PhosphoNET

           
Protein Info 
   
Short Name:  PTTG1
Full Name:  Securin
Alias:  EAP1; ESP1-associated protein 1; HPTTG; Pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTG; Tumor-transforming protein 1; TUTR1
Type:  Cell cycle regulation
Mass (Da):  22024
Number AA:  202
UniProt ID:  O95997
International Prot ID:  IPI00003494
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0005634   Uniprot OncoNet
Molecular Function:  GO:0017124  GO:0004869  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0006281  GO:0051301  GO:0051276 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T16KENGEPGTRVVAKDG
Site 2S28KDGLKLGSGPSIKAL
Site 3S31LKLGSGPSIKALDGR
Site 4S39IKALDGRSQVSTPRF
Site 5S42LDGRSQVSTPRFGKT
Site 6T43DGRSQVSTPRFGKTF
Site 7T49STPRFGKTFDAPPAL
Site 8T66ATRKALGTVNRATEK
Site 9T71LGTVNRATEKSVKTK
Site 10S74VNRATEKSVKTKGPL
Site 11S87PLKQKQPSFSAKKMT
Site 12T97AKKMTEKTVKAKSSV
Site 13S102EKTVKAKSSVPASDD
Site 14S103KTVKAKSSVPASDDA
Site 15S107AKSSVPASDDAYPEI
Site 16Y111VPASDDAYPEIEKFF
Site 17S127FNPLDFESFDLPEEH
Site 18S165LFQLGPPSPVKMPSP
Site 19S171PSPVKMPSPPWESNL
Site 20S176MPSPPWESNLLQSPS
Site 21S181WESNLLQSPSSILST
Site 22S183SNLLQSPSSILSTLD
Site 23S184NLLQSPSSILSTLDV
Site 24S187QSPSSILSTLDVELP
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation