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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STK10
Full Name:
Serine/threonine-protein kinase 10
Alias:
EC 2.7.11.1; GEK2; Lymphocyte-oriented kinase
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; SLK subfamily
Mass (Da):
112135
Number AA:
968
UniProt ID:
O94804
International Prot ID:
IPI00783394
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Lymphocyte-oriented protein-serine kinase; Serine-threonine-protein kinase 10 S191 phosphosite-specific antibody AB-PK685#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK685#Lymphocyte-oriented protein-serine kinase; Serine-threonine-protein kinase 10 T952 phosphosite-specific antibody AB-PK686#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK686#IRS1 (979-989) KinSub - Insulin receptor substrate 1 (K979-G989, mouse) peptide; Insulin receptor substrate - Powder PE-01ADC95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADC95#Lymphocyte-oriented protein-serine kinase / Serine-threonine-protein kinase 10 (K188-G194, human) pS191 phosphopeptide - Powder PE-04AKO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKO99#Lymphocyte-oriented protein-serine kinase / Serine-threonine-protein kinase 10 (N949-K955, human) pT952 phosphopeptide - Powder PE-04ANM95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANM95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
F
R
R
I
L
R
L
S
T
F
E
K
R
K
S
Site 2
T14
R
R
I
L
R
L
S
T
F
E
K
R
K
S
R
Site 3
S20
S
T
F
E
K
R
K
S
R
E
Y
E
H
V
R
Site 4
Y23
E
K
R
K
S
R
E
Y
E
H
V
R
R
D
L
Site 5
Y51
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
Site 6
S71
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
Site 7
Y78
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
Site 8
T130
L
E
L
D
R
G
L
T
E
P
Q
I
Q
V
V
Site 9
S150
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
Site 10
T185
V
S
A
K
N
L
K
T
L
Q
K
R
D
S
F
Site 11
S191
K
T
L
Q
K
R
D
S
F
I
G
T
P
Y
W
Lymphocyte-oriented protein-serine kinase; Serine-threonine-protein kinase 10 S191 phosphosite-specific antibody AB-PK685#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK685#Lymphocyte-oriented protein-serine kinase / Serine-threonine-protein kinase 10 (K188-G194, human) pS191 phosphopeptide - Powder PE-04AKO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AKO99
Site 12
T195
K
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
Site 13
Y197
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
Site 14
T208
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Site 15
Y214
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
Site 16
Y216
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
Site 17
T256
I
A
K
S
D
P
P
T
L
L
T
P
S
K
W
Site 18
T259
S
D
P
P
T
L
L
T
P
S
K
W
S
V
E
Site 19
S284
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
Site 20
S299
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
Site 21
T341
A
S
T
L
E
N
H
T
Q
N
S
S
E
V
S
Site 22
S344
L
E
N
H
T
Q
N
S
S
E
V
S
P
P
S
Site 23
S345
E
N
H
T
Q
N
S
S
E
V
S
P
P
S
L
Site 24
S348
T
Q
N
S
S
E
V
S
P
P
S
L
N
A
D
Site 25
S351
S
S
E
V
S
P
P
S
L
N
A
D
K
P
L
Site 26
S361
A
D
K
P
L
E
E
S
P
S
T
P
L
A
P
Site 27
S363
K
P
L
E
E
S
P
S
T
P
L
A
P
S
Q
Site 28
T364
P
L
E
E
S
P
S
T
P
L
A
P
S
Q
S
Site 29
S369
P
S
T
P
L
A
P
S
Q
S
Q
D
S
V
N
Site 30
S371
T
P
L
A
P
S
Q
S
Q
D
S
V
N
E
P
Site 31
S374
A
P
S
Q
S
Q
D
S
V
N
E
P
C
S
Q
Site 32
S380
D
S
V
N
E
P
C
S
Q
P
S
G
D
R
S
Site 33
S383
N
E
P
C
S
Q
P
S
G
D
R
S
L
Q
T
Site 34
S387
S
Q
P
S
G
D
R
S
L
Q
T
T
S
P
P
Site 35
T390
S
G
D
R
S
L
Q
T
T
S
P
P
V
V
A
Site 36
T391
G
D
R
S
L
Q
T
T
S
P
P
V
V
A
P
Site 37
S392
D
R
S
L
Q
T
T
S
P
P
V
V
A
P
G
Site 38
S413
V
P
V
P
L
R
K
S
R
P
V
S
M
D
A
Site 39
S417
L
R
K
S
R
P
V
S
M
D
A
R
I
Q
V
Site 40
S438
A
E
Q
G
G
D
L
S
P
A
A
N
R
S
Q
Site 41
S444
L
S
P
A
A
N
R
S
Q
K
A
S
Q
S
R
Site 42
S448
A
N
R
S
Q
K
A
S
Q
S
R
P
N
S
S
Site 43
S450
R
S
Q
K
A
S
Q
S
R
P
N
S
S
A
L
Site 44
S454
A
S
Q
S
R
P
N
S
S
A
L
E
T
L
G
Site 45
S455
S
Q
S
R
P
N
S
S
A
L
E
T
L
G
G
Site 46
T459
P
N
S
S
A
L
E
T
L
G
G
E
K
L
A
Site 47
S469
G
E
K
L
A
N
G
S
L
E
P
P
A
Q
A
Site 48
S481
A
Q
A
A
P
G
P
S
K
R
D
S
D
C
S
Site 49
S485
P
G
P
S
K
R
D
S
D
C
S
S
L
C
T
Site 50
S488
S
K
R
D
S
D
C
S
S
L
C
T
S
E
S
Site 51
S489
K
R
D
S
D
C
S
S
L
C
T
S
E
S
M
Site 52
T492
S
D
C
S
S
L
C
T
S
E
S
M
D
Y
G
Site 53
S493
D
C
S
S
L
C
T
S
E
S
M
D
Y
G
T
Site 54
S495
S
S
L
C
T
S
E
S
M
D
Y
G
T
N
L
Site 55
Y498
C
T
S
E
S
M
D
Y
G
T
N
L
S
T
D
Site 56
T500
S
E
S
M
D
Y
G
T
N
L
S
T
D
L
S
Site 57
S503
M
D
Y
G
T
N
L
S
T
D
L
S
L
N
K
Site 58
S507
T
N
L
S
T
D
L
S
L
N
K
E
M
G
S
Site 59
S514
S
L
N
K
E
M
G
S
L
S
I
K
D
P
K
Site 60
S516
N
K
E
M
G
S
L
S
I
K
D
P
K
L
Y
Site 61
T526
D
P
K
L
Y
K
K
T
L
K
R
T
R
K
F
Site 62
T530
Y
K
K
T
L
K
R
T
R
K
F
V
V
D
G
Site 63
S545
V
E
V
S
I
T
T
S
K
I
I
S
E
D
E
Site 64
S549
I
T
T
S
K
I
I
S
E
D
E
K
K
D
E
Site 65
T581
K
E
E
H
R
N
Q
T
Q
L
S
N
K
H
E
Site 66
T611
A
K
K
K
F
F
D
T
E
L
E
N
L
E
R
Site 67
Y650
R
L
E
Q
D
R
D
Y
T
R
F
Q
E
Q
L
Site 68
T651
L
E
Q
D
R
D
Y
T
R
F
Q
E
Q
L
K
Site 69
S679
P
R
Q
Q
R
K
E
S
M
K
Q
K
M
E
E
Site 70
T714
E
L
A
M
K
R
L
T
T
D
N
R
R
E
I
Site 71
T715
L
A
M
K
R
L
T
T
D
N
R
R
E
I
C
Site 72
Y766
K
Q
Q
L
K
D
Q
Y
F
L
Q
R
H
E
L
Site 73
Y787
E
R
E
Q
M
Q
R
Y
N
Q
R
M
I
E
Q
Site 74
T816
I
Q
R
S
E
G
K
T
R
M
A
M
Y
K
K
Site 75
S832
L
H
I
N
G
G
G
S
A
A
E
Q
R
E
K
Site 76
S844
R
E
K
I
K
Q
F
S
Q
Q
E
E
K
R
Q
Site 77
S853
Q
E
E
K
R
Q
K
S
E
R
L
Q
Q
Q
Q
Site 78
S875
D
M
L
A
Q
C
E
S
N
M
S
E
L
Q
Q
Site 79
S878
A
Q
C
E
S
N
M
S
E
L
Q
Q
L
Q
N
Site 80
S951
E
A
E
C
P
N
P
S
T
P
S
K
A
A
K
Site 81
T952
A
E
C
P
N
P
S
T
P
S
K
A
A
K
F
Lymphocyte-oriented protein-serine kinase; Serine-threonine-protein kinase 10 T952 phosphosite-specific antibody AB-PK686#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK686#Lymphocyte-oriented protein-serine kinase / Serine-threonine-protein kinase 10 (N949-K955, human) pT952 phosphopeptide - Powder PE-04ANM95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANM95
Site 82
S954
C
P
N
P
S
T
P
S
K
A
A
K
F
F
P
Site 83
S963
A
A
K
F
F
P
Y
S
S
A
D
A
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation