
A
Site 61
Y585
L
P
D
N
D
T
F
Y
D
L
G
L
M
G
Y
Site 62
T665
F
A
V
R
D
P
N
T
D
R
W
V
A
T
G
Site 63
Y684
G
I
G
C
S
R
G
Y
G
F
Y
T
K
V
L
Site 64
Y687
C
S
R
G
Y
G
F
Y
T
K
V
L
N
Y
V
Site 65
Y693
F
Y
T
K
V
L
N
Y
V
D
W
I
K
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation