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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPN2
Full Name:
Epsin-2
Alias:
EHB21; Eps15 binding protein; EPS-15 interacting protein 2; Epsin 2; KIAA1065
Type:
Vesicle formation protein
Mass (Da):
68482
Number AA:
641
UniProt ID:
O95208
International Prot ID:
IPI00397381
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
M
K
N
I
V
N
N
Y
S
E
A
E
I
K
V
Site 2
T28
E
I
K
V
R
E
A
T
S
N
D
P
W
G
P
Site 3
S37
N
D
P
W
G
P
S
S
S
L
M
T
E
I
A
Site 4
S38
D
P
W
G
P
S
S
S
L
M
T
E
I
A
D
Site 5
T41
G
P
S
S
S
L
M
T
E
I
A
D
L
T
Y
Site 6
Y75
G
K
N
W
R
H
V
Y
K
A
L
T
L
L
D
Site 7
Y83
K
A
L
T
L
L
D
Y
L
I
K
T
G
S
E
Site 8
S89
D
Y
L
I
K
T
G
S
E
R
V
A
Q
Q
C
Site 9
Y111
Q
T
L
K
D
F
Q
Y
I
D
R
D
G
K
D
Site 10
T150
E
R
A
Q
A
L
K
T
K
E
R
M
A
Q
V
Site 11
S163
Q
V
A
T
G
M
G
S
N
Q
I
T
F
G
R
Site 12
T167
G
M
G
S
N
Q
I
T
F
G
R
G
S
S
Q
Site 13
S172
Q
I
T
F
G
R
G
S
S
Q
P
N
L
S
T
Site 14
S173
I
T
F
G
R
G
S
S
Q
P
N
L
S
T
S
Site 15
S178
G
S
S
Q
P
N
L
S
T
S
H
S
E
Q
E
Site 16
S180
S
Q
P
N
L
S
T
S
H
S
E
Q
E
Y
G
Site 17
S182
P
N
L
S
T
S
H
S
E
Q
E
Y
G
K
A
Site 18
Y186
T
S
H
S
E
Q
E
Y
G
K
A
G
G
S
P
Site 19
S192
E
Y
G
K
A
G
G
S
P
A
S
Y
H
G
S
Site 20
S195
K
A
G
G
S
P
A
S
Y
H
G
S
P
E
A
Site 21
Y196
A
G
G
S
P
A
S
Y
H
G
S
P
E
A
S
Site 22
S199
S
P
A
S
Y
H
G
S
P
E
A
S
L
C
P
Site 23
S203
Y
H
G
S
P
E
A
S
L
C
P
Q
H
R
T
Site 24
S224
S
E
E
L
Q
P
L
S
Q
R
H
P
F
L
P
Site 25
S237
L
P
H
L
G
L
A
S
R
P
N
G
D
W
S
Site 26
T257
C
D
R
A
A
R
A
T
S
P
R
V
S
S
E
Site 27
S258
D
R
A
A
R
A
T
S
P
R
V
S
S
E
L
Site 28
S262
R
A
T
S
P
R
V
S
S
E
L
E
Q
A
R
Site 29
S263
A
T
S
P
R
V
S
S
E
L
E
Q
A
R
P
Site 30
T272
L
E
Q
A
R
P
Q
T
S
G
E
E
E
L
Q
Site 31
S273
E
Q
A
R
P
Q
T
S
G
E
E
E
L
Q
L
Site 32
S287
L
Q
L
A
L
A
M
S
R
E
V
A
E
Q
E
Site 33
S312
L
Q
M
A
L
E
E
S
R
R
D
T
V
K
I
Site 34
T316
L
E
E
S
R
R
D
T
V
K
I
P
K
K
K
Site 35
S327
P
K
K
K
E
H
G
S
L
P
Q
Q
T
T
L
Site 36
T333
G
S
L
P
Q
Q
T
T
L
L
D
L
M
D
A
Site 37
S344
L
M
D
A
L
P
S
S
G
P
A
A
Q
K
A
Site 38
S359
E
P
W
G
P
S
A
S
T
N
Q
T
N
P
W
Site 39
T363
P
S
A
S
T
N
Q
T
N
P
W
G
G
P
A
Site 40
S374
G
G
P
A
A
P
A
S
T
S
D
P
W
P
S
Site 41
T375
G
P
A
A
P
A
S
T
S
D
P
W
P
S
F
Site 42
S376
P
A
A
P
A
S
T
S
D
P
W
P
S
F
G
Site 43
S381
S
T
S
D
P
W
P
S
F
G
T
K
P
A
A
Site 44
S389
F
G
T
K
P
A
A
S
I
D
P
W
G
V
P
Site 45
S403
P
T
G
A
T
V
Q
S
V
P
K
N
S
D
P
Site 46
S408
V
Q
S
V
P
K
N
S
D
P
W
A
A
S
Q
Site 47
S414
N
S
D
P
W
A
A
S
Q
Q
P
A
S
S
A
Site 48
S419
A
A
S
Q
Q
P
A
S
S
A
G
K
R
A
S
Site 49
S420
A
S
Q
Q
P
A
S
S
A
G
K
R
A
S
D
Site 50
S426
S
S
A
G
K
R
A
S
D
A
W
G
A
V
S
Site 51
S433
S
D
A
W
G
A
V
S
T
T
K
P
V
S
V
Site 52
S448
S
G
S
F
E
L
F
S
N
L
N
G
T
I
K
Site 53
S459
G
T
I
K
D
D
F
S
E
F
D
N
L
R
T
Site 54
S467
E
F
D
N
L
R
T
S
K
K
T
A
E
S
V
Site 55
T470
N
L
R
T
S
K
K
T
A
E
S
V
T
S
L
Site 56
S473
T
S
K
K
T
A
E
S
V
T
S
L
P
S
Q
Site 57
T475
K
K
T
A
E
S
V
T
S
L
P
S
Q
N
N
Site 58
S476
K
T
A
E
S
V
T
S
L
P
S
Q
N
N
G
Site 59
S479
E
S
V
T
S
L
P
S
Q
N
N
G
T
T
S
Site 60
T484
L
P
S
Q
N
N
G
T
T
S
P
D
P
F
E
Site 61
T485
P
S
Q
N
N
G
T
T
S
P
D
P
F
E
S
Site 62
S486
S
Q
N
N
G
T
T
S
P
D
P
F
E
S
Q
Site 63
S492
T
S
P
D
P
F
E
S
Q
P
L
T
V
A
S
Site 64
T496
P
F
E
S
Q
P
L
T
V
A
S
S
K
P
S
Site 65
S499
S
Q
P
L
T
V
A
S
S
K
P
S
S
A
R
Site 66
S500
Q
P
L
T
V
A
S
S
K
P
S
S
A
R
K
Site 67
S503
T
V
A
S
S
K
P
S
S
A
R
K
T
P
E
Site 68
S504
V
A
S
S
K
P
S
S
A
R
K
T
P
E
S
Site 69
T508
K
P
S
S
A
R
K
T
P
E
S
F
L
G
P
Site 70
S511
S
A
R
K
T
P
E
S
F
L
G
P
N
A
A
Site 71
S535
R
P
A
P
P
A
Q
S
L
N
P
F
L
A
P
Site 72
S548
A
P
G
A
P
A
T
S
A
P
V
N
P
F
Q
Site 73
T563
V
N
Q
P
Q
P
L
T
L
N
Q
L
R
G
S
Site 74
S570
T
L
N
Q
L
R
G
S
P
V
L
G
T
S
T
Site 75
T575
R
G
S
P
V
L
G
T
S
T
S
F
G
P
G
Site 76
S576
G
S
P
V
L
G
T
S
T
S
F
G
P
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation