PhosphoNET

           
Protein Info 
   
Short Name:  LRP6
Full Name:  Low-density lipoprotein receptor-related protein 6
Alias:  LDL receptor-related protein 6; Low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6
Type:  Receptor, misc.
Mass (Da):  180443
Number AA:  1613
UniProt ID:  O75581
International Prot ID:  IPI00000203
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021  GO:0005886   Uniprot OncoNet
Molecular Function:  GO:0005041     PhosphoSite+ KinaseNET
Biological Process:  GO:0060070  GO:0006897   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y677DVTDNRIYWTDISLK
Site 2T1410KGDGETMTNDYVVHG
Site 3Y1413GETMTNDYVVHGPAS
Site 4S1420YVVHGPASVPLGYVP
Site 5S1430LGYVPHPSSLSGSLP
Site 6S1431GYVPHPSSLSGSLPG
Site 7S1433VPHPSSLSGSLPGMS
Site 8S1435HPSSLSGSLPGMSRG
Site 9S1440SGSLPGMSRGKSMIS
Site 10S1444PGMSRGKSMISSLSI
Site 11S1447SRGKSMISSLSIMGG
Site 12S1448RGKSMISSLSIMGGS
Site 13S1455SLSIMGGSSGPPYDR
Site 14S1456LSIMGGSSGPPYDRA
Site 15Y1460GGSSGPPYDRAHVTG
Site 16T1466PYDRAHVTGASSSSS
Site 17S1469RAHVTGASSSSSSST
Site 18S1470AHVTGASSSSSSSTK
Site 19S1471HVTGASSSSSSSTKG
Site 20S1472VTGASSSSSSSTKGT
Site 21S1473TGASSSSSSSTKGTY
Site 22S1474GASSSSSSSTKGTYF
Site 23S1475ASSSSSSSTKGTYFP
Site 24T1476SSSSSSSTKGTYFPA
Site 25T1479SSSSTKGTYFPAILN
Site 26Y1480SSSTKGTYFPAILNP
Site 27S1490AILNPPPSPATERSH
Site 28T1493NPPPSPATERSHYTM
Site 29S1496PSPATERSHYTMEFG
Site 30Y1498PATERSHYTMEFGYS
Site 31T1499ATERSHYTMEFGYSS
Site 32Y1504HYTMEFGYSSNSPST
Site 33S1505YTMEFGYSSNSPSTH
Site 34S1506TMEFGYSSNSPSTHR
Site 35S1508EFGYSSNSPSTHRSY
Site 36S1510GYSSNSPSTHRSYSY
Site 37T1511YSSNSPSTHRSYSYR
Site 38S1514NSPSTHRSYSYRPYS
Site 39Y1515SPSTHRSYSYRPYSY
Site 40S1516PSTHRSYSYRPYSYR
Site 41Y1517STHRSYSYRPYSYRH
Site 42Y1520RSYSYRPYSYRHFAP
Site 43S1521SYSYRPYSYRHFAPP
Site 44Y1522STHRSYSYRPYSYRH
Site 45T1529YRHFAPPTTPCSTDV
Site 46T1530RHFAPPTTPCSTDVC
Site 47S1533APPTTPCSTDVCDSD
Site 48Y1541TDVCDSDYAPSRRMT
Site 49S1544CDSDYAPSRRMTSVA
Site 50T1548YAPSRRMTSVATAKG
Site 51S1549APSRRMTSVATAKGY
Site 52Y1562GYTSDLNYDSEPVPP
Site 53S1564TSDLNYDSEPVPPPP
Site 54T1572EPVPPPPTPRSQYLS
Site 55S1575PPPPTPRSQYLSAEE
Site 56Y1577PPTPRSQYLSAEENY
Site 57S1579TPRSQYLSAEENYES
Site 58Y1584YLSAEENYESCPPSP
Site 59S1586SAEENYESCPPSPYT
Site 60S1590NYESCPPSPYTERSY
Site 61Y1592ESCPPSPYTERSYSH
Site 62T1593SCPPSPYTERSYSHH
Site 63S1596PSPYTERSYSHHLYP
Site 64Y1597SPYTERSYSHHLYPP
Site 65S1598PYTERSYSHHLYPPP
Site 66Y1602RSYSHHLYPPPPSPC
Site 67S1607HLYPPPPSPCTDSS_
Site 68S1612PPSPCTDSS______
Site 69S1613PSPCTDSS_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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