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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF4A
Full Name:
Chromosome-associated kinesin KIF4A
Alias:
Chromokinesin; Chromokinesin-A; FLJ12530; FLJ12655; FLJ14204; FLJ20631; HSA271784; KIF4; KIF4-G1; Kinesin family member 4; Kinesin family member 4A
Type:
Microtubule binding protein; Motor protein
Mass (Da):
139881
Number AA:
1232
UniProt ID:
O95239
International Prot ID:
IPI00178150
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016363
GO:0005876
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0008089
GO:0006996
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
E
G
C
Q
M
C
L
S
F
V
P
G
E
P
Q
Site 2
Y51
G
T
D
K
S
F
T
Y
D
F
V
F
D
P
S
Site 3
S58
Y
D
F
V
F
D
P
S
T
E
Q
E
E
V
F
Site 4
T59
D
F
V
F
D
P
S
T
E
Q
E
E
V
F
N
Site 5
T67
E
Q
E
E
V
F
N
T
A
V
A
P
L
I
K
Site 6
S92
L
A
Y
G
Q
T
G
S
G
K
T
Y
S
M
G
Site 7
T95
G
Q
T
G
S
G
K
T
Y
S
M
G
G
A
Y
Site 8
Y96
Q
T
G
S
G
K
T
Y
S
M
G
G
A
Y
T
Site 9
S97
T
G
S
G
K
T
Y
S
M
G
G
A
Y
T
A
Site 10
T111
A
E
Q
E
N
E
P
T
V
G
V
I
P
R
V
Site 11
S130
F
K
E
I
D
K
K
S
D
F
E
F
T
L
K
Site 12
T135
K
K
S
D
F
E
F
T
L
K
V
S
Y
L
E
Site 13
Y144
K
V
S
Y
L
E
I
Y
N
E
E
I
L
D
L
Site 14
T199
E
Q
G
N
N
S
R
T
V
A
S
T
A
M
N
Site 15
T203
N
S
R
T
V
A
S
T
A
M
N
S
Q
S
S
Site 16
S207
V
A
S
T
A
M
N
S
Q
S
S
R
S
H
A
Site 17
S209
S
T
A
M
N
S
Q
S
S
R
S
H
A
I
F
Site 18
S219
S
H
A
I
F
T
I
S
L
E
Q
R
K
K
S
Site 19
S226
S
L
E
Q
R
K
K
S
D
K
N
S
S
F
R
Site 20
S230
R
K
K
S
D
K
N
S
S
F
R
S
K
L
H
Site 21
S231
K
K
S
D
K
N
S
S
F
R
S
K
L
H
L
Site 22
S234
D
K
N
S
S
F
R
S
K
L
H
L
V
D
L
Site 23
S244
H
L
V
D
L
A
G
S
E
R
Q
K
K
T
K
Site 24
Y288
K
K
G
G
F
V
P
Y
R
D
S
K
L
T
R
Site 25
S291
G
F
V
P
Y
R
D
S
K
L
T
R
L
L
Q
Site 26
T294
P
Y
R
D
S
K
L
T
R
L
L
Q
D
S
L
Site 27
S300
L
T
R
L
L
Q
D
S
L
G
G
N
S
H
T
Site 28
S318
A
C
V
S
P
A
D
S
N
L
E
E
T
L
N
Site 29
T326
N
L
E
E
T
L
N
T
L
R
Y
A
D
R
A
Site 30
T348
I
V
N
I
D
P
Q
T
A
E
L
N
H
L
K
Site 31
S376
H
G
G
T
L
P
G
S
I
T
V
E
P
S
E
Site 32
T378
G
T
L
P
G
S
I
T
V
E
P
S
E
N
L
Site 33
S382
G
S
I
T
V
E
P
S
E
N
L
Q
S
L
M
Site 34
S387
E
P
S
E
N
L
Q
S
L
M
E
K
N
Q
S
Site 35
S394
S
L
M
E
K
N
Q
S
L
V
E
E
N
E
K
Site 36
S407
E
K
L
S
R
G
L
S
E
A
A
G
Q
T
A
Site 37
T423
M
L
E
R
I
I
L
T
E
Q
A
N
E
K
M
Site 38
T474
C
N
L
Q
Q
L
I
T
Q
L
S
D
E
T
V
Site 39
S477
Q
Q
L
I
T
Q
L
S
D
E
T
V
A
C
M
Site 40
T480
I
T
Q
L
S
D
E
T
V
A
C
M
A
A
A
Site 41
T490
C
M
A
A
A
I
D
T
A
V
E
Q
E
A
Q
Site 42
T500
E
Q
E
A
Q
V
E
T
S
P
E
T
S
R
S
Site 43
S501
Q
E
A
Q
V
E
T
S
P
E
T
S
R
S
S
Site 44
T504
Q
V
E
T
S
P
E
T
S
R
S
S
D
A
F
Site 45
S505
V
E
T
S
P
E
T
S
R
S
S
D
A
F
T
Site 46
S507
T
S
P
E
T
S
R
S
S
D
A
F
T
T
Q
Site 47
S508
S
P
E
T
S
R
S
S
D
A
F
T
T
Q
H
Site 48
T512
S
R
S
S
D
A
F
T
T
Q
H
A
L
R
Q
Site 49
S523
A
L
R
Q
A
Q
M
S
K
E
L
V
E
L
N
Site 50
T544
E
A
L
A
R
K
M
T
Q
N
D
S
Q
L
Q
Site 51
S548
R
K
M
T
Q
N
D
S
Q
L
Q
P
I
Q
Y
Site 52
Y555
S
Q
L
Q
P
I
Q
Y
Q
Y
Q
D
N
I
K
Site 53
S595
D
A
N
Q
A
K
L
S
E
R
R
R
K
R
L
Site 54
S628
K
L
L
K
L
K
E
S
T
E
R
T
V
S
K
Site 55
T629
L
L
K
L
K
E
S
T
E
R
T
V
S
K
L
Site 56
T632
L
K
E
S
T
E
R
T
V
S
K
L
N
Q
E
Site 57
S634
E
S
T
E
R
T
V
S
K
L
N
Q
E
I
R
Site 58
Y684
E
R
D
R
K
R
Q
Y
E
L
L
K
L
E
R
Site 59
T704
S
N
V
L
R
R
K
T
E
E
A
A
A
A
N
Site 60
T731
V
A
D
K
R
K
E
T
Q
S
R
G
M
E
G
Site 61
S733
D
K
R
K
E
T
Q
S
R
G
M
E
G
T
A
Site 62
T739
Q
S
R
G
M
E
G
T
A
A
R
V
K
N
W
Site 63
S756
N
E
I
E
V
M
V
S
T
E
E
A
K
R
H
Site 64
S787
Q
L
K
E
K
K
E
S
G
E
N
P
P
P
K
Site 65
T799
P
P
K
L
R
R
R
T
F
S
L
T
E
V
R
Site 66
S801
K
L
R
R
R
T
F
S
L
T
E
V
R
G
Q
Site 67
T803
R
R
R
T
F
S
L
T
E
V
R
G
Q
V
S
Site 68
S810
T
E
V
R
G
Q
V
S
E
S
E
D
S
I
T
Site 69
S812
V
R
G
Q
V
S
E
S
E
D
S
I
T
K
Q
Site 70
S815
Q
V
S
E
S
E
D
S
I
T
K
Q
I
E
S
Site 71
T817
S
E
S
E
D
S
I
T
K
Q
I
E
S
L
E
Site 72
S822
S
I
T
K
Q
I
E
S
L
E
T
E
M
E
F
Site 73
T825
K
Q
I
E
S
L
E
T
E
M
E
F
R
S
A
Site 74
S846
Q
K
L
L
D
A
E
S
E
D
R
P
K
Q
R
Site 75
T859
Q
R
W
E
N
I
A
T
I
L
E
A
K
C
A
Site 76
Y869
E
A
K
C
A
L
K
Y
L
I
G
E
L
V
S
Site 77
S876
Y
L
I
G
E
L
V
S
S
K
I
Q
V
S
K
Site 78
S877
L
I
G
E
L
V
S
S
K
I
Q
V
S
K
L
Site 79
S882
V
S
S
K
I
Q
V
S
K
L
E
S
S
L
K
Site 80
S886
I
Q
V
S
K
L
E
S
S
L
K
Q
S
K
T
Site 81
S887
Q
V
S
K
L
E
S
S
L
K
Q
S
K
T
S
Site 82
S891
L
E
S
S
L
K
Q
S
K
T
S
C
A
D
M
Site 83
T893
S
S
L
K
Q
S
K
T
S
C
A
D
M
Q
K
Site 84
Y933
Q
H
Q
E
K
V
L
Y
L
L
S
Q
L
Q
Q
Site 85
S936
E
K
V
L
Y
L
L
S
Q
L
Q
Q
S
Q
M
Site 86
S941
L
L
S
Q
L
Q
Q
S
Q
M
A
E
K
Q
L
Site 87
S951
A
E
K
Q
L
E
E
S
V
S
E
K
E
Q
Q
Site 88
S953
K
Q
L
E
E
S
V
S
E
K
E
Q
Q
L
L
Site 89
T995
E
I
I
K
Q
K
L
T
L
L
Q
V
A
S
R
Site 90
S1001
L
T
L
L
Q
V
A
S
R
Q
K
H
L
P
K
Site 91
T1010
Q
K
H
L
P
K
D
T
L
L
S
P
D
S
S
Site 92
S1013
L
P
K
D
T
L
L
S
P
D
S
S
F
E
Y
Site 93
S1016
D
T
L
L
S
P
D
S
S
F
E
Y
V
P
P
Site 94
S1017
T
L
L
S
P
D
S
S
F
E
Y
V
P
P
K
Site 95
Y1020
S
P
D
S
S
F
E
Y
V
P
P
K
P
K
P
Site 96
S1028
V
P
P
K
P
K
P
S
R
V
K
E
K
F
L
Site 97
S1038
K
E
K
F
L
E
Q
S
M
D
I
E
D
L
K
Site 98
Y1046
M
D
I
E
D
L
K
Y
C
S
E
H
S
V
N
Site 99
S1048
I
E
D
L
K
Y
C
S
E
H
S
V
N
E
H
Site 100
S1051
L
K
Y
C
S
E
H
S
V
N
E
H
E
D
G
Site 101
T1073
D
D
E
E
W
K
P
T
K
L
V
K
V
S
R
Site 102
T1115
V
D
C
C
C
D
P
T
K
C
R
N
R
Q
Q
Site 103
S1126
N
R
Q
Q
G
K
D
S
L
G
T
V
E
R
T
Site 104
T1129
Q
G
K
D
S
L
G
T
V
E
R
T
Q
D
S
Site 105
T1133
S
L
G
T
V
E
R
T
Q
D
S
E
G
S
F
Site 106
S1136
T
V
E
R
T
Q
D
S
E
G
S
F
K
L
E
Site 107
S1139
R
T
Q
D
S
E
G
S
F
K
L
E
D
P
T
Site 108
T1146
S
F
K
L
E
D
P
T
E
V
T
P
G
L
S
Site 109
T1149
L
E
D
P
T
E
V
T
P
G
L
S
F
F
N
Site 110
T1161
F
F
N
P
V
C
A
T
P
N
S
K
I
L
K
Site 111
S1178
C
D
V
E
Q
V
L
S
K
K
T
P
P
A
P
Site 112
T1181
E
Q
V
L
S
K
K
T
P
P
A
P
S
P
F
Site 113
S1186
K
K
T
P
P
A
P
S
P
F
D
L
P
E
L
Site 114
Y1200
L
K
H
V
A
T
E
Y
Q
E
N
K
A
P
G
Site 115
S1216
K
K
K
R
A
L
A
S
N
T
S
F
F
S
G
Site 116
T1218
K
R
A
L
A
S
N
T
S
F
F
S
G
C
S
Site 117
S1219
R
A
L
A
S
N
T
S
F
F
S
G
C
S
P
Site 118
S1222
A
S
N
T
S
F
F
S
G
C
S
P
I
E
E
Site 119
S1225
T
S
F
F
S
G
C
S
P
I
E
E
E
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation