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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPM1B
Full Name:
Protein phosphatase 1B
Alias:
PP2C-beta, PP2CB, Protein phosphatase 2C isoform beta
Type:
Protein-serine phosphatase
Mass (Da):
52643
Number AA:
479
UniProt ID:
O75688
International Prot ID:
IPI00026612
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008287
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0030145
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
A
F
L
D
K
P
K
T
E
K
H
N
A
H
G
Site 2
Y24
G
A
G
N
G
L
R
Y
G
L
S
S
M
Q
G
Site 3
S27
N
G
L
R
Y
G
L
S
S
M
Q
G
W
R
V
Site 4
S28
G
L
R
Y
G
L
S
S
M
Q
G
W
R
V
E
Site 5
Y59
D
W
S
F
F
A
V
Y
D
G
H
A
G
S
R
Site 6
Y70
A
G
S
R
V
A
N
Y
C
S
T
H
L
L
E
Site 7
T81
H
L
L
E
H
I
T
T
N
E
D
F
R
A
A
Site 8
S91
D
F
R
A
A
G
K
S
G
S
A
L
E
L
S
Site 9
S93
R
A
A
G
K
S
G
S
A
L
E
L
S
V
E
Site 10
S98
S
G
S
A
L
E
L
S
V
E
N
V
K
N
G
Site 11
Y116
G
F
L
K
I
D
E
Y
M
R
N
F
S
D
L
Site 12
S121
D
E
Y
M
R
N
F
S
D
L
R
N
G
M
D
Site 13
S130
L
R
N
G
M
D
R
S
G
S
T
A
V
G
V
Site 14
Y145
M
I
S
P
K
H
I
Y
F
I
N
C
G
D
S
Site 15
Y157
G
D
S
R
A
V
L
Y
R
N
G
Q
V
C
F
Site 16
S186
R
I
Q
N
A
G
G
S
V
M
I
Q
R
V
N
Site 17
S199
V
N
G
S
L
A
V
S
R
A
L
G
D
Y
D
Site 18
Y205
V
S
R
A
L
G
D
Y
D
Y
K
C
V
D
G
Site 19
Y207
R
A
L
G
D
Y
D
Y
K
C
V
D
G
K
G
Site 20
S221
G
P
T
E
Q
L
V
S
P
E
P
E
V
Y
E
Site 21
Y227
V
S
P
E
P
E
V
Y
E
I
L
R
A
E
E
Site 22
Y257
S
N
E
E
L
C
E
Y
V
K
S
R
L
E
V
Site 23
S260
E
L
C
E
Y
V
K
S
R
L
E
V
S
D
D
Site 24
S265
V
K
S
R
L
E
V
S
D
D
L
E
N
V
C
Site 25
S318
E
L
D
K
H
L
E
S
R
V
E
E
I
M
E
Site 26
S327
V
E
E
I
M
E
K
S
G
E
E
G
M
P
D
Site 27
Y367
R
N
V
I
E
A
V
Y
S
R
L
N
P
H
R
Site 28
S376
R
L
N
P
H
R
E
S
D
G
A
S
D
E
A
Site 29
S380
H
R
E
S
D
G
A
S
D
E
A
E
E
S
G
Site 30
S386
A
S
D
E
A
E
E
S
G
S
Q
G
K
L
V
Site 31
S388
D
E
A
E
E
S
G
S
Q
G
K
L
V
E
A
Site 32
Y407
R
I
N
H
R
G
N
Y
R
Q
L
L
E
E
M
Site 33
S428
A
K
V
E
G
E
E
S
P
A
E
P
A
A
T
Site 34
T435
S
P
A
E
P
A
A
T
A
T
S
S
N
S
D
Site 35
S439
P
A
A
T
A
T
S
S
N
S
D
A
G
N
P
Site 36
T448
S
D
A
G
N
P
V
T
M
Q
E
S
H
T
E
Site 37
S452
N
P
V
T
M
Q
E
S
H
T
E
S
E
S
G
Site 38
T454
V
T
M
Q
E
S
H
T
E
S
E
S
G
L
A
Site 39
S456
M
Q
E
S
H
T
E
S
E
S
G
L
A
E
L
Site 40
S465
S
G
L
A
E
L
D
S
S
N
E
D
A
G
T
Site 41
S466
G
L
A
E
L
D
S
S
N
E
D
A
G
T
K
Site 42
T472
S
S
N
E
D
A
G
T
K
M
S
G
E
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation