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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GABBR2
Full Name:
Gamma-aminobutyric acid type B receptor subunit 2
Alias:
G protein-coupled receptor 51; GABA(B)R2; GABA-B receptor 2; GABABR2; GABA-B-R2; GABR2; Gamma-aminobutyric acid (GABA) B receptor, 2; Gamma-aminobutyric acid type B receptor, subunit 2 precursor; Gb2; GPR 51; GPR51; GPRC3B; G-protein coupled receptor 51; HG20
Type:
Channel protein
Mass (Da):
105821
Number AA:
941
UniProt ID:
O75899
International Prot ID:
IPI00027250
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005887
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0004965
PhosphoSite+
KinaseNET
Biological Process:
GO:0007194
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Gamma-aminobutyric acid type B receptor subunit 2 pan-specific antibody AB-NN256-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN256-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
P
R
S
S
G
Q
P
G
P
P
P
Site 2
S52
G
A
P
R
P
P
P
S
S
P
P
L
S
I
M
Site 3
S53
A
P
R
P
P
P
S
S
P
P
L
S
I
M
G
Site 4
S72
T
K
E
V
A
K
G
S
I
G
R
G
V
L
P
Site 5
S92
I
E
Q
I
R
N
E
S
L
L
R
P
Y
F
L
Site 6
Y97
N
E
S
L
L
R
P
Y
F
L
D
L
R
L
Y
Site 7
Y104
Y
F
L
D
L
R
L
Y
D
T
E
C
D
N
A
Site 8
T106
L
D
L
R
L
Y
D
T
E
C
D
N
A
K
G
Site 9
Y118
A
K
G
L
K
A
F
Y
D
A
I
K
Y
G
P
Site 10
Y169
V
L
A
D
K
K
K
Y
P
Y
F
F
R
T
V
Site 11
Y171
A
D
K
K
K
Y
P
Y
F
F
R
T
V
P
S
Site 12
T175
K
Y
P
Y
F
F
R
T
V
P
S
D
N
A
V
Site 13
S178
Y
F
F
R
T
V
P
S
D
N
A
V
N
P
A
Site 14
T200
Y
Q
W
K
R
V
G
T
L
T
Q
D
V
Q
R
Site 15
T202
W
K
R
V
G
T
L
T
Q
D
V
Q
R
F
S
Site 16
S209
T
Q
D
V
Q
R
F
S
E
V
R
N
D
L
T
Site 17
T216
S
E
V
R
N
D
L
T
G
V
L
Y
G
E
D
Site 18
Y220
N
D
L
T
G
V
L
Y
G
E
D
I
E
I
S
Site 19
S227
Y
G
E
D
I
E
I
S
D
T
E
S
F
S
N
Site 20
T229
E
D
I
E
I
S
D
T
E
S
F
S
N
D
P
Site 21
S231
I
E
I
S
D
T
E
S
F
S
N
D
P
C
T
Site 22
S233
I
S
D
T
E
S
F
S
N
D
P
C
T
S
V
Site 23
T238
S
F
S
N
D
P
C
T
S
V
K
K
L
K
G
Site 24
Y268
A
K
V
F
C
C
A
Y
E
E
N
M
Y
G
S
Site 25
Y273
C
A
Y
E
E
N
M
Y
G
S
K
Y
Q
W
I
Site 26
T295
S
W
W
E
Q
V
H
T
E
A
N
S
S
R
C
Site 27
S299
Q
V
H
T
E
A
N
S
S
R
C
L
R
K
N
Site 28
S323
G
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
Site 29
S324
V
D
F
E
P
L
S
S
K
Q
I
K
T
I
S
Site 30
T329
L
S
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Site 31
S331
S
K
Q
I
K
T
I
S
G
K
T
P
Q
Q
Y
Site 32
T334
I
K
T
I
S
G
K
T
P
Q
Q
Y
E
R
E
Site 33
Y338
S
G
K
T
P
Q
Q
Y
E
R
E
Y
N
N
K
Site 34
Y342
P
Q
Q
Y
E
R
E
Y
N
N
K
R
S
G
V
Site 35
S352
K
R
S
G
V
G
P
S
K
F
H
G
Y
A
Y
Site 36
Y357
G
P
S
K
F
H
G
Y
A
Y
D
G
I
W
V
Site 37
T375
T
L
Q
R
A
M
E
T
L
H
A
S
S
R
H
Site 38
S379
A
M
E
T
L
H
A
S
S
R
H
Q
R
I
Q
Site 39
Y390
Q
R
I
Q
D
F
N
Y
T
D
H
T
L
G
R
Site 40
T394
D
F
N
Y
T
D
H
T
L
G
R
I
I
L
N
Site 41
T425
R
N
G
E
R
M
G
T
I
K
F
T
Q
F
Q
Site 42
S434
K
F
T
Q
F
Q
D
S
R
E
V
K
V
G
E
Site 43
T455
T
L
E
I
I
N
D
T
I
R
F
Q
G
S
E
Site 44
T468
S
E
P
P
K
D
K
T
I
I
L
E
Q
L
R
Site 45
S516
Q
K
L
I
K
M
S
S
P
Y
M
N
N
L
I
Site 46
S545
G
L
D
G
S
F
V
S
E
K
T
F
E
T
L
Site 47
T551
V
S
E
K
T
F
E
T
L
C
T
V
R
T
W
Site 48
T624
A
V
D
P
L
R
R
T
V
E
K
Y
S
M
E
Site 49
Y628
L
R
R
T
V
E
K
Y
S
M
E
P
D
P
A
Site 50
S629
R
R
T
V
E
K
Y
S
M
E
P
D
P
A
G
Site 51
S640
D
P
A
G
R
D
I
S
I
R
P
L
L
E
H
Site 52
Y663
W
L
G
I
V
Y
A
Y
K
G
L
L
M
L
F
Site 53
S682
A
W
E
T
R
N
V
S
I
P
A
L
N
D
S
Site 54
Y691
P
A
L
N
D
S
K
Y
I
G
M
S
V
Y
N
Site 55
T755
R
T
N
P
D
A
A
T
Q
N
R
R
F
Q
F
Site 56
T763
Q
N
R
R
F
Q
F
T
Q
N
Q
K
K
E
D
Site 57
S771
Q
N
Q
K
K
E
D
S
K
T
S
T
S
V
T
Site 58
T773
Q
K
K
E
D
S
K
T
S
T
S
V
T
S
V
Site 59
S774
K
K
E
D
S
K
T
S
T
S
V
T
S
V
N
Site 60
T775
K
E
D
S
K
T
S
T
S
V
T
S
V
N
Q
Site 61
S776
E
D
S
K
T
S
T
S
V
T
S
V
N
Q
A
Site 62
T778
S
K
T
S
T
S
V
T
S
V
N
Q
A
S
T
Site 63
S784
V
T
S
V
N
Q
A
S
T
S
R
L
E
G
L
Site 64
S786
S
V
N
Q
A
S
T
S
R
L
E
G
L
Q
S
Site 65
S793
S
R
L
E
G
L
Q
S
E
N
H
R
L
R
M
Site 66
T819
V
T
M
Q
L
Q
D
T
P
E
K
T
T
Y
I
Site 67
Y825
D
T
P
E
K
T
T
Y
I
K
Q
N
H
Y
Q
Site 68
S846
N
L
G
N
F
T
E
S
T
D
G
G
K
A
I
Site 69
T868
N
P
Q
L
Q
W
N
T
T
E
P
S
R
T
C
Site 70
T869
P
Q
L
Q
W
N
T
T
E
P
S
R
T
C
K
Site 71
S884
D
P
I
E
D
I
N
S
P
E
H
I
Q
R
R
Site 72
S893
E
H
I
Q
R
R
L
S
L
Q
L
P
I
L
H
Site 73
S916
G
V
D
A
S
C
V
S
P
C
V
S
P
T
A
Site 74
S920
S
C
V
S
P
C
V
S
P
T
A
S
P
R
H
Site 75
T922
V
S
P
C
V
S
P
T
A
S
P
R
H
R
H
Site 76
S924
P
C
V
S
P
T
A
S
P
R
H
R
H
V
P
Site 77
S933
R
H
R
H
V
P
P
S
F
R
V
M
V
S
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation