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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYST2
Full Name:
Histone acetyltransferase MYST2
Alias:
HBO1; HBOA; KAT7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2
Type:
Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator; EC 2.3.1.48
Mass (Da):
70642
Number AA:
611
UniProt ID:
O95251
International Prot ID:
IPI00180764
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000123
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0004402
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0043966
GO:0043983
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
R
K
R
N
A
G
S
S
S
D
G
T
E
D
Site 2
S11
R
K
R
N
A
G
S
S
S
D
G
T
E
D
S
Site 3
S12
K
R
N
A
G
S
S
S
D
G
T
E
D
S
D
Site 4
T15
A
G
S
S
S
D
G
T
E
D
S
D
F
S
T
Site 5
S18
S
S
D
G
T
E
D
S
D
F
S
T
D
L
E
Site 6
T22
T
E
D
S
D
F
S
T
D
L
E
H
T
D
S
Site 7
S29
T
D
L
E
H
T
D
S
S
E
S
D
G
T
S
Site 8
S30
D
L
E
H
T
D
S
S
E
S
D
G
T
S
R
Site 9
S32
E
H
T
D
S
S
E
S
D
G
T
S
R
R
S
Site 10
T35
D
S
S
E
S
D
G
T
S
R
R
S
A
R
V
Site 11
S36
S
S
E
S
D
G
T
S
R
R
S
A
R
V
T
Site 12
S39
S
D
G
T
S
R
R
S
A
R
V
T
R
S
S
Site 13
T43
S
R
R
S
A
R
V
T
R
S
S
A
R
L
S
Site 14
S45
R
S
A
R
V
T
R
S
S
A
R
L
S
Q
S
Site 15
S46
S
A
R
V
T
R
S
S
A
R
L
S
Q
S
S
Site 16
S50
T
R
S
S
A
R
L
S
Q
S
S
Q
D
S
S
Site 17
S52
S
S
A
R
L
S
Q
S
S
Q
D
S
S
P
V
Site 18
S53
S
A
R
L
S
Q
S
S
Q
D
S
S
P
V
R
Site 19
S56
L
S
Q
S
S
Q
D
S
S
P
V
R
N
L
Q
Site 20
S57
S
Q
S
S
Q
D
S
S
P
V
R
N
L
Q
S
Site 21
S64
S
P
V
R
N
L
Q
S
F
G
T
E
E
P
A
Site 22
T67
R
N
L
Q
S
F
G
T
E
E
P
A
Y
S
T
Site 23
Y72
F
G
T
E
E
P
A
Y
S
T
R
R
V
T
R
Site 24
S73
G
T
E
E
P
A
Y
S
T
R
R
V
T
R
S
Site 25
T78
A
Y
S
T
R
R
V
T
R
S
Q
Q
Q
P
T
Site 26
S80
S
T
R
R
V
T
R
S
Q
Q
Q
P
T
P
V
Site 27
T85
T
R
S
Q
Q
Q
P
T
P
V
T
P
K
K
Y
Site 28
T88
Q
Q
Q
P
T
P
V
T
P
K
K
Y
P
L
R
Site 29
Y92
T
P
V
T
P
K
K
Y
P
L
R
Q
T
R
S
Site 30
T97
K
K
Y
P
L
R
Q
T
R
S
S
G
S
E
T
Site 31
S99
Y
P
L
R
Q
T
R
S
S
G
S
E
T
E
Q
Site 32
S100
P
L
R
Q
T
R
S
S
G
S
E
T
E
Q
V
Site 33
S102
R
Q
T
R
S
S
G
S
E
T
E
Q
V
V
D
Site 34
T104
T
R
S
S
G
S
E
T
E
Q
V
V
D
F
S
Site 35
S111
T
E
Q
V
V
D
F
S
D
R
E
T
K
N
T
Site 36
T115
V
D
F
S
D
R
E
T
K
N
T
A
D
H
D
Site 37
T118
S
D
R
E
T
K
N
T
A
D
H
D
E
S
P
Site 38
S124
N
T
A
D
H
D
E
S
P
P
R
T
P
T
G
Site 39
T128
H
D
E
S
P
P
R
T
P
T
G
N
A
P
S
Site 40
T130
E
S
P
P
R
T
P
T
G
N
A
P
S
S
E
Site 41
S135
T
P
T
G
N
A
P
S
S
E
S
D
I
D
I
Site 42
S136
P
T
G
N
A
P
S
S
E
S
D
I
D
I
S
Site 43
S138
G
N
A
P
S
S
E
S
D
I
D
I
S
S
P
Site 44
S143
S
E
S
D
I
D
I
S
S
P
N
V
S
H
D
Site 45
S144
E
S
D
I
D
I
S
S
P
N
V
S
H
D
E
Site 46
S148
D
I
S
S
P
N
V
S
H
D
E
S
I
A
K
Site 47
S152
P
N
V
S
H
D
E
S
I
A
K
D
M
S
L
Site 48
S158
E
S
I
A
K
D
M
S
L
K
D
S
G
S
D
Site 49
S162
K
D
M
S
L
K
D
S
G
S
D
L
S
H
R
Site 50
S164
M
S
L
K
D
S
G
S
D
L
S
H
R
P
K
Site 51
S167
K
D
S
G
S
D
L
S
H
R
P
K
R
R
R
Site 52
S178
K
R
R
R
F
H
E
S
Y
N
F
N
M
K
C
Site 53
Y179
R
R
R
F
H
E
S
Y
N
F
N
M
K
C
P
Site 54
T187
N
F
N
M
K
C
P
T
P
G
C
N
S
L
G
Site 55
S192
C
P
T
P
G
C
N
S
L
G
H
L
T
G
K
Site 56
S205
G
K
H
E
R
H
F
S
I
S
G
C
P
L
Y
Site 57
Y212
S
I
S
G
C
P
L
Y
H
N
L
S
A
D
E
Site 58
S216
C
P
L
Y
H
N
L
S
A
D
E
C
K
V
R
Site 59
S226
E
C
K
V
R
A
Q
S
R
D
K
Q
I
E
E
Site 60
S237
Q
I
E
E
R
M
L
S
H
R
Q
D
D
N
N
Site 61
T248
D
D
N
N
R
H
A
T
R
H
Q
A
P
T
E
Site 62
T254
A
T
R
H
Q
A
P
T
E
R
Q
L
R
Y
K
Site 63
S273
E
L
R
K
K
R
N
S
G
L
S
K
E
Q
K
Site 64
S276
K
K
R
N
S
G
L
S
K
E
Q
K
E
K
Y
Site 65
Y283
S
K
E
Q
K
E
K
Y
M
E
H
R
Q
T
Y
Site 66
T289
K
Y
M
E
H
R
Q
T
Y
G
N
T
R
E
P
Site 67
Y290
Y
M
E
H
R
Q
T
Y
G
N
T
R
E
P
L
Site 68
S303
P
L
L
E
N
L
T
S
E
Y
D
L
D
L
F
Site 69
S318
R
R
A
Q
A
R
A
S
E
D
L
E
K
L
R
Site 70
T331
L
R
L
Q
G
Q
I
T
E
G
S
N
M
I
K
Site 71
S334
Q
G
Q
I
T
E
G
S
N
M
I
K
T
I
A
Site 72
T339
E
G
S
N
M
I
K
T
I
A
F
G
R
Y
E
Site 73
Y351
R
Y
E
L
D
T
W
Y
H
S
P
Y
P
E
E
Site 74
S353
E
L
D
T
W
Y
H
S
P
Y
P
E
E
Y
A
Site 75
Y355
D
T
W
Y
H
S
P
Y
P
E
E
Y
A
R
L
Site 76
Y359
H
S
P
Y
P
E
E
Y
A
R
L
G
R
L
Y
Site 77
Y399
H
P
P
G
D
E
I
Y
R
K
G
S
I
S
V
Site 78
S403
D
E
I
Y
R
K
G
S
I
S
V
F
E
V
D
Site 79
S405
I
Y
R
K
G
S
I
S
V
F
E
V
D
G
K
Site 80
Y417
D
G
K
K
N
K
I
Y
C
Q
N
L
C
L
L
Site 81
T433
K
L
F
L
D
H
K
T
L
Y
Y
D
V
E
P
Site 82
Y435
F
L
D
H
K
T
L
Y
Y
D
V
E
P
F
L
Site 83
Y436
L
D
H
K
T
L
Y
Y
D
V
E
P
F
L
F
Site 84
Y444
D
V
E
P
F
L
F
Y
V
M
T
E
A
D
N
Site 85
Y459
T
G
C
H
L
I
G
Y
F
S
K
E
K
N
S
Site 86
S466
Y
F
S
K
E
K
N
S
F
L
N
Y
N
V
S
Site 87
Y470
E
K
N
S
F
L
N
Y
N
V
S
C
I
L
T
Site 88
Y481
C
I
L
T
M
P
Q
Y
M
R
Q
G
Y
G
K
Site 89
Y486
P
Q
Y
M
R
Q
G
Y
G
K
M
L
I
D
F
Site 90
S498
I
D
F
S
Y
L
L
S
K
V
E
E
K
V
G
Site 91
S506
K
V
E
E
K
V
G
S
P
E
R
P
L
S
D
Site 92
S512
G
S
P
E
R
P
L
S
D
L
G
L
I
S
Y
Site 93
S518
L
S
D
L
G
L
I
S
Y
R
S
Y
W
K
E
Site 94
Y519
S
D
L
G
L
I
S
Y
R
S
Y
W
K
E
V
Site 95
Y522
G
L
I
S
Y
R
S
Y
W
K
E
V
L
L
R
Site 96
Y530
W
K
E
V
L
L
R
Y
L
H
N
F
Q
G
K
Site 97
S540
N
F
Q
G
K
E
I
S
I
K
E
I
S
Q
E
Site 98
S545
E
I
S
I
K
E
I
S
Q
E
T
A
V
N
P
Site 99
Y567
Q
A
L
Q
M
L
K
Y
W
K
G
K
H
L
V
Site 100
S592
I
A
K
E
A
K
R
S
N
S
N
K
T
M
D
Site 101
S594
K
E
A
K
R
S
N
S
N
K
T
M
D
P
S
Site 102
T597
K
R
S
N
S
N
K
T
M
D
P
S
C
L
K
Site 103
S601
S
N
K
T
M
D
P
S
C
L
K
W
T
P
P
Site 104
T606
D
P
S
C
L
K
W
T
P
P
K
G
T
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation