PhosphoNET

           
Protein Info 
   
Short Name:  PIAS1
Full Name:  E3 SUMO-protein ligase PIAS1
Alias:  AR interacting protein; DDXBP1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; GBP; GU/RH-II; Gu-binding protein; Protein inhibitor of activated STAT protein 1; Protein inhibitor of activated STAT, 1; Protein inhibitor of activated STAT-1; RNA helicase II-binding protein; Zinc finger, MIZ-type containing 3; ZMIZ3
Type:  SUMO conjugating system; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):  71836
Number AA:  651
UniProt ID:  O75925
International Prot ID:  IPI00220424
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016607     Uniprot OncoNet
Molecular Function:  GO:0003677  GO:0019789  GO:0050681 PhosphoSite+ KinaseNET
Biological Process:  GO:0007259  GO:0030521  GO:0019941 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S13ELKQMVMSLRVSELQ
Site 2Y25ELQVLLGYAGRNKHG
Site 3Y61QMKIKELYRRRFPQK
Site 4T71RFPQKIMTPADLSIP
Site 5S83SIPNVHSSPMPATLS
Site 6T88HSSPMPATLSPSTIP
Site 7S90SPMPATLSPSTIPQL
Site 8T93PATLSPSTIPQLTYD
Site 9T98PSTIPQLTYDGHPAS
Site 10S105TYDGHPASSPLLPVS
Site 11S106YDGHPASSPLLPVSL
Site 12S112SSPLLPVSLLGPKHE
Site 13Y144KLQKLPFYDLLDELI
Site 14S155DELIKPTSLASDNSQ
Site 15S158IKPTSLASDNSQRFR
Site 16S161TSLASDNSQRFRETC
Site 17T167NSQRFRETCFAFALT
Site 18S182PQQVQQISSSMDISG
Site 19S183QQVQQISSSMDISGT
Site 20S184QVQQISSSMDISGTK
Site 21S188ISSSMDISGTKCDFT
Site 22T190SSMDISGTKCDFTVQ
Site 23T195SGTKCDFTVQVQLRF
Site 24S205VQLRFCLSETSCPQE
Site 25T207LRFCLSETSCPQEDH
Site 26T225NLCVKVNTKPCSLPG
Site 27S229KVNTKPCSLPGYLPP
Site 28Y233KPCSLPGYLPPTKNG
Site 29T237LPGYLPPTKNGVEPK
Site 30S247GVEPKRPSRPINITS
Site 31T253PSRPINITSLVRLST
Site 32S254SRPINITSLVRLSTT
Site 33Y283RNYSMAVYLVKQLSS
Site 34S289VYLVKQLSSTVLLQR
Site 35S290YLVKQLSSTVLLQRL
Site 36T291LVKQLSSTVLLQRLR
Site 37S308GIRNPDHSRALIKEK
Site 38S322KLTADPDSEIATTSL
Site 39T326DPDSEIATTSLRVSL
Site 40Y362QCFDATLYIQMNEKK
Site 41T412IQFKEDGTWAPMRSK
Site 42S428EVQEVSASYNGVDGC
Site 43S446TLEHQVASHHQSSNK
Site 44S450QVASHHQSSNKNKKV
Site 45T463KVEVIDLTIDSSSDE
Site 46S466VIDLTIDSSSDEEEE
Site 47S467IDLTIDSSSDEEEEE
Site 48S468DLTIDSSSDEEEEEP
Site 49S476DEEEEEPSAKRTCPS
Site 50T480EEPSAKRTCPSLSPT
Site 51S483SAKRTCPSLSPTSPL
Site 52S485KRTCPSLSPTSPLNN
Site 53T487TCPSLSPTSPLNNKG
Site 54S488CPSLSPTSPLNNKGI
Site 55S497LNNKGILSLPHQASP
Site 56S503LSLPHQASPVSRTPS
Site 57S506PHQASPVSRTPSLPA
Site 58T508QASPVSRTPSLPAVD
Site 59S510SPVSRTPSLPAVDTS
Site 60T516PSLPAVDTSYINTSL
Site 61S522DTSYINTSLIQDYRH
Site 62Y527NTSLIQDYRHPFHMT
Site 63Y538FHMTPMPYDLQGLDF
Site 64Y556LSGDNQHYNTSLLAA
Site 65S577DDQDLLHSSRFFPYT
Site 66Y583HSSRFFPYTSSQMFL
Site 67T584SSRFFPYTSSQMFLD
Site 68S585SRFFPYTSSQMFLDQ
Site 69S586RFFPYTSSQMFLDQL
Site 70S598DQLSAGGSTSLPTTN
Site 71S600LSAGGSTSLPTTNGS
Site 72T603GGSTSLPTTNGSSSG
Site 73T604GSTSLPTTNGSSSGS
Site 74S607SLPTTNGSSSGSNSS
Site 75S608LPTTNGSSSGSNSSL
Site 76S609PTTNGSSSGSNSSLV
Site 77S611TNGSSSGSNSSLVSS
Site 78S613GSSSGSNSSLVSSNS
Site 79S614SSSGSNSSLVSSNSL
Site 80S617GSNSSLVSSNSLRES
Site 81S618SNSSLVSSNSLRESH
Site 82S620SSLVSSNSLRESHSH
Site 83S624SSNSLRESHSHTVTN
Site 84S626NSLRESHSHTVTNRS
Site 85T628LRESHSHTVTNRSST
Site 86T630ESHSHTVTNRSSTDT
Site 87S633SHTVTNRSSTDTASI
Site 88S634HTVTNRSSTDTASIF
Site 89T635TVTNRSSTDTASIFG
Site 90T637TNRSSTDTASIFGII
Site 91S639RSSTDTASIFGIIPD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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